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Archives of Dermatological Research

Erschienen in:

01.12.2011 | Review Article

Innate immunity in the pathogenesis of psoriasis

verfasst von: Cheryl M. Sweeney, Ann-Marie Tobin, Brian Kirby

Erschienen in: Archives of Dermatological Research | Ausgabe 10/2011

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Abstract

Psoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.

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Titel: Innate immunity in the pathogenesis of psoriasis
verfasst von: Cheryl M. Sweeney
Ann-Marie Tobin
Brian Kirby
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Dermatological Research / Ausgabe 10/2011
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-011-1169-1

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Innate immunity in the pathogenesis of psoriasis

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