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Archives of Gynecology and Obstetrics

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01.12.2011 | General Gynecology

Endometriosis: the consequence of uterine denervation–reinnervation

verfasst von: Martin J. Quinn

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2011

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Abstract

Difficult intrapartum episodes and persistent straining during defecation cause injuries to uterine nerves and uterosacral ligaments. Injuries to uterine nerves (denervation) result in loss of fundocervical polarity, uterotubal dysmotility and retrograde menstruation. Ectopic endometrium, delivered by retrograde menstruation, adheres to injuries to uterosacral ligaments and peritoneal surfaces. Difficult vaginal deliveries result in laparoscopic appearances of asymmetry of uterosacral ligaments with, or without, ectopic endometrium. Straining during defaecation causes the “classic” appearances of nulliparous endometriosis including hypertrophy of the uterosacral ligaments often with large volumes of ectopic endometrium. Laparoscopic appearances depend on the site, nature, extent, and timing of tissue injury, as well as the presence of available endometrium. Tissue repair, including reinnervation in the uterine isthmus, cervix, vagina and uterosacral ligaments, contributes to chronic pelvic pain, dysmenorrhea, dyspareunia and subfertility some time after the primary injuries.

Slocumb JC (1990) Chronic somatic, myofascial, and neurogenic abdominal pelvic pain. Clin Obstet Gynecol 33(1):145–153PubMedCrossRef

Quinn M (2009) Endometriosis: an elusive epiphenomenon. J Obstet Gynaecol 29(7):590–593PubMedCrossRef

Stoll G, Muller HW (1999) Nerve injury, axonal regeneration and neuronal regeneration: basic insights. Brain Pathol 9(2):313–325PubMedCrossRef

Cervero F (2000) Visceral hyperalgesia-revisited. Lancet 356:1127–1128PubMedCrossRef

Sampson JA (1921) Perforating hemorrhagic (chocolate) cysts of the ovary. Their importance and specially their relation to pelvic adenomas of endometriotic type (“adenomyoma” of the uterus, rectovaginal septum, sigmoid etc.). Arch Surg 3:245–322

Sampson JA (1924) Benign and malignant endometrial implants in the peritoneal cavity and their relation to certain ovarian tumors. Surg Gynecol Obstet 38:287–311

Sampson JA (1927) Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 14:422–446

Lee R (1948) On the nervous ganglia of the uterus, and an appendix to a paper on the nervous ganglia of the uterus, with a further account of the nervous structures of that organ. Phil Trans 1841:i269–i275

Spackman R, Wrigley B, Roberts A, Quinn M (2007) The inferior hypogastric plexus: a different view. J Obstet Gynaecol 27(2):130–133PubMedCrossRef

10.

Campbell RM (1950) The anatomy and histology of the sacrouterine ligaments. Am J Obstet Gynecol 59:1–12PubMed

11.

Krantz KE (1959) Innervation of the human uterus. Ann NY Acad Sci 75:770–784PubMedCrossRef

12.

Tokushige N, Markham R, Russell P, Fraser IS (2006) High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis. Hum Reprod 21:782–787PubMedCrossRef

13.

Tokushige N, Markham R, Russell P, Fraser IS (2006) Nerve fibres in peritoneal endometriosis. Hum Reprod 21:3001–3007PubMedCrossRef

14.

Wang GY, Tokushige N, Markham R, Fraser IS (2009) Rich innervation of deep infiltrating endometriosis. Hum Reprod 24(4):827–834PubMedCrossRef

15.

Quinn MJ, Kirk N (2002) Differences in uterine innervation at hysterectomy. Am J Obstet Gynecol 187(6):1515–1519PubMedCrossRef

16.

Atwal GSS, Duplessis D, Armstrong GR, Slade RJ, Quinn MJ (2005) Uterine innervation after hysterectomy for chronic pelvic pain with, or without, endometriosis. Am J Obstet Gynecol 193:1658–1663CrossRef

17.

Kelm Junior AR, Lancellotti CL, Donadio N, Auge AP, Lima SM, Aoki T, Ribeiro PA (2008) Nerve fibers in uterosacral ligaments of women with deep infiltrating endometriosis. J Reprod Immunol 79(1):93–99PubMedCrossRef

18.

Zhang X, Lu B, Huang X, Xu H, Zhou C, Lin J (2009) Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids. Fertil Steril 92(5):1799–1801PubMedCrossRef

19.

Allen WM, Masters WH (1955) Traumatic laceration of uterine support. Am J Obstet Gynecol 70:500–513PubMed

20.

Allen WM (1971) Chronic pelvic congestion and pelvic pain. Am J Obstet Gynecol 109:198–202PubMed

21.

Professor Sir Dugald Baird (1957) Preface to the 6th edition, “Combined Textbook of Obstetrics and Gynaecology”, Livingstone

22.

