Skip to main content
Erschienen in: European Archives of Oto-Rhino-Laryngology 3/2016

01.03.2016 | Rhinology

Radiation therapy for nasal vestibule squamous cell carcinoma: a 40-year experience

verfasst von: Justin Wray, Christopher G. Morris, Jessica M. Kirwan, Robert J. Amdur, John W. Werning, Peter T. Dziegielewski, William M. Mendenhall

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2016

Einloggen, um Zugang zu erhalten

Abstract

We evaluated the treatment of squamous cell carcinoma (SCC) of the nasal vestibule. Eighty-six patients were treated with radiotherapy (RT) and 13 patients received surgery and RT. The mean follow-up was: 9.7 years (range 4 months–35.9 years). The 5- and 10-year outcomes were: local control (LC), 88 and 82 %; local–regional control (LRC), 78 and 73 %; freedom from distant metastases (FFDM), 96 and 96 %; cause-specific survival (CSS), 91 and 86 %; and overall survival, 75 and 51 %. The 5- and 10-year LC rates for patients treated with RT were 94 and 89 % overall. A multivariate analysis was performed. Tumor size predicted LC, LRC, OS, and CSS. Overall stage predicted LRC. RT cures most patients with T1–T2 and favorable T4 SCCs with acceptable toxicity. RT and surgery result in improved likelihood of cure for patients with advanced T4 lesions.
Literatur
1.
Zurück zum Zitat American Joint Committee on Cancer (2011) Skin. In: Edge SB, Byrd, Compton CC, Fritz AG, Greene FL, Trotti A (eds) AJCC Cancer Staging Manual, 7th edn. Springer, Chicago, pp 299–344 American Joint Committee on Cancer (2011) Skin. In: Edge SB, Byrd, Compton CC, Fritz AG, Greene FL, Trotti A (eds) AJCC Cancer Staging Manual, 7th edn. Springer, Chicago, pp 299–344
2.
Zurück zum Zitat American Joint Committee on Cancer (2002) Skin. In: Greene FL, Page DL, Fleming ID et al (eds) AJCC Cancer Staging Manual, 6th edn. Springer, Chicago, pp 201–220 American Joint Committee on Cancer (2002) Skin. In: Greene FL, Page DL, Fleming ID et al (eds) AJCC Cancer Staging Manual, 6th edn. Springer, Chicago, pp 201–220
3.
Zurück zum Zitat Wang CC (1976) Treatment of carcinoma of the nasal vestibule by irradiation. Cancer 38(1):100–106CrossRefPubMed Wang CC (1976) Treatment of carcinoma of the nasal vestibule by irradiation. Cancer 38(1):100–106CrossRefPubMed
5.
Zurück zum Zitat Horsmans JD, Godballe C, Jorgensen KE, Bastholt L, Lontoft E (1999) Squamous cell carcinoma of the nasal vestibule. Rhinology 37(3):117–121PubMed Horsmans JD, Godballe C, Jorgensen KE, Bastholt L, Lontoft E (1999) Squamous cell carcinoma of the nasal vestibule. Rhinology 37(3):117–121PubMed
6.
Zurück zum Zitat Kummer E, Rasch CR, Keus RB, Tan IB, Balm AJ (2002) T stage as prognostic factor in irradiated localized squamous cell carcinoma of the nasal vestibule. Head Neck 24(3):268–273. doi:10.1002/hed.10023 CrossRefPubMed Kummer E, Rasch CR, Keus RB, Tan IB, Balm AJ (2002) T stage as prognostic factor in irradiated localized squamous cell carcinoma of the nasal vestibule. Head Neck 24(3):268–273. doi:10.​1002/​hed.​10023 CrossRefPubMed
7.
Zurück zum Zitat Agger A, von Buchwald C, Madsen AR, Yde J, Lesnikova I, Christensen CB, Foghsgaard S, Christensen TB, Hansen HS, Larsen S, Bentzen J, Andersen E, Andersen L, Grau C (2009) Squamous cell carcinoma of the nasal vestibule 1993–2002: a nationwide retrospective study from DAHANCA. Head Neck 31(12):1593–1599. doi:10.1002/hed.21132 CrossRefPubMed Agger A, von Buchwald C, Madsen AR, Yde J, Lesnikova I, Christensen CB, Foghsgaard S, Christensen TB, Hansen HS, Larsen S, Bentzen J, Andersen E, Andersen L, Grau C (2009) Squamous cell carcinoma of the nasal vestibule 1993–2002: a nationwide retrospective study from DAHANCA. Head Neck 31(12):1593–1599. doi:10.​1002/​hed.​21132 CrossRefPubMed
9.
Zurück zum Zitat Levendag PC, Nijdam WM, van Moolenburgh SE, Tan L, Noever I, van Rooy P, Mureau MA, Jansen PP, Munte K, Hofer SO (2006) Interstitial radiation therapy for early-stage nasal vestibule cancer: a continuing quest for optimal tumor control and cosmesis. Int J Radiat Oncol Biol Phys 66(1):160–169 (pii: S0360-3016(06)00533-5)CrossRefPubMed Levendag PC, Nijdam WM, van Moolenburgh SE, Tan L, Noever I, van Rooy P, Mureau MA, Jansen PP, Munte K, Hofer SO (2006) Interstitial radiation therapy for early-stage nasal vestibule cancer: a continuing quest for optimal tumor control and cosmesis. Int J Radiat Oncol Biol Phys 66(1):160–169 (pii: S0360-3016(06)00533-5)CrossRefPubMed
10.
Zurück zum Zitat Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350(19):1945–1952. doi:10.1056/NEJMoa032641 CrossRefPubMed Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, Cognetti F, Bourhis J, Kirkpatrick A, van Glabbeke M (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350(19):1945–1952. doi:10.​1056/​NEJMoa032641 CrossRefPubMed
11.
Zurück zum Zitat Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, Machtay M, Ensley JF, Chao KS, Schultz CJ, Lee N, Fu KK (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350(19):1937–1944. doi:10.1056/NEJMoa032646 CrossRefPubMed Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, Machtay M, Ensley JF, Chao KS, Schultz CJ, Lee N, Fu KK (2004) Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350(19):1937–1944. doi:10.​1056/​NEJMoa032646 CrossRefPubMed
12.
Zurück zum Zitat Lewis CM, Glisson BS, Feng L, Wan F, Tang X, Wistuba II, El-Naggar AK, Rosenthal DI, Chambers MS, Lustig RA, Weber RS (2012) A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck. Clin Cancer Res 18(5):1435–1446. doi:10.1158/1078-0432.CCR-11-1951 CrossRefPubMed Lewis CM, Glisson BS, Feng L, Wan F, Tang X, Wistuba II, El-Naggar AK, Rosenthal DI, Chambers MS, Lustig RA, Weber RS (2012) A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck. Clin Cancer Res 18(5):1435–1446. doi:10.​1158/​1078-0432.​CCR-11-1951 CrossRefPubMed
Metadaten
Titel
Radiation therapy for nasal vestibule squamous cell carcinoma: a 40-year experience
verfasst von
Justin Wray
Christopher G. Morris
Jessica M. Kirwan
Robert J. Amdur
John W. Werning
Peter T. Dziegielewski
William M. Mendenhall
Publikationsdatum
01.03.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-015-3603-z

Weitere Artikel der Ausgabe 3/2016

European Archives of Oto-Rhino-Laryngology 3/2016 Zur Ausgabe

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.