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European Archives of Psychiatry and Clinical Neuroscience

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28.09.2018 | Original Paper

Neurobiology of the major psychoses: a translational perspective on brain structure and function—the FOR2107 consortium

verfasst von: Tilo Kircher, Markus Wöhr, Igor Nenadic, Rainer Schwarting, Gerhard Schratt, Judith Alferink, Carsten Culmsee, Holger Garn, Tim Hahn, Bertram Müller-Myhsok, Astrid Dempfle, Maik Hahmann, Andreas Jansen, Petra Pfefferle, Harald Renz, Marcella Rietschel, Stephanie H. Witt, Markus Nöthen, Axel Krug, Udo Dannlowski

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 8/2019

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Abstract

Genetic (G) and environmental (E) factors are involved in the etiology and course of the major psychoses (MP), i.e. major depressive disorder (MDD), bipolar disorder (BD), schizoaffective disorder (SZA) and schizophrenia (SZ). The neurobiological correlates by which these predispositions exert their influence on brain structure, function and course of illness are poorly understood. In the FOR2107 consortium, animal models and humans are investigated. A human cohort of MP patients, healthy subjects at genetic and/or environmental risk, and control subjects (N = 2500) has been established. Participants are followed up after 2 years and twice underwent extensive deep phenotyping (MR imaging, clinical course, neuropsychology, personality, risk/protective factors, biomaterials: blood, stool, urine, hair, saliva). Methods for data reduction, quality assurance for longitudinal MRI data, and (deep) machine learning techniques are employed. In the parallelised animal cluster, genetic risk was introduced by a rodent model (Cacna1c deficiency) and its interactions with environmental risk and protective factors are studied. The animals are deeply phenotyped regarding cognition, emotion, and social function, paralleling the variables assessed in humans. A set of innovative experimental projects connect and integrate data from the human and animal parts, investigating the role of microRNA, neuroplasticity, immune signatures, (epi-)genetics and gene expression. Biomaterial from humans and animals are analyzed in parallel. The FOR2107 consortium will delineate pathophysiological entities with common neurobiological underpinnings (“biotypes”) and pave the way for an etiologic understanding of the MP, potentially leading to their prevention, the prediction of individual disease courses, and novel therapies in the future.

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Titel: Neurobiology of the major psychoses: a translational perspective on brain structure and function—the FOR2107 consortium
verfasst von: Tilo Kircher
Markus Wöhr
Igor Nenadic
Rainer Schwarting
Gerhard Schratt
Judith Alferink
Carsten Culmsee
Holger Garn
Tim Hahn
Bertram Müller-Myhsok
Astrid Dempfle
Maik Hahmann
Andreas Jansen
Petra Pfefferle
Harald Renz
Marcella Rietschel
Stephanie H. Witt
Markus Nöthen
Axel Krug
Udo Dannlowski
Publikationsdatum: 28.09.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 8/2019
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-018-0943-x

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Neurobiology of the major psychoses: a translational perspective on brain structure and function—the FOR2107 consortium

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