nach oben

Archives of Gynecology and Obstetrics

Erschienen in:

01.09.2011 | Reproductive Medicine

Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome

verfasst von: Xiaobo Shi, Lingyan Zhang, Shuxin Fu, Na Li

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2011

Einloggen, um Zugang zu erhalten

Abstract

Objective

To investigate psychological distress, serum levels of monoamine neurotransmitters and their metabolites, as well as their correlation with polycystic ovarian syndrome (PCOS).

Methods

Thirty infertility patients with PCOS were assigned as the experimental group and 30 infertility patients without PCOS were assigned as the control group. Psychological distress was self-evaluated in all patients with Symptom Checklist 90 (SCL-90). Serum concentrations of norepinephrine (NE) and its metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) and its metabolites homovanillic acid (HVA) and dihydroxy-phenyl acetic acid (DOPAC) were measured by high-performance liquid chromatography.

Results

The anxious and depressive subscales of SCL-90 were significantly higher in infertility patients with PCOS than those without PCOS (p < 0.05). The serum concentrations of 5-HT, 5-HIAA and HVA were significantly lower in infertility patients with PCOS than those without PCOS (p < 0.05). Importantly, the phobia subscale scores of SCL-90 positively correlated with serum MHPG level (p < 0.05), while the hostility subscale’s scores negatively correlated with serum DOPAC level (p < 0.05).

Conclusion

Psychological and neurological factors play a crucial role in PCOS.

Balen A, Michelmore K (2002) What is polycystic ovary syndrome? Are national views important? Hum Reprod 17:2219–2227PubMedCrossRef

Jones GL, Balen AH, Ledger WL (2008) Health-related quality of life in PCOS and related infertility: how can we assess this? Hum Fertil (Camb) 11:173–185CrossRef

Doi SA, Towers PA, Scott CJ, Al-Shoumer KA (2005) PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adrenal axis? Eur J Obstet Gynecol Reprod Biol 118:4–16PubMedCrossRef

Teede H, Deeks A, Moran L (2010) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med 8:41PubMedCrossRef

Blank SK, Helm KD, McCartney CR, Marshall JC (2008) Polycystic ovary syndrome in adolescence. Ann N Y Acad Sci 1135:76–84PubMedCrossRef

Legro RS, Castracane VD, Kauffman RP (2004) Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Surv 59:141–154PubMedCrossRef

Murdoch AP, Dunlop W, Kendall-Taylor P, Watson MJ (1984) The acute effects of a dopamine antagonist (domperidone) on luteinising hormone, follicule stimulating hormone, prolactin and thyrotrophin secretion in polycystic ovarian syndrome: differential effect of ovulation. Clin Endocrinol (Oxf) 21:611–619CrossRef

Moro C, Pasarica M, Elkind-Hirsch K, Redman LM (2009) Aerobic exercise training improves atrial natriuretic peptide and catecholamine-mediated lipolysis in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 94:2579–2586PubMedCrossRef

Eyvazzadeh AD, Pennington KP, Pop-Busui R, Sowers M, Zubieta JK, Smith YR (2009) The role of the endogenous opioid system in polycystic ovary syndrome. Fertil Steril 92:1–12PubMedCrossRef

10.

Deeks AA, Gibson-Helm ME, Teede HJ (2010) Anxiety and depression in polycystic ovary syndrome: a comprehensive investigation. Fertil Steril 93:2421–2423PubMedCrossRef

11.

Himelein MJ, Thatcher SS (2006) Polycystic ovary syndrome and mental health: a review. Obstet Gynecol Surv 61:723–732PubMedCrossRef

12.

Elsenbruch S, Benson S, Hahn S, Tan S, Mann K, Pleger K, Kimmig R, Janssen OE (2006) Determinants of emotional distress in women with polycystic ovary syndrome. Hum Reprod 21:1092–1099PubMedCrossRef

13.

Elsenbruch S, Hahn S, Kowalsky D, Offner AH, Schedlowski M, Mann K, Janssen OE (2003) Quality of life, psychosocial well-being, and sexual satisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88:5801–5807PubMedCrossRef

14.

Deeks AA, Gibson-Helm ME, Teede HJ (2010) Anxiety and depression in polycystic ovary syndrome: a comprehensive investigation. Fertil Steril 93:2421–2423PubMedCrossRef

15.

Derogatis LR, Lipman RS, Covi L (1973) SCL-90: an outpatient psychiatric rating scale—preliminary report. Psychopharmacol Bull 9:13–28PubMed

16.

Mc Cook JG, Reame NE, Thatcher SS (2005) Health-related quality of life issues in women with polycystic ovary syndrome. J Obstet Gynecol Neonatal Nurs 34:12–20CrossRef

17.

Coffey S, Mason H (2003) The effect of polycystic ovary syndrome on health related quality of life. Gynecol Endocrinol 17:379–386PubMedCrossRef

18.

