nach oben

European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.07.2014 | Head and Neck

New diagnostic markers in salivary gland tumors

verfasst von: Sven Schneider, Philipp Kloimstein, Johannes Pammer, Werner Brannath, Matthaeus Ch. Grasl, Boban M. Erovic

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 7/2014

Einloggen, um Zugang zu erhalten

Abstract

Parotid gland tumors are a rare and heterogeneous entity. Molecular markers are sparse. The aim of the study was to identify new diagnostic markers in benign and malignant salivary tumors. A tissue microarray was constructed with 158 tumor samples. Expression of 21 tumor antigens involved in tumor cell survival and known for prognostic potential was assessed immunohistochemically in all parotid gland samples. CEA, Cox-1, Cox-2, Sigma, beta-Catenin, WISP-1 and PDGF-beta were differently regulated in benign and malignant parotid tumors. Subsequently, these seven proteins entered the step-wise logistic regression analysis. As a second step, we defined a score for differentiating benign versus malignant parotid lesions: 4*CEA+15*Cox-1+4*Cox-2+4*Sigma+3*PDGF-beta+10*beta-Catenin+14*Wisp1. Sensitivity and specificity of 94 and 83 % were reached. Besides routine hematoxylin and eosin staining, definition of new diagnostic markers and subsequently a new diagnostic score are an attempt to create an additional tool for the diagnosis of parotid gland tumors.

Seifert G, Sobin LH (1992) The World Health Organization’s histological classification of salivary gland tumors. A commentary on the second edition. Cancer 70:379–385PubMedCrossRef

Speight PM, Barrett AW (2002) Salivary gland tumours. Oral Dis 8:229–240PubMedCrossRef

Surveillance, Epidemiology and End Results (SEER) Program: http://www.seer.cancer.gov

Chhieng DC, Paulino AF (2002) Basaloid tumors of the salivary glands. Ann Diagn Pathol 6:364–372PubMedCrossRef

Klijanienko J, el-Naggar AK, Vielh P (1999) Comparative cytologic and histologic study of fifteen salivary basal-cell tumors: differential diagnostic considerations. Diagn Cytopathol 21:30–34PubMedCrossRef

Woo VL, Bhuiya T, Kelsch R (2006) Assessment of CD43 expression in adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, and monomorphic adenomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:495–500PubMedCrossRef

Aoki T, Tsukinoki K, Karakida K, Ota Y, Otsuru M, Kaneko A (2004) Expression of cyclooxygenase-2, Bcl-2 and Ki-67 in pleomorphic adenoma with special reference to tumor proliferation and apoptosis. Oral Oncol 40:954–959PubMedCrossRef

Davies SR, Watkins G, Mansel RE, Jiang WG (2007) Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer. Ann Surg Oncol 14:1909–1918PubMedCrossRef

Erovic BM, Pelzmann M, Turhani D et al (2003) Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma. Acta Otolaryngol 123:950–953PubMedCrossRef

10.

Heldin CH, Westermark B (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 79:1283–1316PubMed

11.

Luukkaa H, Klemi P, Leivo I, Vahlberg T, Grenman R (2006) Prognostic significance of Ki-67 and p53 as tumor markers in salivary gland malignancies in Finland: an evaluation of 212 cases. Acta Oncol 45:669–675PubMedCrossRef

12.

Patel RS, Hughes CW, Fredericks S et al (2007) Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland. Histopathology 51:21–25PubMedCrossRef

13.

Pennica D, Swanson TA, Welsh JW et al (1998) WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci USA 95:14717–14722PubMedCentralPubMedCrossRef

14.

Polakis P (1999) The oncogenic activation of beta-catenin. Curr Opin Genet Dev 9:15–21PubMedCrossRef

15.

van de Wetering M, Sancho E, Verweij C et al (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111:241–250PubMedCrossRef

16.

To VS, Chan JY, Tsang RK, Wei WI (2012) Review of salivary gland neoplasms. ISRN Otolaryngol 270:681–688

17.

Moeller K, Esser D, Boeger D et al (2013) Parotidectomy and submandibulectomy for benign diseases in Thuingia, Germany: a population-based study on epidemiology and outcome. Eur Arch Otorhinolaryngol 270:1149–1155PubMedCrossRef

18.

Park MY, Hastie T (2007) L1-regularized path algorithm for generalized linear models. J Roy Stat Soc B Met 69:659–677CrossRef

19.

Goeman JJ (2010) L1 penalized estimation in the Cox proportional hazards model. Biom J 52:70–84PubMed

20.

Cheuk W, Chan JK (2007) Advances in salivary gland pathology. Histopathology 51:1–20PubMedCrossRef

21.

Nagao T, Sugano I, Ishida Y et al (1998) Basal cell adenocarcinoma of the salivary glands: comparison with basal cell adenoma through assessment of cell proliferation, apoptosis, and expression of p53 and bcl-2. Cancer 82:439–447PubMedCrossRef

22.

