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European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.05.2004 | Rhinology

Expression of human β-defensin 2 in human nasal mucosa

verfasst von: Po-Hsu Chen, Sheen-Yie Fang

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2004

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Abstract

Human β-defensin (HBD)-2, an antimicrobial peptide, has been discovered to be produced by a number of epithelial cells. It is identified as a key element in the innate host defense mechanism. Because little is known about the expression of HBD-2 in the human sinonasal tract, we conducted this study to investigate the expression of the HBD-2 mRNA gene by the reverse transcription polymerase chain reaction (RT-PCR) and localization of HBD-2 peptide by immunohistochemistry in human nasal inferior turbinates and nasal polyps. RT-PCR showed significantly higher expression of HBD-2 mRNA in nasal polyps than in inferior turbinates. Using immunohistochemistry, HBD-2 peptide was predominately localized in surface epithelial cells. Thus, it is feasible that HBD-2 is expressed in nasal mucosa and is upregulated in a condition of chronic inflammation.

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Titel: Expression of human β-defensin 2 in human nasal mucosa
verfasst von: Po-Hsu Chen
Sheen-Yie Fang
Publikationsdatum: 01.05.2004
Verlag: Springer-Verlag
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2004
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-003-0682-z

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Expression of human β-defensin 2 in human nasal mucosa

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