nach oben

Archives of Gynecology and Obstetrics

Erschienen in:

01.12.2004 | Original Article

Short-term calcium supplementation has no effect on biochemical markers of bone remodeling in early postmenopausal women

verfasst von: U. Ulrich, P. B. Miller, D. R. Eyre, C. H. Chesnut III, C. Bodenschatz, H. Schlebusch, M. R. Soules

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2004

Einloggen, um Zugang zu erhalten

Abstract

Introduction

This study was designed to assess changes in biochemical markers of bone remodeling in early postmenopausal women receiving calcium supplementation.

Materials and methods

In a randomized cross-over study of eighteen weeks duration, the effect of a 6-week calcium supplementation (1000 mg calcium carbonate) on biochemical markers of bone resorption (collagen type I cross-linked C- and N-telopeptides) and bone formation (osteocalcin, total and bone-specific alkaline phosphatase), and total serum calcium was assessed in 27 early postmenopausal women.

Results

While total serum calcium levels increased significantly due to calcium supplementation (p<0.05), biochemical markers of both bone resorption and formation remained virtually unchanged.

Conclusion

In contrast to other investigations, there was no significant short-term effect of calcium supplementation on biochemical markers of either bone resorption or formation.

Akesson K, Lau KH, Johnston P, Imperio E, Baylink DJ (1998) Effects of short-term calcium depletion and repletion on biochemical markers of bone turnover in young adult women. J Clin Endocrinol Metab 83:1921–1927PubMed

Aloia JF, Vaswani A, Yeh JK, Russo L (1996) Differential effects of dietary calcium augmentation and hormone replacement therapy on bone turnover and serum levels of calcitrophic hormones. Osteoporos Int 6:55–62PubMed

Baker V, Ulrich U (1999) Estrogen replacement and alternatives for the prevention and treatment of osteoporosis. Curr Probl Obstet Gynecol Fertil 22:73–120

Blumsohn A, Herrington K, Hannon RA, Shao P, Eyre DR, Eastell R (1994) The effect of calcium supplementation on the circadian rhythm of bone resorption. J Clin Endocrinol Metabol 79:730–735

Chesnut CH III, Bell NH, Clark GS, Drinkwater BL, English SC, Notelovitz M, Rosen C, Cain DF, Flessland KA, Mallinak NJ (1997) Hormone replacement therapy in postmenopausal women: N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med 102:29–37CrossRefPubMed

Christiansen C (1994) The different routes of administration and the effect of hormone replacement therapy on osteoporosis. Fertil Steril 62 [Suppl 6]:152–156

Compston JE (1995) The role of vitamin D and calcium supplementation in the prevention of osteoporotic fractures in the elderly. Clin Endocrinol (Oxf) 43:393–405

Elders PJM, Netelenbos JC, Lips P, van Ginkel F, Khoe E, Leeuwenkamp OR, Hackeng WHL, van der Stelt PF (1991) Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 55 years of age. J Clin Endocrinol Metab 73:533–540PubMed

Ettinger B (1992) Role of calcium in preserving the skeletal health of aging women. South Med J 85 [Suppl 2]:22–30

10.

Ettinger B, Genant HK, Cann CE (1987) Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Ann Int Med 106:40–45PubMed

11.

Eyre DR (1997) Bone biomarkers as tools in osteoporosis management. Spine 22:17S–24SCrossRefPubMed

12.

Gonnelli S, Cepollaro C, Camporeale A, Nardi P, Rossi S, Gennari C (1995) Acute biochemical variations induced by two different calcium salts in healthy perimenopausal women. Calcif Tissue Int 57:175–177PubMed

13.

Kanis JA, Melton LJ III, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137–1141PubMed

14.

Kulak CAM, Belezikian JP (1998) Osteoporosis: preventive strategies. Int J Fertil 43:56–64

15.

Lloyd T, Andon MB, Rollings N, Martel JK, Landis JR, Demers LM, Eggli DF, Kieselhorst K, Kulin H (1993) Calcium supplementation and bone mineral density in adolescent girls. JAMA 270:841–844CrossRefPubMed

16.

McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL (1996) Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption. J Clin Endocrinol Metab 81:1699–1703

17.

Nicar MJ, Pak CYC (1985) Calcium bioavailability from calcium carbonate and calcium citrate. J Clin Endocrinol Metab 61:391–393PubMed

18.

Nilas L, Christiansen C, Rodbro P (1984) Calcium supplementation and postmenopausal bone loss. Br Med J 289:1103–1106

19.

Notelovitz M (1993) Osteoporosis: screening, prevention, and management. Fertil Steril 59:707–725PubMed

20.

Prestwood KM, Thompson DL, Kenny AM, Seibel MJ, Pilbeam CC, Raisz LG (1999) Low dosage estrogen and calcium have an additive effect on bone resorption in older women. J Clin Endocrinol Metab 84:179–183PubMed

21.

Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ (1995) Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial. Am J Med 98:331–335CrossRefPubMed

22.

Riis B, Thomsen K, Christiansen C (1987) Does calcium supplementation prevent postmenopausal bone loss? N Engl J Med 316:173–177PubMed

23.

Rosen CJ, Chesnut CH III, Mallinak NJ (1997) The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation. J Clin Endocrinol Metab 82:1904–1910PubMed

24.

Senn S (1993) Cross-over trials in clinical research. Wiley, New York

25.

Steiniche T, Hasling C, Charles P, Eriksen EF, Mosekilde L, Melsen F (1989) A randomized study on the effects of estrogen/gestagen or high calcium on trabecular bone remodeling in postmenopausal osteoporosis. Bone 10:313–320PubMed

26.

Takahashi M, Kushida K, Hoshino H, Ohishi T, Inoue T (1999) Biochemical markers of bone turnover do not decline after menopause in healthy women. Br J Obstet Gynaecol 106:427–431PubMed

27.

Tukey JW (1977) Data analysis. Addison-Wesley, Reading, MA

28.

Writing Group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the women’s health initiative randomized controlled trial. JAMA 288:321–333PubMed

Titel: Short-term calcium supplementation has no effect on biochemical markers of bone remodeling in early postmenopausal women
verfasst von: U. Ulrich
P. B. Miller
D. R. Eyre
C. H. Chesnut III
C. Bodenschatz
H. Schlebusch
M. R. Soules
Publikationsdatum: 01.12.2004
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2004
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-003-0562-1

Neu im Fachgebiet Gynäkologie und Geburtshilfe

17.04.2024 | Postoperative nausea and vomiting | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Short-term calcium supplementation has no effect on biochemical markers of bone remodeling in early postmenopausal women

Abstract

Introduction

Materials and methods

Results

Conclusion

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Gynäkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Introduction

Materials and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2004

Seventeen-year review of hysterectomy procedures in a university clinic in İstanbul (1985–2001)

Results of controlled ovarian stimulation for ART in poor responders according to the short protocol using different gonadotrophins combinations

Anaplastic (pleomorphic) subtype embryonal rhabdomyosarcoma of the cervix

Asymptomatic vasculitis of the uterine cervix in presence of cervical intraepithelial neoplasia grade III

Retroperitoneal mucinous cystadenoma

Synchronous cancer and metastatic melanoma of the breasts

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hochrisiko-Eingriffe für postoperative Übelkeit

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Gynäkologie