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Erschienen in: European Archives of Oto-Rhino-Laryngology 4/2012

01.04.2012 | Head and Neck

An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery

verfasst von: Raghav C. Dwivedi, Edward J. Chisholm, Afroze S. Khan, Nicholas J. Harris, Shree A. Bhide, Suzanne St.Rose, Cyrus J. Kerawala, Peter M. Clarke, Christopher M. Nutting, Peter H. Rhys-Evans, Kevin J. Harrington, Rehan Kazi

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 4/2012

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Abstract

There are insufficient data on swallowing and the consequences of its dysfunction in patients with cancers of the oral cavity (OC) and oropharynx (OP) that are treated with primary surgery. The study attempts to explore the effect of important clinico-demographic variables on post-treatment swallowing and related quality of life (QOL) in post-surgical OC and OP cancer patients. Sixty-two consecutive OC and OP cancer patients completed the MD Anderson Dysphagia Inventory (MDADI) questionnaire. Mean scores were computed. Comparison of scores based on mean ranks were performed using Mann–Whitney U test or Kruskal–Wallis test. Level of significance was set at P ≤ 0.02. Adjustments were made for multiple comparisons. Significantly worse mean (SD) QOL scores were observed in late T-stage (T3/T4) versus early T-stage (T1/T2) patients for global domain, physical domain, functional domain and emotional domains [44.4 (21.9) vs. 78.7 (22.7) (P < 0.001); 50.0 (9.4) vs. 75.9 (16.3), (P < 0.0001); 57.8 (20.6) vs. 84.1 (16.7), (P < 0.001) and 55.2 (18.0) vs. 78.5 (16.3), (P < 0.001)], respectively. Patients undergoing reconstruction versus without reconstruction had worse QOL scores; 58.8 (26.9) versus 79.5 (22.8), (P < 0.01); 61.2 (15.1) versus 76.4 (17.5), (P = 0.002); 65.4 (20.5) versus 86.3 (15.9), (P < 0.0001) and 63.3 (18.8) versus 79.8 (16.3), (P < 0.01), respectively, for global, physical, functional and emotional domains. Advanced T-stage, reconstruction, younger age and base of tongue tumours have a negative impact on post-treatment swallow function and related QOL in these patients.
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Metadaten
Titel
An exploratory study of the influence of clinico-demographic variables on swallowing and swallowing-related quality of life in a cohort of oral and oropharyngeal cancer patients treated with primary surgery
verfasst von
Raghav C. Dwivedi
Edward J. Chisholm
Afroze S. Khan
Nicholas J. Harris
Shree A. Bhide
Suzanne St.Rose
Cyrus J. Kerawala
Peter M. Clarke
Christopher M. Nutting
Peter H. Rhys-Evans
Kevin J. Harrington
Rehan Kazi
Publikationsdatum
01.04.2012
Verlag
Springer-Verlag
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 4/2012
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-011-1756-y

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