Snooks SJ, Swash M, Mathers SE, Henry MM (1990) Effect of vaginal delivery on the pelvic floor: a 5-year follow-up. Br J Surg 77(12):1358–1360PubMedCrossRef

23.

Quinn M (2007) Levator defects and chronic pelvic pain. J Obstet Gynaecol 57(3):357–362

24.

Quinn M (2007) Perivascular nerve fibre proliferation; the consequence of prolonged straining. J Obstet Gynaecol 27(2):185–188PubMedCrossRef

25.

Golding J (2009) Measuring outcomes in a longitudinal birth cohort. Paediatr Perinat Epidemiol 23(Suppl 1):185–200PubMedCrossRef

26.

Heaton KW, Cripps HA (1993) Straining at stool and laxative taking in an English population. Dig Dis Sci 38:1004–1008PubMedCrossRef

27.

Probert CS, Emmett PM, Cripps HA, Heaton KW (1994) Evidence for the ambiguity of the term constipation: the role of irritable bowel syndrome. Gut 35(10):1455–1458PubMedCrossRef

28.

Zhang G, Dmitrieva N, Liu Y, McGinty KA, Berkley KJ (2008) Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat. Am J Physiol Regul Integr Comp Physiol 294(1):R162–R171PubMedCrossRef

29.

Janig W (2006) Integrative action of the autonomic nervous system: neurobiology of homeostasis. Cambridge University Press, CambridgeCrossRef

30.

Westrom LV, Willen R (1998) Vestibular nerve fiber proliferation in vulvar vestibulitis syndrome. Obstet Gynecol 91:572–576PubMedCrossRef

31.

Schofield EC, Clausen JA, Burcher E, Moore KH (2005) GAP-Immunoreactivity of subepithelial and detrusor muscle nerve fibres in patients with refractory idiopathic detrusor overactivity. Neurourol Urodynam 24:325–333CrossRef

32.

Chan CLH, Facer P, Davis JB, Smith GD, Egerton J, Bountra C, Williams NS, Anand P (2003) Sensory fibre expressing capsaicin receptor TRPV-1 in patients with rectal hypersensitivity and faecal urgency. Lancet 361:385–391PubMedCrossRef

33.

Zondervan KT, Yudkin PL, Vessey MP, Dawes MG, Barlow DH, Kennedy SH (1999) Prevalence and incidence of chronic pelvic pain in primary care: evidence from a national general practice database. Brit J Obstet Gynaecol 106:1149–1155CrossRef

34.

Zondervan KT, Yudkin PL, Vessey MP, Dawes MG, Barlow DH, Kennedy SH (1999) Patterns of diagnosis and referral in women consulting for chronic pelvic pain in UK primary care. Brit J Obstet Gynaecol 106:1156–1161CrossRef

35.

Namnoum AB, Hickman TN, Goodman SB (1995) Incidence of symptom recurrence after hysterectomy for endometriosis. Fertil Steril 64:898–902PubMed

36.

MacDonald SR, Klock SC, Milad MP (1999) Long-term outcome of nonconservative surgery (hysterectomy) for endometriosis-associated pain in women <30 years old. Am J Obstet Gynecol 180(6):1360–1363PubMedCrossRef

37.

Leyendecker G, Wildt L, Mall G (2009) The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch Gynecol Obstet 280(4):529–538PubMedCrossRef

38.

Kissler S, Hamscho N, Zangos S, Wiegratz I, Schlichter S, Menzel, Doebert N, Gruenwald F, Vogl TJ, Gaetje R, Rody A, Siebzehnruebl E, Kunz G, Leyendecker G, Kaufmann M (2006) Uterotubal transport disorder in adenomyosis and endometriosis—a cause for infertility. Brit J Obstet Gynaecol. 113(8):902–908CrossRef

39.

Stephansson O, Kieler H, Granath F, Falconer H (2009) Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome. Hum Reprod 24(9):2341–2347PubMedCrossRef

40.

Huang JQ, Bunker Lathi R, Lemyre M, Rodriguez HE, Nezhat CH, Nezhat C (2010) Coexistence of endometriosis in women with symptomatic leiomyomas. Fertil Steril 94(2):720–723PubMedCrossRef

41.

Quinn M (2007) Uterine innervation in adenomyosis. J Obstet Gynaecol 27(3):287–291PubMedCrossRef

42.

Quinn M (2007) Uterine innervation in fibroids. J Obstet Gynecol 27(5):489–492CrossRef

43.

Straub RH (2007) Autoimmune disease and innervation. Brain Behav Immun 21(5):528–534PubMedCrossRef

44.

Gemmill JA, Stratton P, Cleary SD, Ballweg ML, Sinaii N (2010) Cancers, infections, and endocrine diseases in women with endometriosis. Fertil Steril 94(5):1627–1631PubMedCrossRef

Titel: Endometriosis: the consequence of uterine denervation–reinnervation
verfasst von: Martin J. Quinn
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 6/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-2063-y

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Endometriosis: the consequence of uterine denervation–reinnervation

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