Dokras A, Clifton S, Futterweit W, Wild R (2011) Increased risk for abnormal depression scores in women with polycystic ovary syndrome: a systematic review and meta-analysis. Obstet Gynecol 117:145–152PubMedCrossRef

19.

Elsenbruch S, Hahn S, Kowalsky D et al (2003) Quality of life, psychosocial well being, and sexual satisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 88:5801–5807PubMedCrossRef

20.

Wang Y, Cao Y, Chong L et al (2005) Polycystic ovary syndrome and psychological analysis of the investigation. Anhui Med Univ (in Chinese) 40:277–279

21.

Herbison AE (1997) Noradrenergic regulation of cyclic GnRH secretion. Rev Reprod 2:1–6PubMedCrossRef

22.

Yoshino K, Takahashi K, Eda Y, Nishigaki A, Kitao M (1991) Peripheral catecholamine metabolites and free testosterone in patients with polycystic ovary syndrome. Nippon Sanka Fujinka Gakkai Zasshi 43:351–354PubMed

23.

Barontini M, García-Rudaz MC, Veldhuis JD (2001) Mechanisms of hypothalamic-pituitary-gonadal disruption in polycystic ovarian syndrome. Arch Med Res 32:544–552PubMedCrossRef

24.

Hernandez I, Parra A, Mendez I et al (2000) Hypothalamic dopaminergic tone and prolactin bioactivity in women with polycystic ovary syndrome. Arch Med Res 31:216–222PubMedCrossRef

25.

Ramirez VD, Dluzen DE (1987) Release of luteinizing hormone-releasing hormone (LHRH) and neuroactive substances in unanesthetized animals as estimated with push-pull cannulae (PPC). Biol Reprod 36:59–76PubMedCrossRef

26.

Wang J, Ouyang D, Ke J et al (2005) Neurotransmitter NA, 5-HT levels in hippocampus and content changes of GnRH in hypothalamus in female rats exposed to psychologic stress. Chinese J Gerontology (In Chinese) 25:673–674

27.

Lobo RA, Granger LR, Paul WL et al (1983) Psychological stress and increases in urinary norepinephrine metabolites, platelet serotonin, and adrenal androgens in women with polycystic ovary syndrome. Am J Obstet Gynecol 145:496–503PubMed

28.

Gill SS, Pulido OM (2001) Glutamate receptors in peripheral tissues: current knowledge, future research, and implications for toxicology. Toxicol Pathol 29:208–223PubMedCrossRef

29.

Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H (2002) GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol 213:1–47PubMedCrossRef

30.

de Groat WC (2006) Integrative control of the lower urinary tract: preclinical perspective. Br J Pharmacol 147:S25–S40PubMedCrossRef

31.

Roth BL, Chuang DM (1987) Multiple mechanisms of serotonergic signal transduction. Life Sci 41:1051–1064PubMedCrossRef

32.

Hafkenscheid A (1993) Psychometric evaluation of the symptom checklist (SCL-90) in psychiatric inpatients. Pers Individ Differ 14:751–756CrossRef

33.

Clark A, Friedman MJ (1983) Factor structure and discriminant validity of the SCL-90 in a veteran psychiatric population. J Pers Assess 47:396–404PubMedCrossRef

34.

Cyr JJ, McKenna-Foley JM, Peacock E (1985) Factor structure of the SCL-90-R: is there one? J Pers Assess 49:571–578PubMedCrossRef

35.

Grabill K, Merlo L, Duke D, Harford KL, Keeley ML, Geffken GR, Storch EA (2008) Assessment of obsessive–compulsive disorder: a review. J Anxiety Disord 22:1–17PubMedCrossRef

36.

Ganellen RJ (2007) Assessing normal and abnormal personality functioning: strengths and weaknesses of self-report, observer, and performance-based methods. J Pers Assess 89:30–40PubMedCrossRef

Titel: Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome
verfasst von: Xiaobo Shi
Lingyan Zhang
Shuxin Fu
Na Li
Publikationsdatum: 01.09.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-1947-1

Neu im Fachgebiet Gynäkologie und Geburtshilfe

23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Co-involvement of psychological and neurological abnormalities in infertility with polycystic ovarian syndrome

Abstract

Objective

Methods

Results

Conclusion

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2011

Antioxidant prophylaxis for cellular injury in ovarian surface epithelium resulting from CO2 pneumoperitoneum in a laparoscopic rat model

Turkish obstetricians’ personal preference for mode of delivery and attitude toward cesarean delivery on maternal request

Multiple laparotomic myomectomy during pregnancy: a case report

Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug

Iron status parameters in preeclamptic women

Recurrent pancreatitis induced by hyperparathyroidism in pregnancy

Neu im Fachgebiet Gynäkologie und Geburtshilfe

ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

Update Gynäkologie