Kononen J, Bubendorf L, Kallioniemi A et al (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4:844–847PubMedCrossRef

23.

Torhorst J, Bucher C, Kononen J et al (2001) Tissue microarrays for rapid linking of molecular changes to clinical endpoints. Am J Pathol 159:2249–2256PubMedCentralPubMedCrossRef

24.

Peifer M, McCrea PD, Green KJ, Wieschaus E, Gumbiner BM (1992) The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol 118:681–691PubMedCrossRef

25.

Calvisi DF, Conner EA, Ladu S, Lemmer ER, Factor VM, Thorgeirsson SS (2005) Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. J Hepatol 42:842–849PubMedCrossRef

26.

Polakis P (2007) The many ways of Wnt in cancer. Curr Opin Genet Dev 17:45–51PubMedCrossRef

27.

Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (2001) beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105:533–545PubMedCrossRef

28.

Latinkic BV, Mo FE, Greenspan JA et al (2001) Promoter function of the angiogenic inducer Cyr61gene in transgenic mice: tissue specificity, inducibility during wound healing, and role of the serum response element. Endocrinology 142:2549–2557PubMed

29.

Kouzu Y, Uzawa K, Kato M et al (2006) WISP-2 expression in human salivary gland tumors. Int J Mol Med 17:567–573PubMed

30.

Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP (2001) Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res 61:8917–8923PubMed

31.

da Cruz Perez DE, Pires FR, Alves FA, Almeida OP, Kowalski LP (2004) Salivary gland tumors in children and adolescents: a clinicopathologic and immunohistochemical study of fifty-three cases. Int J Paediatr Otorhinolaryngol 68:895–902CrossRef

32.

Alfaro M, Carrozza M (1990) Immunohistochemical localization of carcinoembryonic antigen (CEA) in salivary gland tumors. Oral Surg Oral Med Oral Pathol 69:479–482PubMedCrossRef

33.

Magnusson PU, Looman C, Ahgren A, Wu Y, Claesson-Welsh L, Heuchel RL (2007) Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro. Arterioscler Thromb Vasc Biol 27:2142–2149PubMedCrossRef

34.

Tallquist M, Kazlauskas A (2004) PDGF signaling in cells and mice. Cytokine Growth Factor Rev 15:205–213PubMedCrossRef

35.

Yu J, Moon A, Kim HR (2001) Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration. Biochem Biophys Res Commun 282:697–700PubMedCrossRef

36.

Fruttiger M, Calver AR, Kruger WH et al (1996) PDGF mediates a neuron-astrocyte interaction in the developing retina. Neuron 17:1117–1131PubMedCrossRef

37.

Zymek P, Bujak M, Chatila K et al (2006) The role of platelet-derived growth factor signaling in healing myocardial infarcts. J Am Coll Cardiol 48:2315–2323PubMedCrossRef

38.

Harris KE, Schnittke N, Beckendorf SK (2007) Two ligands signal through the Drosophila PDGF/VEGF receptor to ensure proper salivary gland positioning. Mech Dev 124:441–448PubMedCentralPubMedCrossRef

39.

Hayes A, Scase T, Miller J, Murphy S, Sparkes A, Adams V (2006) COX-1 and COX-2 expression in feline oral squamous cell carcinoma. J Comp Pathol 135:93–99PubMedCrossRef

40.

Rossiello L, Ruocco E, Signoriello G et al (2007) Evidence of COX-1 and COX-2 expression in Kaposi’s sarcoma tissues. Eur J Cancer 43:1232–1241PubMedCrossRef

41.

Erovic BM, Woegerbauer M, Pammer J, Selzer E, Grasl M, Thurnher D (2008) Strong evidence for up-regulation of cyclooxygenase-1 in head and neck cancer. Eur J Clin Invest 38:61–66PubMedCrossRef

42.

Akrish S, Peled M, Ben-Izhak O, Nagler RM (2009) Malignant salivary gland tumors and cyclo-oxygenase-2: a histopathological and immunohistochemical analysis with implications on histogenesis. Oral Oncol 45:1044–1050PubMedCrossRef

Titel: New diagnostic markers in salivary gland tumors
verfasst von: Sven Schneider
Philipp Kloimstein
Johannes Pammer
Werner Brannath
Matthaeus Ch. Grasl
Boban M. Erovic
Publikationsdatum: 01.07.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 7/2014
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-013-2740-5

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

New diagnostic markers in salivary gland tumors

Abstract

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2014

Displacement of oropharyngeal structures during suction-swallowing cycles

New treatment strategies for HPV-positive head and neck cancer

MiR-155 up-regulation by LMP1 DNA contributes to increased nasopharyngeal carcinoma cell proliferation and migration

Salvage surgery for head and neck squamous cell carcinoma

Otoplasty: results of suturing and scoring techniques

Using temperature–time integration as a critical parameter in using monopolar radiofrequency ablations

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO