nach oben

European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.03.2016 | Head and Neck

A cost-effectiveness analysis of using TheraBite in a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy

verfasst von: Valesca P. Retèl, Lisette van der Molen, Lotte M. G. Steuten, Michiel W. van den Brekel, Frans J. M. Hilgers

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2016

Einloggen, um Zugang zu erhalten

Abstract

Previous studies have shown that a “Preventive Exercise Program” (PREP) is cost-effective compared to the standard exercise program provided in “Usual Care” (UC) in patients with advanced head and neck cancer. The current paper specifically estimates the cost-effectiveness of the TheraBite jaw rehabilitation device (TB) which is used as part of the PREP, compared to Speech Language Pathology (SLP) sessions as part of UC, and herewith intents to inform reimbursement discussions regarding the TheraBite device. Costs and outcomes [quality-adjusted life-years (QALYs)] of the TB compared to SLP were estimated using a Markov model of advanced head and neck cancer patients. Secondary outcome variables were trismus, feeding substitutes, facial pain, and pneumonia. The incremental cost-effectiveness ratio (ICER) was estimated from a health care perspective of the Netherlands, with a time horizon of 2 years. The total health care costs per patient were estimated to amount to €5,129 for the TB strategy and €6,915 for the SLP strategy. Based on the current data, the TB strategy yielded more quality-adjusted life-years (1.28) compared to the SLP strategy (1.24). Thus, the TB strategy seems more effective (+0.04) and less costly (−€1,786) than the SLP only strategy. At the prevailing threshold of €20,000/QALY the probability for the TB strategy being cost-effective compared to SLP was 70 %. To conclude, analysis of presently available data indicates that TB is expected to be cost-effective compared to SLP in a preventive exercise program for concomitant chemo-radiotherapy for advanced head and neck cancer patients.

Carnaby-Mann G, Crary MA, Schmalfuss I, Amdur R (2012) “Pharyngocise”: randomized controlled trial of preventative exercises to maintain muscle structure and swallowing function during head-and-neck chemoradiotherapy. Int J Radiat Oncol Biol Phys 83:210–219CrossRefPubMed

van der Molen L, van Rossum MA, Burkhead LM, Smeele LE, Rasch CR, Hilgers FJ (2011) A randomized preventive rehabilitation trial in advanced head and neck cancer patients treated with chemoradiotherapy: feasibility, compliance, and short-term effects. Dysphagia 26:155–170PubMedCentralCrossRefPubMed

Dijkstra PU, Huisman PM, Roodenburg JL (2006) Criteria for trismus in head and neck oncology. Int J Oral Maxillofac Surg 35:337–342CrossRefPubMed

Dijkstra PU, Sterken MW, Pater R, Spijkervet FK, Roodenburg JL (2007) Exercise therapy for trismus in head and neck cancer. Oral Oncol 43:389–394CrossRefPubMed

Dijkstra PU, Kalk WW, Roodenburg JL (2004) Trismus in head and neck oncology: a systematic review. Oral Oncol 40:879–889CrossRefPubMed

Epstein JB, Emerton S, Kolbinson DA, Le ND, Phillips N, Stevenson-Moore P, Osoba D (1999) Quality of life and oral function following radiotherapy for head and neck cancer. Head Neck 21:1–11CrossRefPubMed

Krennmair G, Ulm CW, Lenglinger F (2000) Effects of reduced mouth opening capacity (trismus) on pulmonary function. Int J Oral Maxillofac Surg 29:351–354CrossRefPubMed

Buchbinder D, Currivan RB, Kaplan AJ, Urken ML (1993) Mobilization regimens for the prevention of jaw hypomobility in the radiated patient: a comparison of three techniques. J Oral Maxillofac Surg 51:863–867CrossRefPubMed

Cohen EG, Deschler DG, Walsh K, Hayden RE (2005) Early use of a mechanical stretching device to improve mandibular mobility after composite resection: a pilot study. Arch Phys Med Rehabil 86:1416–1419CrossRefPubMed

10.

Kamstra JI, Roodenburg JL, Beurskens CH, Reintsema H, Dijkstra PU (2013) TheraBite exercises to treat trismus secondary to head and neck cancer. Support Care Cancer 21:951–957PubMedCentralCrossRefPubMed

11.

Burkhead LM, Sapienza CM, Rosenbek JC (2007) Strength-training exercise in dysphagia rehabilitation: principles, procedures, and directions for future research. Dysphagia 22:251–265CrossRefPubMed

12.

Retel VP, van der Molen L, Hilgers FJ, Rasch CR, L’Ortye AA, Steuten LM, van Harten WH (2011) A cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy. BMC Cancer 11:475PubMedCentralCrossRefPubMed

13.

van der Molen L, van Rossum MA, Rasch CR, Smeele LE, Hilgers FJ (2013) Two-year results of a prospective preventive swallowing rehabilitation trial in patients treated with chemoradiation for advanced head and neck cancer. Eur Arch Otorhinolaryngol 271(5):1257–1270CrossRefPubMed

14.

