Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Archives of Oto-Rhino-Laryngology
Erschienen in: European Archives of Oto-Rhino-Laryngology 12/2017

19.09.2017 | Review Article

Therapeutic modalities and oncologic outcomes in the treatment of T1b glottic squamous cell carcinoma: a systematic review

verfasst von: Federico Maria Gioacchini, Michele Tulli, Shaniko Kaleci, Stefano Bondi, Mario Bussi, Massimo Re

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 12/2017

Einloggen, um Zugang zu erhalten

Abstract

T1a and T1b glottic squamous cell carcinoma (SCC) are often analyzed together by authors who investigate the oncologic outcomes achieved after different therapeutic options. Nevertheless, T1b definitely represents a more advanced tumor stage compared to T1a glottic SCC. The objective of this review was first to analyze the overall success rates in the treatment of patients affected by T1b glottic SCC. Moreover, a subgroup analysis was planned to specifically compare the outcomes obtained with radiotherapy (RT), transoral laser microsurgery (TLM) and open partial laryngectomies (OPL). An electronic library search of the relevant English literature was performed. Potentially eligible articles were reviewed. Qualified articles were selected and evaluated. Fifty-two studies comprising 2360 patients were included. The overall rate of disease-free survival (DFS) was 85% (95% CI 83–87). The overall rate of overall survival was 85% (95% CI 80–88) while the rate of disease-specific survival (DSS) was found to be 96% (95% CI 90–98). Statistical data concerning outcomes for each therapeutic modality showed an higher DFS rate for subjects treated with RT and OPL, respectively, 87% (95% CI 0.85–0.89) and 83% (95% CI 0.78–0.89), when compared to those who underwent TLM 77% (95% CI 0.69–0.83). In conclusion, our results showed a high level of overall DSS (96%) for patients affected by T1b glottic SCC. Regarding the specific therapeutic options, our subgroup analysis showed as patients treated with TLM present a higher rate of oncological recurrence in comparison to those who underwent RT or OPL. Nevertheless, on the basis of our data it was also noted that no significant differences subsist in terms of survival rates among the three different treatments. Moreover, the absence of a comparative analysis useful to confirm these conclusions must be considered.
Literatur
1.
Rettig EM, D’Souza G (2015) Epidemiology of head and neck cancer. Surg Oncol Clin N Am 24(3):379–396CrossRefPubMed
2.
Abdurehim Y, Hua Z, Yasin Y, Xukurhan A, Imam I, Yuqin F (2012) Transoral laser surgery versus radiotherapy: systematic review and meta-analysis for treatment options of T1a glottic cancer. Head Neck 34(1):23–33CrossRefPubMed
3.
Dinapoli N, Parrilla C, Galli J, Autorino R, Miccichè F, Bussu F, Balducci M, D’Alatri L, Marchese R, Rigante M, Di Lella G, Liberati L, Almadori G, Paludetti G, Valentini V (2010) Multidisciplinary approach in the treatment of T1 glottic cancer. The role of patient preference in a homogenous patient population. Strahlenther Onkol 186(11):607–613CrossRefPubMed
4.
Marcotullio D, de Vincentiis M, Iannella G, Bigelli C, Magliulo G (2014) Surgical treatment of T1b glottic tumor, 10-years follow-up. Eur Rev Med Pharmacol Sci 18(8):1212–1217PubMed
5.
Remmelts AJ, Hoebers FJ, Klop WM, Balm AJ, Hamming-Vrieze O, van den Brekel MW (2013) Evaluation of laser surgery and radiotherapy as treatment modalities in early stage laryngeal carcinoma: tumour outcome and quality of voice. Eur Arch Otorhinolaryngol 270(7):2079–2087CrossRefPubMed
6.
Szyfter W, Leszczyńska M, Wierzbicka M, Kopeć T, Bartochowska A (2013) Value of open horizontal glottectomy in the treatment for T1b glottic cancer with anterior commissure involvement. Head Neck 35(12):1738–1744CrossRefPubMed
7.
Rödel RM, Steiner W, Müller RM, Kron M, Matthias C (2009) Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure. Head Neck 31(5):583–592CrossRefPubMed
8.
Kirchner JA, Carter D (1987) Intralaryngeal barriers to the spread of cancer. Acta Otolaryngol (Stockh) 103:503–513
9.
Bagatella F, Bignardi L (1981) Morphological study of the laryngeal anterior commissure with regard to the spread of cancer. Acta Otolaryngol (Stockh) 92:167–171CrossRef
10.
Lee HS, Chun BG, Kim SW, Kim ST, Oh JH, Hong JC, Lee KD (2013) Transoral laser microsurgery for early glottic cancer as one-stage single-modality therapy. Laryngoscope 123(11):2670–2674CrossRefPubMed
11.
Higgins J, Thompson S, Deeks J, Altman D (2002) Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice. J Health Serv Res Policy 7:51–61CrossRefPubMed
12.
13.
Warner L, Chudasama J, Kelly CG, Loughran S, McKenzie K, Wight R, Dey P (2014) Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database Syst Rev 12:CD002027
14.
Feng Y, Wang B, Wen S (2011) Laser surgery versus radiotherapy for T1–T2N0 glottic cancer: a meta-analysis. ORL J Otorhinolaryngol Relat Spec 73(6):336–342CrossRefPubMed
15.
Hartl DM, Ferlito A, Brasnu DF, Langendijk JA, Rinaldo A, Silver CE, Wolf GT (2011) Evidence-based review of treatment options for patients with glottic cancer. Head Neck 33(11):1638–1648CrossRefPubMed
16.
Higgins KM (2011) What treatment for early-stage glottic carcinoma among adult patients: CO2 endolaryngeal laser excision versus standard fractionated external beam radiation is superior in terms of cost utility? Laryngoscope 121(1):116–134CrossRefPubMed
17.
Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB (2004) Management of T1–T2 glottic carcinomas. Cancer 100(9):1786–1792CrossRefPubMed
18.
Yoo J, Lacchetti C, Hammond JA, Gilbert RW, Head and Neck Cancer Disease Site Group (2014) Role of endolaryngeal surgery (with or without laser) versus radiotherapy in the management of early (T1) glottic cancer: a systematic review. Head Neck 36(12):1807–1819CrossRefPubMed
19.
O’Hara J, Markey A, Homer JJ (2013) Transoral laser surgery versus radiotherapy for tumour stage 1a or 1b glottic squamous cell carcinoma: systematic review of local control outcomes. J Laryngol Otol 127(8):732–738CrossRefPubMed
20.
Chone CT, Yonehara E, Martins JE, Altemani A, Crespo AN (2007) Importance of anterior commissure in recurrence of early glottic cancer after laser endoscopic resection. Arch Otolaryngol Head Neck Surg 133(9):882–887CrossRefPubMed
21.
Hakeem AH, Tubachi J, Pradhan SA (2013) Significance of anterior commissure involvement in early glottic squamous cell carcinoma treated with trans-oral CO2 laser microsurgery. Laryngoscope 123(8):1912–1917CrossRefPubMed
22.
Sachse F, Stoll W, Rudack C (2009) Evaluation of treatment results with regard to initial anterior commissure involvement in early glottic carcinoma treated by external partial surgery or transoral laser microresection. Head Neck 31(4):531–537CrossRefPubMed
23.
Tamaki Y, Hieda Y, Yoshida R, Yoshizako T, Fuchiwaki T, Aoi N, Sekihara K, Kitajima K, Kawauchi H, Kitagaki H, Sasaki R, Inomata T (2015) Short treatment time and excellent treatment outcome in accelerated hyperfractionated radiotherapy for T1 glottic cancer. Nagoya J Med Sci 77(4):585–594PubMedPubMedCentral
24.
Hoffmann C, Cornu N, Hans S, Sadoughi B, Badoual C, Brasnu D (2016) Early glottis cancer involving the anterior commissure treated by transoral laser cordectomy. Laryngoscope 126(8):1817–1822CrossRefPubMed
25.
Ermiş E, Teo M, Dyker KE, Fosker C, Sen M, Prestwich RJ (2015) Definitive hypofractionated radiotherapy for early glottic carcinoma: experience of 55 Gy in 20 fractions. Radiat Oncol 23(10):203CrossRef
26.
Harada A, Sasaki R, Miyawaki D, Yoshida K, Nishimura H, Ejima Y, Kitajima K, Saito M, Otsuki N, Nibu K (2015) Treatment outcomes of the patients with early glottic cancer treated with initial radiotherapy and salvaged by conservative surgery. Jpn J Clin Oncol 45(3):248–255CrossRefPubMed
27.
Lei WB, Jiang AY, Chai LP, Zhu XL, Wang ZF, Wen YH, Su ZZ, Wen WP (2013) Middle frontal horizontal partial laryngectomy (MFHPL): a treatment for stage T1b squamous cell carcinoma of the glottic larynx involving anterior vocal commissure. PLoS ONE 8(1):e52723CrossRefPubMedPubMedCentral
28.
Khan MK, Koyfman SA, Hunter GK, Reddy CA, Saxton JP (2012) Definitive radiotherapy for early (T1–T2) glottic squamous cell carcinoma: a 20 year Cleveland clinic experience. Radiat Oncol 19(7):193CrossRef
29.
Hirasawa N, Itoh Y, Naganawa S, Ishihara S, Suzuki K, Koyama K, Murao T, Asano A, Nomoto Y, Horikawa Y, Sasaoka M, Obata Y (2012) Multi-institutional analysis of early glottic cancer from 2000 to 2005. Radiat Oncol 1(7):122CrossRef
30.
Tong CC, Au KH, Ngan RK, Cheung FY, Chow SM, Fu YT, Au JS, Law SC (2012) Definitive radiotherapy for early stage glottic cancer by 6 MV photons. Head Neck Oncol 4:23CrossRefPubMedPubMedCentral
31.
Gultekin M, Ozyar E, Cengiz M, Ozyigit G, Hayran M, Hosal S, Akyol F (2012) High daily fraction dose external radiotherapy for T1 glottic carcinoma: treatment results and prognostic factors. Head Neck 34(7):1009–1014CrossRefPubMed
32.
Manzo R, Ravo V, Murino P, Morra A, Panetti G, Laudati A, Prisco A, Panelli G, Muto P (2010) Outcomes of radiation therapy for T1 glottic carcinoma from an Italian regional series with doses ranging from 60 to 66 Gy. Tumori 96(4):577–581PubMed
33.
Chera BS, Amdur RJ, Morris CG, Kirwan JM, Mendenhall WM (2010) T1N0 to T2N0 squamous cell carcinoma of the glottic larynx treated with definitive radiotherapy. Int J Radiat Oncol Biol Phys 78(2):461–466CrossRefPubMed
34.
Jones DA, Mendenhall CM, Kirwan J, Morris CG, Donnan A, Holwerda S, Kraus ST, Mann CJ, Grant JR, Donnan B, Mendenhall WM (2010) Radiation therapy for management of t1–t2 glottic cancer at a private practice. Am J Clin Oncol 33(6):587–590CrossRefPubMed
35.
Nomiya T, Nemoto K, Wada H, Takai Y, Yamada S (2008) Long-term results of radiotherapy for T1a and T1bN0M0 glottic carcinoma. Laryngoscope 118(8):1417–1421CrossRefPubMed
36.
Motta G, Esposito E, Motta S, Tartaro G, Testa D (2005) CO2 laser surgery in the treatment of glottic cancer. Head Neck 27(8):733CrossRefPubMed
37.
Thariat J, Bruchon Y, Bonnetain F, Barillot I, Truc G, Peignaux K, Horiot JC, Maingon P (2004) Conservative treatment of early glottic carcinomas with exclusive radiotherapy. Cancer Radiother 8(5):288–296CrossRefPubMed
38.
Steiner W, Ambrosch P, Rödel RM, Kron M (2004) Impact of anterior commissure involvement on local control of early glottic carcinoma treated by laser microresection. Laryngoscope 114(8):1485–1491CrossRefPubMed
39.
Zouhair A, Azria D, Coucke P, Matzinger O, Bron L, Moeckli R, Do HP, Mirimanoff RO, Ozsahin M (2004) Decreased local control following radiation therapy alone in early-stage glottic carcinoma with anterior commissure extension. Strahlenther Onkol 180(2):84–90CrossRefPubMed
40.
Mendenhall WM, Amdur RJ, Morris CG, Hinerman RW (2001) T1–T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 19(20):4029–4036CrossRefPubMed
41.
Pignataro L, Capaccio P, Neglia CB, Ottaviani A (2000) Clinical experience with the treatment of T1b glottic cancer by means of horizontal glottectomy. Eur Arch Otorhinolaryngol 257(4):216–218CrossRefPubMed
42.
Spector JG, Sessions DG, Chao KS, Haughey BH, Hanson JM, Simpson JR, Perez CA (1999) Stage I (T1 N0 M0) squamous cell carcinoma of the laryngeal glottis: therapeutic results and voice preservation. Head Neck 21(8):707–717CrossRefPubMed
43.
Burke LS, Greven KM, McGuirt WT, Case D, Hoen HM, Raben M (1997) Definitive radiotherapy for early glottic carcinoma: prognostic factors and implications for treatment. Int J Radiat Oncol Biol Phys 38(5):1001–1006CrossRefPubMed
44.
Sjögren EV, Wiggenraad RG, Le Cessie S, Snijder S, Pomp J, Baatenburg de Jong RJ (2009) Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. Eur Arch Otorhinolaryngol 266(5):735–744CrossRefPubMed
45.
Reddy SP, Hong RL, Nagda S, Emami B (2007) Effect of tumor bulk on local control and survival of patients with T1 glottic cancer: a 30-year experience. Int J Radiat Oncol Biol Phys 69(5):1389–1394CrossRefPubMed
46.
Cellai E, Frata P, Magrini SM, Paiar F, Barca R, Fondelli S, Polli C, Livi L, Bonetti B, Vitali E, De Stefani A, Buglione M, Biti G (2005) Radical radiotherapy for early glottic cancer: results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease. Int J Radiat Oncol Biol Phys 63(5):1378–1386CrossRefPubMed
47.
Warde P, O’Sullivan B, Bristow RG, Panzarella T, Keane TJ, Gullane PJ, Witterick IP, Payne D, Liu FF, McLean M, Waldron J, Cummings BJ (1998) T1/T2 glottic cancer managed by external beam radiotherapy: the influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol Phys 41(2):347–353CrossRefPubMed
48.
Nishimura Y, Nagata Y, Okajima K, Mitsumori M, Hiraoka M, Masunaga S, Ono K, Shoji K, Kojima H (1996) Radiation therapy for T1, 2 glottic carcinoma: impact of overall treatment time on local control. Radiother Oncol 40(3):225–232CrossRefPubMed
49.
Inoue T, Matayoshi Y, Inoue T, Ikeda H, Teshima T, Murayama S (1993) Prognostic factors in telecobalt therapy for early supraglottic carcinoma. Cancer 72(1):57–61CrossRefPubMed
50.
Cheah NL, Lupton S, Marshall A, Hartley A, Glaholm J (2009) Outcome of T1N0M0 squamous cell carcinoma of the larynx treated with short-course radiotherapy to a total dose of 50 Gy in 16 fractions: the Birmingham experience. Clin Oncol (R Coll Radiol) 21(6):494–501CrossRef
51.
Gowda RV, Henk JM, Mais KL, Sykes AJ, Swindell R, Slevin NJ (2003) Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital experience. Radiother Oncol 68(2):105–111CrossRefPubMed
52.
Jin J, Liao Z, Gao L, Huang X, Xu G (2002) Analysis of prognostic factors for T(1)N(0)M(0) glottic cancer treated with definitive radiotherapy alone: experience of the cancer hospital of Peking Union Medical College and the Chinese Academy of Medical Sciences. Int J Radiat Oncol Biol Phys 54(2):471–478CrossRefPubMed
53.
Lee JH, Machtay M, McKenna MG, Weinstein GS, Markiewicz DA, Krisch RE, Kligerman MM (2001) Radiotherapy with 6-megavolt photons for early glottic carcinoma: potential impact of extension to the posterior vocal cord. Am J Otolaryngol 22(1):43–54 (review) CrossRefPubMed
54.
Mendelsohn AH, Kiagiadaki D, Lawson G, Remacle M (2015) CO2 laser cordectomy for glottic squamous cell carcinoma involving the anterior commissure: voice and oncologic outcomes. Eur Arch Otorhinolaryngol 272(2):413–418CrossRefPubMed
55.
Moon SH, Cho KH, Chung EJ, Lee CG, Lee KC, Chai GY, Kang KM, Lee JY, Chung WK, Park WY, Kim JH (2014) A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1–2 glottic squamous cell carcinomas: results of a Korean Radiation Oncology Group (KROG-0201) study. Radiother Oncol 110(1):98–103CrossRefPubMed
56.
Yamazaki H, Nishiyama K, Tanaka E, Koizumi M, Chatani M (2006) Radiotherapy for early glottic carcinoma (T1N0M0): results of prospective randomized study of radiation fraction size and overall treatment time. Int J Radiat Oncol Biol Phys 64(1):77–82CrossRefPubMed
57.
Franchin G, Minatel E, Gobitti C, Talamini R, Sartor G, Caruso G, Grando G, Politi D, Gigante M, Toffoli G, Trovò MG, Barzan L (1998) Radiation treatment of glottic squamous cell carcinoma, stage I and II: analysis of factors affecting prognosis. Int J Radiat Oncol Biol Phys 40(3):541–548CrossRefPubMed
58.
Narayana A, Vaughan AT, Kathuria S, Fisher SG, Walter SA, Reddy SP (2000) P53 overexpression is associated with bulky tumor and poor local control in T1 glottic cancer. Int J Radiat Oncol Biol Phys 46(1):21–26CrossRefPubMed
59.
Foote RL, Buskirk SJ, Grado GL, Bonner JA (1997) Has radiotherapy become too expensive to be considered a treatment option for early glottic cancer? Head Neck 19(8):692–700CrossRefPubMed
60.
Motta G, Esposito E, Cassiano B, Motta S (1997) T1–T2–T3 glottic tumors: fifteen years experience with CO2 laser. Acta Otolaryngol Suppl 527:155–159CrossRefPubMed
61.
Rucci L, Gallo O, Fini-Storchi O (1991) Glottic cancer involving anterior commissure: surgery vs radiotherapy. Head Neck 13(5):403–410CrossRefPubMed
62.
Chatani M, Matayoshi Y, Masaki N (1993) Radiation therapy for larynx carcinoma: long-term results of stage I glottic carcinoma. Strahlenther Onkol 169(2):102–106PubMed
63.
Chatani M, Matayoski Y, Masaki N, Teshima T, To I (1996) Radiation therapy for early glottic carcinoma (T1N0M0). The final results of prospective randomized study concerning radiation field. Strahlenther Onkol. 172(3):169–172 (erratum in: Strahlenther Onkol 1996;172(9):524) PubMed
64.
Dedivitis RA, Guimarães AV, Guirado CR (2005) Outcome after partial frontolateral laryngectomy. Int Surg 90(2):113–118PubMed
65.
Krawczyk J, Svoboda V, Foster L (1991) The influence of some factors on local control of early glottic cancer. Clin Oncol (R Coll Radiol) 3(6):330–334CrossRef
66.
Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR (1988) T1–T2 vocal cord carcinoma: a basis for comparing the results of radiotherapy and surgery. Head Neck Surg. 10(6):373–377CrossRefPubMed
67.
Nozaki M, Furuta M, Murakami Y, Izawa Y, Iwasaki N, Takahashi H, Watanabe K (2000) Radiation therapy for T1 glottic cancer: involvement of the anterior commissure. Anticancer Res. 20(2B):1121–1124PubMed
68.
Hirasawa N, Itoh Y, Ishihara S, Kubota S, Itoh J, Fujimoto Y, Nakashima T, Naganawa S (2010) Radiotherapy with or without chemotherapy for patients with T1–T2 glottic carcinoma: retrospective analysis. Head Neck Oncol 2:20CrossRefPubMedPubMedCentral
Metadaten
Titel
Therapeutic modalities and oncologic outcomes in the treatment of T1b glottic squamous cell carcinoma: a systematic review
verfasst von
Federico Maria Gioacchini
Michele Tulli
Shaniko Kaleci
Stefano Bondi
Mario Bussi
Massimo Re
Publikationsdatum
19.09.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 12/2017
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-017-4736-z

Weitere Artikel der Ausgabe 12/2017

European Archives of Oto-Rhino-Laryngology 12/2017 Zur Ausgabe

Editorial

Deep lobe parotidectomy—why, when, and how?

Otology

Cochlear implantation with the nucleus slim modiolar electrode (CI532): a preliminary experience

Head and Neck

Palatal ancient schwannoma: optical, immunohistochemical and ultrastructural study with literature review

Letter to the Editor

In reference to “The transotic approach for vestibular schwannoma: indications and results”

Rhinology

Management of maxillary sinus inverted papilloma via endoscopic partial medial maxillectomy with an inferior turbinate reversing approach

Otology

CO2 laser stapedotomy safety: influence of laser energy and time on bone-conduction hearing levels

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

HNO-Op. auch mit über 90?

16.04.2024 | Tonsillektomie | Nachrichten

Intrakapsuläre Tonsillektomie gewinnt an Boden

15.04.2024 | Hörsturz | Nachrichten

Bilateraler Hörsturz hat eine schlechte Prognose

13.04.2024 | Klinik aktuell | Kongressbericht | Nachrichten

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“
weitere anzeigen

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen