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01.07.2012 | Original Paper

Increased miRNA-146a and miRNA-155 expressions in oral lichen planus

verfasst von: Telma Cristina Arão, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Carolina Cavaliéri Gomes, Ricardo Santiago Gomez

Erschienen in: Archives of Dermatological Research | Ausgabe 5/2012

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Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease T helper 1 lymphocytes (Th1)-mediated. Interferon-gamma (IFN-γ) plays a central role in local immune response in this disease. MicroRNAs (miRNAs) are endogenously expressed non-coding RNAs that have important biological and pathological functions due to their potential mechanism regulating gene expression. Recently, some studies have demonstrated that miRNA-146a and miRNA-155 participate in immune response regulation, and are important in several chronic inflammatory and autoimmune diseases. The purpose of the present study was to investigate the expression of the miRNA-146a and miRNA-155 in 31 OLP lesions compared to normal oral mucosa and blood samples. Quantitative real-time polymerase chain reaction was used to analyze miRNA expressions. Our results showed increased expression of miRNA-146a and miRNA-155 in OLP lesions. In conclusion, these data highlight the possibility of miRNA-146a and miRNA-155 involvement in the regulation of the immune response in OLP.

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Titel: Increased miRNA-146a and miRNA-155 expressions in oral lichen planus
verfasst von: Telma Cristina Arão
André Luiz Sena Guimarães
Alfredo Maurício Batista de Paula
Carolina Cavaliéri Gomes
Ricardo Santiago Gomez
Publikationsdatum: 01.07.2012
Verlag: Springer-Verlag
Erschienen in: Archives of Dermatological Research / Ausgabe 5/2012
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-011-1197-x

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Increased miRNA-146a and miRNA-155 expressions in oral lichen planus

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