Erschienen in:
01.12.2017 | Maternal-Fetal Medicine
Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development
verfasst von:
Margarita L. Martinez-Fierro, Idalia Garza-Veloz, Cristina Gutierrez-Arteaga, Ivan Delgado-Enciso, Olga Y. Barbosa-Cisneros, Virginia Flores-Morales, Gloria P. Hernandez-Delgadillo, Maria R. Rocha-Pizaña, Iram P. Rodriguez-Sanchez, Jose I. Badillo-Almaraz, Jose M. Ortiz-Rodriguez, Rodrigo Castañeda-Miranda, Luis O. Solis-Sanchez, Yolanda Ortiz-Castro
Erschienen in:
Archives of Gynecology and Obstetrics
|
Ausgabe 2/2018
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Abstract
Purpose
To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development.
Methods
Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls (n = 18) using TaqMan low density array plates.
Results
A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, were differentially expressed between groups (P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE (P = 0.035) and WWD-Severe-PE (P = 0.007).
Conclusions
Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further.