Ackerstaff AH, Balm AJ, Rasch CR, de Boer JP, Wiggenraad R, Rietveld DH, Gregor RT, Kroger R, Hilgers FJ (2009) First-year quality of life assessment of an intra-arterial (RADPLAT) versus intravenous chemoradiation phase III trial. Head Neck 31:77–84CrossRefPubMed

15.

Rasch CR, Hauptmann M, Schornagel J, Wijers O, Buter J, Gregor T, Wiggenraad R, de Boer JP, Ackerstaff AH, Kroger R, Hoebers FJ, Balm AJ, Hilgers FJ (2010) Intra-arterial versus intravenous chemoradiation for advanced head and neck cancer: results of a randomized phase 3 trial. Cancer 116:2159–2165CrossRefPubMed

16.

Bleichrodt H, Quiggin J (1999) Life-cycle preferences over consumption and health: when is cost-effectiveness analysis equivalent to cost-benefit analysis? J Health Econ 18:681–708CrossRefPubMed

17.

Torrance GW, Feeny D (1989) Utilities and quality-adjusted life years. Int J Technol Assess Health Care 5:559–575CrossRefPubMed

18.

Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350:1945–1952CrossRefPubMed

19.

Nguyen NP, Vos P, Moltz CC, Frank C, Millar C, Smith HJ, Dutta S, Alfieri A, Lee H, Martinez T, Karlsson U, Nguyen LM, Sallah S (2008) Analysis of the factors influencing dysphagia severity upon diagnosis of head and neck cancer. Br J Radiol 81:706–710CrossRefPubMed

20.

Langerman A, Maccracken E, Kasza K, Haraf DJ, Vokes EE, Stenson KM (2007) Aspiration in chemoradiated patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 133:1289–1295CrossRefPubMed

21.

Hakkaart-van Roijen L, Tan SS, Bouwmans-Frijters CAM (2010) Guide for research costs - Methods and standard cost prices for economic evaluations in healthcare \ commissioned by the Health Care Insurance Board. Rotterdam

22.

Sorgente, accessed September 2014: https://webwinkelsorgentel/indexphp?id_product=1010&controller=product

23.

Pauli N, Fagerberg-Mohlin B, Andrell P, Finizia C (2013) Exercise intervention for the treatment of trismus in head and neck cancer. Acta Oncol 53(4):502–509CrossRefPubMed

24.

Ramaekers BL, Joore MA, Grutters JP, van den Ende P, Jong J, Houben R, Lambin P, Christianen M, Beetz I, Pijls-Johannesma M, Langendijk JA (2011) The impact of late treatment-toxicity on generic health-related quality of life in head and neck cancer patients after radiotherapy. Oral Oncol 47:768–774CrossRefPubMed

25.

Elia M, Stratton RJ (2008) A cost-utility analysis in patients receiving enteral tube feeding at home and in nursing homes. Clin Nutr 27:416–423CrossRefPubMed

26.

Weinstein MC (2006) Recent developments in decision-analytic modelling for economic evaluation. Pharmacoeconomics 24:1043–1053CrossRefPubMed

27.

Fenwick E, Claxton K, Sculpher M (2001) Representing uncertainty: the role of cost-effectiveness acceptability curves. Health Econ 10:779–787CrossRefPubMed

28.

Briggs A, Claxton K, Sculpher M (2006) Decicion modelling for health economic evaluation. Oxford University Press, UK

29.

Pauli N, Johnson J, Finizia C, Andrell P (2013) The incidence of trismus and long-term impact on health-related quality of life in patients with head and neck cancer. Acta Oncol 52:1137–1145CrossRefPubMed

30.

Gourin CG, Couch ME, Johnson JT (2014) Effect of weight loss on short-term outcomes and costs of care after head and neck cancer surgery. Ann Otol Rhinol Laryngol 123:101–110CrossRefPubMed

31.

Melchers LJ, Van WE, Beurskens CH, Reintsema H, Slagter AP, Roodenburg JL, Dijkstra PU (2009) Exercise adherence in patients with trismus due to head and neck oncology: a qualitative study into the use of the Therabite. Int J Oral Maxillofac Surg 38:947–954CrossRefPubMed

32.

Pauli N, Andrell P, Johansson M, Fagerberg-Mohlin B, Finizia C (2014) Treating trismus: a prospective study on effect and compliance to jaw exercise therapy in head and neck cancer. Head Neck. doi:10.1002/hed.23818

Titel: A cost-effectiveness analysis of using TheraBite in a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy
verfasst von: Valesca P. Retèl
Lisette van der Molen
Lotte M. G. Steuten
Michiel W. van den Brekel
Frans J. M. Hilgers
Publikationsdatum: 01.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-015-3541-9

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

A cost-effectiveness analysis of using TheraBite in a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy

Abstract

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2016

Health-related quality of life and mental distress in patients with partial deafness: preliminary findings

Clinical applications of dual-energy CT in head and neck imaging

The nasal vestibular body: anatomy, clinical features, and treatment considerations

Two rare cases of laryngeal intralymphatic histiocytosis

Frequent chromosomal aberrations and candidate genes in head and neck squamous cell carcinoma

The possible preventive effect of caffeic acid phenethyl ester (CAPE) against myringosclerosis

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO