Introduction
Materials and methods
Human postmortem tissue
Code | Diagnosis (2 = co) | DSM IV | Age (years) | Age at onset (years) | Gender | Duration of disease (years) | Hospitalization (years) | Duration of medication (years) | Atyp–typ | CPE last dose (mg) | CPE last 10 years (kg) |
---|---|---|---|---|---|---|---|---|---|---|---|
01/00 | 1 | 295.6 | 51 | 23 | M | 28 | 17 | 25 | 2 | 450 | 1.8 |
13/00 | 1 | 295.6 | 64 | 16 | F | 48 | 21 | 45 | 3 | 1,536 | 7.7 |
35/00 | 1 | 295.6 | 64 | 24 | F | 41 | 5 | 40 | 2 | 54.5 | 4.6 |
46/00 | 1 | 295.6 | 63 | 24 | F | 40 | 30 | 30 | 3 | 75 | 1.8 |
50/01 | 1 | 295.6 | 81 | 19 | M | 62 | 48 | 50 | 1 | 92.8 | 1.4 |
83/01 | 1 | 295.6 | 71 | 30 | M | 40 | 12 | 35 | 1 | 782.4 | 10 |
36/02 | 1 | 295.6 | 73 | 30 | M | 43 | 33 | 40 | 1 | 507.4 | 1.7 |
39/02 | 1 | 295.6 | 43 | 20 | M | 22 | 13 | 20 | 3 | 464 | 2.6 |
39/03 | 1 | 295.6 | 77 | 28 | F | 49 | 48 | 48 | 2 | 2,555 | 8.3 |
43/03 | 1 | 295.6 | 76 | 27 | F | 49 | 30 | 47 | 1 | 300 | 4.9 |
43/01 | 2 | 91 | F | ||||||||
61/01 | 2 | 66 | M | ||||||||
002/02 | 2 | 41 | M | ||||||||
51/02 | 2 | 57 | M | ||||||||
57/02 | 2 | 53 | M | ||||||||
59/02 | 2 | 63 | M | ||||||||
72/02 | 2 | 79 | M | ||||||||
RZ77 | 2 | 57 | M | ||||||||
RZ84 | 2 | 50 | M | ||||||||
RZ99 | 2 | 55 | F |
Code | Cause of death | PMI (h) | R.I.N. value | Brain Weight (g) | CSF pH | Last medication | Last medication | Cigarettes | Alcohol | ECT |
---|---|---|---|---|---|---|---|---|---|---|
01/00 | Heart infarction | 12 | 6.8 | 1380 | 6.7 | Clozapine 500 mg | 30/day | No | No | |
13/00 | Pulmonary insufficiency | 11 | 6.9 | 1180 | 7 | Clozapine 500 mg | Haloperidol 40 mg, Ciatyl 40 mg | 0 | No | Yes |
35/00 | Heart infarction | 23 | 7.6 | 1250 | 6.6 | Zotepine 150 mg | Olanzapine 10 mg | 20/day | No | Yes |
46/00 | Heart infarction | 31 | 6.1 | 1240 | 6.3 | Olanzapine 15 mg | 30/day | No | Yes | |
50/01 | Cor pulmonale, heart insufficiency | 4 | 6 | 1390 | 6.8 | Haloperidol 4 mg | Prothipendyl 80 mg | 20/day | No | No |
83/01 | Heart infarction | 28 | 5.9 | 1480 | 6.5 | Haloperidol 32 mg | Pipamperone 40 mg | 40/day | No | No |
36/02 | Heart infarction | 20 | 7.1 | 1330 | 6.9 | Perphenazine 32 mg | Promethazine 150 mg | 30/day | No | No |
39/02 | Heart infarction | 18 | 7.8 | 1520 | 6.4 | Zuclopethixol 40 mg | Valproate 1,200 mg, Tiapride 300 mg | 0 | No | No |
39/03 | Lung emboly | 32 | 4.9 | 1160 | 6.8 | Clozapine 400 mg | Benperidol 25 mg, Chlorprothixen 150 mg | 0 | No | Yes |
43/03 | Cardio-pulmonary insufficiency | 17 | 6.1 | 1200 | 7.1 | Perazine 300 mg | 0 | No | Yes | |
43/01 | Cardio-pulmonary insufficiency | 16 | 6.1 | 1120 | 6.8 | No | ||||
61/01 | Heart infarction | 16 | 5.7 | 1200 | 6.5 | No | ||||
002/02 | Heart infarction | 7 | 4.7 | 1360 | 7.2 | No | ||||
51/02 | Heart infarction | 24 | 5.5 | 1420 | 6.5 | No | ||||
57/02 | Heart infarction | 18 | 5.5 | 1520 | 7.1 | No | ||||
59/02 | Heart infarction | 13 | 6.6 | 1360 | 6.9 | No | ||||
72/02 | Heart infarction | 24 | 7.8 | 1170 | 6.4 | No | ||||
RZ77 | Electric shock | 24 | 7.6 | 1380 | N.d. | N.d. | ||||
RZ84 | Cardiac arrest | 50 | 6.8 | 1530 | N.d. | Yes | ||||
RZ99 | Cardiac infarction | 14 | 8 | N.d. | N.d. | N.d. |
RNA preparation and microarray experiments
Data analysis
Real-time PCR (qRT-PCR)
Functional annotation
Results
Struct. Gene Down | Gene ID |
p value | FC | Struct. Gene Up | Gene ID |
p value | FC |
---|---|---|---|---|---|---|---|
NM_014979.1 | SV2C | 0.00371605 | −1.70080582 | NM_016239.2 | MYO15A | 0.00379802 | 1.75784335 |
NM_004933.2 | CDH15 | 0.00390321 | −1.40871141 | NM_003763.3 | STX16 | 0.00531162 | 1.18908491 |
NM_021019.2 | MYL6 | 0.00812492 | −1.28310198 | NM_018943.1 | TUBA8 | 0.01092875 | 1.59036875 |
NM_001845.3 | COL4A1 | 0.01033501 | −1.80484582 | NM_025213.1 | SPTBN4 | 0.01339469 | 1.21306121 |
NM_175068.2 | K6IRS3 | 0.01825624 | −1.40542537 | NM_001010925.1 | ANKRD19 | 0.02098038 | 1.42870811 |
NM_033401.2 | CNTNAP4 | 0.02201032 | −1.78975203 | NM_033063.1 | MAP6 | 0.02190119 | 1.23325508 |
NM_205848.1 | SYT6 | 0.02211902 | −1.28653209 | NM_014935.2 | PLEKHA6 | 0.02306862 | 1.35252326 |
NM_003280.1 | TNNC1 | 0.02385658 | −1.65164908 | NM_013231.4 | FLRT2 | 0.02631036 | 1.35458749 |
NM_003764.2 | STX11 | 0.02390039 | −2.13799226 | NM_001856.2 | COL16A1 | 0.02729109 | 1.34794675 |
NM_153649.2 | TPM3 | 0.02617573 | −1.18259359 | NM_080705.2 | TRPV1 | 0.02887878 | 1.25657791 |
NM_024933.2 | FLJ12056 | 0.02716962 | −1.31591072 | NM_145754.2 | KIFC2 | 0.03033599 | 1.24184565 |
NM_006571.2 | DCTN6 | 0.02982324 | −1.18869974 | NM_020405.3 | PLXDC1 | 0.04142866 | 1.23724641 |
NM_177424.1 | STX12 | 0.03003602 | −1.13874539 | NM_145042.2 | MGC16703 | 0.04660599 | 1.45117471 |
NM_002404.1 | MFAP4 | 0.03194134 | −1.50124258 | NM_017514.2 | PLXNA3 | 0.04965694 | 1.23893469 |
NM_032639.2 | PLEKHA8 | 0.03339197 | −1.69703813 | ||||
NM_001855.2 | COL15A1 | 0.03424211 | −1.53571389 | ||||
NM_007350.2 | PHLDA1 | 0.03702036 | −1.38648581 | ||||
NM_152403.2 | FLJ39155 | 0.03760172 | −1.48267611 | ||||
NM_002664.1 | PLEK | 0.03928154 | −1.75702778 | ||||
NM_012335.2 | MYO1F | 0.04072494 | −2.57924603 | ||||
NM_201281.1 | MTMR2 | 0.04809132 | −1.12265023 | ||||
NM_006059.2 | LAMC3 | 0.02377526 | −1.38905428 |
Gene symbol | Gene name |
p value (2) | Gene symbol |
p value (1) | Gene symbol |
p value (pw) |
---|---|---|---|---|---|---|
MTMR2
| Myotubularin-related protein 2 | 0.007121447 |
COL15A1
| 0.007070113 |
STX12
| 0.000514191 |
LAMC3
| Laminin gamma 3 | 0.007877202 |
STX12
| 0.013457459 |
MTMR2
| 0.017657646 |
SYT6
| Synaptotagmin 6 | 0.010554885 |
MTMR2
| 0.014776572 |
SYT6
| 0.018046627 |
COL15A1
| Collagen XV, alpha 1 | 0.010614934 |
SYT6
| 0.018015277 |
DCTN6
| 0.040844042 |
STX12
| Syntaxin 12 | 0.011662093 |
LAMC3
| 0.023460519 |
TPM3
| 0.042311935 |
COL4A1
| Collagen IV, alpha 1 | 0.041537481 |
COL4A1
| 0.039728237 | LAMC3 | 0.062943756 |
MYL6
| Myosin, light chain 6 | 0.050687473 |
MYL6
| 0.04887248 | MFAP4 | 0.068474312 |
PLEK | Pleckstrin | 0.076886961 | PLEK | 0.07730228 | KIFC2 up | 0.085389609 |
CNTNAP4 | Contactin-associated protein 4 | 0.089501846 | MFAP4 | 0.083516435 | TUBA8 up | 0.104664969 |
MFAP4 | Microfibril-associated protein 4 | 0.0901955 | CNTNAP4 | 0.094026743 | FLJ12056 | 0.104863175 |
DCTN6 | Dynactin 6 | 0.092758551 | DCTN6 | 0.105156826 | MGC16703 up | 0.11362909 |
FLJ12056 | Ankyrin repeat domain 53 (ANKRD53) | 0.102586666 | MGC16703 up | 0.105301982 | COL4A1 | 0.156740231 |
TPM3 | Tropomyosin 3, variant 2 | 0.108070257 | TPM3 | 0.106877524 | PLEK | 0.174848002 |
MGC16703 up | Tubulin alpha, pseudo | 0.108094601 | FLJ12056 | 0.217773003 | MYL6 | 0.190495998 |
(2) group-wise two-tailed | (1) group-wise one-tailed | (pw) pair-wise |