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Archives of Gynecology and Obstetrics

Erschienen in:

01.03.2014 | Gynecologic Oncology

Supplemental screening ultrasound increases cancer detection yield in BRCA1 and BRCA2 mutation carriers

verfasst von: Kristin Bosse, Monika Graeser, Axel Goßmann, Matthias Hackenbroch, Rita K. Schmutzler, Kerstin Rhiem

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2014

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Abstract

Introduction

This study aimed at evaluating the efficacy of ultrasound for the early detection of breast cancers in BRCA1/2 mutation carriers.

Methods

Between 01/1997 and 10/2008 221 BRCA1/2 mutation carriers participated in a breast cancer screening program which included semi-annual ultrasound in combination with annual mammography and magnetic resonance imaging (MRI). Women underwent on average (median) five semi-annual screening rounds with a range of one to 22 appointments, totaling 1,855 rounds of screening. All three imaging modalities were coded according to the American College of Radiology (BI-RADS classification).

Results

In total, we detected 27 BRCA-associated breast cancers in 25 patients. The sensitivity was 77 % for ultrasound, 27 % for mammography, and 100 % for MRI. Three tumors were detected directly as a result of only the semi-annual ultrasound screen.

Conclusions

Due to the specific tumor morphology and the considerably elevated tumor doubling time, mutation carriers benefit from the addition of semi-annual ultrasound screening as a sensitive and cost-effective method.

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Titel: Supplemental screening ultrasound increases cancer detection yield in BRCA1 and BRCA2 mutation carriers
verfasst von: Kristin Bosse
Monika Graeser
Axel Goßmann
Matthias Hackenbroch
Rita K. Schmutzler
Kerstin Rhiem
Publikationsdatum: 01.03.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2014
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-013-3022-6

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Supplemental screening ultrasound increases cancer detection yield in BRCA1 and BRCA2 mutation carriers

Abstract

Introduction

Methods

Results

Conclusions

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