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European Archives of Oto-Rhino-Laryngology

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09.12.2016 | Head and Neck

Recurrent oropharyngeal cancer after organ preserving treatment: pattern of failure and survival

verfasst von: M. de Ridder, Z. A. R. Gouw, J. J. Sonke, A. Navran, B. Jasperse, J. Heukelom, M. E. T. Tesselaar, W. M. C. Klop, M. W. M. van den Brekel, Abrahim Al-Mamgani

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2017

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Abstract

The objectives is to thoroughly analyze the pattern of failure and oncologic outcome in recurrent oropharyngeal cancer (OPC) after (chemo)radiotherapy and correlate the site of failure to the planned radiation dose. Between January 2010 and April 2014, 57 patients with recurrent OPC after (chemo)radiotherapy were analyzed. Endpoints were pattern of failure and overall survival (OS). Local (LF) and regional failure (RF) were classified as in-field [>50% within gross tumor volume (GTV)], marginal [<50% within GTV but >50% within clinical target volume (CTV)], or out-of-field (>50% outside CTV) recurrences. In the whole group, 70 recurrences were reported. Of the 31 LF, 29 (93.5%) were in-field and 2 (6.5%) were marginal. No out-field LF was reported. Of the 21 RF, 13 RF (62%) were in-field, 6 (28.5%) marginal, and 2 (9.5%) out-of-field recurrences. Forty-three percent of RF was developed in an electively treated neck level, and 2 of them were contralateral. OS at 2 years in recurrent HPV positive, compared to HPV-negative OPC, were 66 and 18%, respectively (p = 0.011). OS was also significantly better in patients that were salvage treatment which was possible (70 vs. 6%, p < 0.001). Median survival after distant failure was 3.6 months. The great majority of LFs were located within the GTV and 43% of RFs developed in an electively treated neck level. The currently used margins and dose recipe and the indication for bilateral nodal irradiation need to be reevaluated. OS was significantly better in recurrent HPV-positive OPC and in patients, where salvage treatment was possible.

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Titel: Recurrent oropharyngeal cancer after organ preserving treatment: pattern of failure and survival
verfasst von: M. de Ridder
Z. A. R. Gouw
J. J. Sonke
A. Navran
B. Jasperse
J. Heukelom
M. E. T. Tesselaar
W. M. C. Klop
M. W. M. van den Brekel
Abrahim Al-Mamgani
Publikationsdatum: 09.12.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2017
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4413-7

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Recurrent oropharyngeal cancer after organ preserving treatment: pattern of failure and survival

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Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

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