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European Archives of Oto-Rhino-Laryngology

Erschienen in:

16.12.2016 | Review Article

The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma

verfasst von: Shumin Xie, Xiaoli Wang, Jihao Ren, Wei Liu

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 5/2017

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Abstract

Cholesteatoma is a destructive squamous epithelial lesion of the temporal bone which gradually expands and leads to serious complications by destruction of nearby bony structures. Erosion caused by bone resorption of the ossicular chain and bony labyrinth may result in hearing loss, vestibular dysfunction, facial paralysis, labyrinthine fistulae and intracranial complications. The exact underlying cellular and molecular mechanism of bone resorption in acquired cholesteatoma still remains unexplained. Pubmed database and China National Knowledge Infrastructure were screened for articles focusing on bone resorption in acquired cholesteatoma. Osteoclast activation, pressure necrosis, acid lysis, enzyme mediation, inflammatory mediators and several newly discovered biomolecules are outlined as main theories behind bone resorption in acquired cholesteatoma, aiming to facilitate the development of potential therapeutic targets for preventing intracranial and extracranial complications caused by bone resorption in acquired middle ear cholesteatoma.

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Titel: The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma
verfasst von: Shumin Xie
Xiaoli Wang
Jihao Ren
Wei Liu
Publikationsdatum: 16.12.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 5/2017
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-4422-6

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The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma

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