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Erschienen in: Archives of Gynecology and Obstetrics 2/2018

01.12.2017 | Maternal-Fetal Medicine

Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development

verfasst von: Margarita L. Martinez-Fierro, Idalia Garza-Veloz, Cristina Gutierrez-Arteaga, Ivan Delgado-Enciso, Olga Y. Barbosa-Cisneros, Virginia Flores-Morales, Gloria P. Hernandez-Delgadillo, Maria R. Rocha-Pizaña, Iram P. Rodriguez-Sanchez, Jose I. Badillo-Almaraz, Jose M. Ortiz-Rodriguez, Rodrigo Castañeda-Miranda, Luis O. Solis-Sanchez, Yolanda Ortiz-Castro

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2018

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Abstract

Purpose

To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development.

Methods

Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls (n = 18) using TaqMan low density array plates.

Results

A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, were differentially expressed between groups (P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE (P = 0.035) and WWD-Severe-PE (P = 0.007).

Conclusions

Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further.
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Metadaten
Titel
Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development
verfasst von
Margarita L. Martinez-Fierro
Idalia Garza-Veloz
Cristina Gutierrez-Arteaga
Ivan Delgado-Enciso
Olga Y. Barbosa-Cisneros
Virginia Flores-Morales
Gloria P. Hernandez-Delgadillo
Maria R. Rocha-Pizaña
Iram P. Rodriguez-Sanchez
Jose I. Badillo-Almaraz
Jose M. Ortiz-Rodriguez
Rodrigo Castañeda-Miranda
Luis O. Solis-Sanchez
Yolanda Ortiz-Castro
Publikationsdatum
01.12.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 2/2018
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-017-4611-6

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