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European Archives of Oto-Rhino-Laryngology

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01.06.2009 | Review Article

Molecular pathways and genetic factors in the pathogenesis of laryngopharyngeal reflux

verfasst von: Alexios S. Vardouniotis, Alexander D. Karatzanis, Eleni Tzortzaki, Elias Athanasakis, Katerina D. Samara, Georgios Chalkiadakis, Nikolaos Siafakas, George A. Velegrakis

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 6/2009

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Abstract

The prevalence of laryngopharyngeal reflux (LPR) has been constantly rising in the western world and affects today an alarmingly high percentage of the general population. Even though LPR and gastroesophageal reflux disease (GERD) are both the product of gastroesophageal reflux and seem to be sibling disorders, they constitute largely different pathological entities. While GERD has been for a long time identified as a source of esophageal disease, LPR has only recently been associated with head and neck disorders. Despite the high incidence of LPR and its great impact on patients’ quality of life, little is known regarding its pathogenesis. On the other hand, studying the molecular and genetic basis of a disease is of fundamental importance in medicine as it offers better insight into the pathogenesis and opens new, disease-specific therapeutic trends. The aim of this study is to enlighten any known or suspected molecular mechanisms that contribute to the pathogenesis of LPR, and to suggest new trends for future research.

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Titel: Molecular pathways and genetic factors in the pathogenesis of laryngopharyngeal reflux
verfasst von: Alexios S. Vardouniotis
Alexander D. Karatzanis
Eleni Tzortzaki
Elias Athanasakis
Katerina D. Samara
Georgios Chalkiadakis
Nikolaos Siafakas
George A. Velegrakis
Publikationsdatum: 01.06.2009
Verlag: Springer-Verlag
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 6/2009
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-009-0966-z

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