Skip to main content
Erschienen in: Lung 1/2012

01.02.2012

Cough Reflex in Lung Transplant Recipients

verfasst von: Alexander G. Duarte, Allen C. Myers

Erschienen in: Lung | Ausgabe 1/2012

Einloggen, um Zugang zu erhalten

Abstract

Lung transplantation has become the standard of care for particular individuals with advanced lung disease. However, this surgical procedure involves interruption of the lower vagal nerve fibers which leads to loss of the protective cough reflex. Injury of the neural pathways involved with the sensory limb of the cough reflex is associated with an increased risk of complications involving the allograft. While loss of the cough reflex was once considered permanent, recent evidence indicates functional and structural restoration is a time-dependent process that occurs 6–12 months after lung transplantation. The implication that the cough reflex may be reestablished in lung transplant recipients provides insight into the dynamic response to airway neural injury that may lead to improvements in allograft tissue repair.
Literatur
1.
Zurück zum Zitat Christie JD, Edwards LB, Aurora P, Dobbels F, Kirk R, Rahmel AO, Stehlik J, Taylor DO, Kucheryavaya AY, Hertz MI (2010) The registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplantation report. J Heart Lung Transpl 29:1104–1118CrossRef Christie JD, Edwards LB, Aurora P, Dobbels F, Kirk R, Rahmel AO, Stehlik J, Taylor DO, Kucheryavaya AY, Hertz MI (2010) The registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplantation report. J Heart Lung Transpl 29:1104–1118CrossRef
2.
3.
Zurück zum Zitat Duarte AG, Lick S (2002) Peri-operative care of the lung transplant patient. Chest Surg Clin N Am 12:397–416PubMedCrossRef Duarte AG, Lick S (2002) Peri-operative care of the lung transplant patient. Chest Surg Clin N Am 12:397–416PubMedCrossRef
4.
Zurück zum Zitat Bloom RD, Goldberg LR, Wang AY, Faust TW, Kotloff RM (2005) An overview of solid organ transplantation. Clin Chest Med 26(4):529–543PubMedCrossRef Bloom RD, Goldberg LR, Wang AY, Faust TW, Kotloff RM (2005) An overview of solid organ transplantation. Clin Chest Med 26(4):529–543PubMedCrossRef
5.
Zurück zum Zitat Studer SM, Levy RD, McNeil K, Orens JB (2004) Lung transplant outcomes: a review of survival, graft function, physiology, health related quality of life and cost effectiveness. Eur Respir J 24:674–685PubMedCrossRef Studer SM, Levy RD, McNeil K, Orens JB (2004) Lung transplant outcomes: a review of survival, graft function, physiology, health related quality of life and cost effectiveness. Eur Respir J 24:674–685PubMedCrossRef
6.
Zurück zum Zitat Larsell O, Mason ML (1921) Experimental degeneration of the vagus nerve and its relationship to the nerve terminations in the lung of the rabbit. J Comp Neurol 33:509–516CrossRef Larsell O, Mason ML (1921) Experimental degeneration of the vagus nerve and its relationship to the nerve terminations in the lung of the rabbit. J Comp Neurol 33:509–516CrossRef
7.
Zurück zum Zitat Higenbottam T, Jackson M, Woolman P, Lowry R, Wallwork J (1989) The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients. Am Rev Respir Dis 140:58–61PubMedCrossRef Higenbottam T, Jackson M, Woolman P, Lowry R, Wallwork J (1989) The cough response to ultrasonically nebulized distilled water in heart-lung transplantation patients. Am Rev Respir Dis 140:58–61PubMedCrossRef
8.
Zurück zum Zitat Hathaway TJ, Higenbottam TW, Morrison JFJ, Clelland CA, Wallwork J (1993) Effects of inhaled capsaicin in heart-lung transplant patients and asthmatic subjects. Am Rev Respir Dis 148:1233–1237PubMed Hathaway TJ, Higenbottam TW, Morrison JFJ, Clelland CA, Wallwork J (1993) Effects of inhaled capsaicin in heart-lung transplant patients and asthmatic subjects. Am Rev Respir Dis 148:1233–1237PubMed
9.
Zurück zum Zitat Brody JS, Klempfner G, Staum MM, Vidyasagar D, Kuhl DE, Wauldhausen JA (1972) Mucociliary clearance after lung denervation and bronchial transection. J Appl Physiol 32:160–164PubMed Brody JS, Klempfner G, Staum MM, Vidyasagar D, Kuhl DE, Wauldhausen JA (1972) Mucociliary clearance after lung denervation and bronchial transection. J Appl Physiol 32:160–164PubMed
10.
Zurück zum Zitat Herve P, Silbert D, Cerrina J, Simonneau G, Dartevelle Pl (1993) Impairment of bronchial mucociliary clearance in long term survivors of heart/lung and double lung transplantation. Chest 103:59–63PubMedCrossRef Herve P, Silbert D, Cerrina J, Simonneau G, Dartevelle Pl (1993) Impairment of bronchial mucociliary clearance in long term survivors of heart/lung and double lung transplantation. Chest 103:59–63PubMedCrossRef
11.
Zurück zum Zitat Laube BL, Karmazyn YJ, Orens JB, Mogayzel PJ (2007) Albuterol improves impaired mucociliary clearance after lung transplantation. J Heart Lung Transpl 26:138–144CrossRef Laube BL, Karmazyn YJ, Orens JB, Mogayzel PJ (2007) Albuterol improves impaired mucociliary clearance after lung transplantation. J Heart Lung Transpl 26:138–144CrossRef
12.
Zurück zum Zitat Iber CP, Simon P, Skatrud JB, Mahowald MW, Dempsey JA (1995) The Breuer-Hering reflex in humans. Effects of pulmonary denervation and hypocapnia. Am J Respir Crit Care Med 152:217–224PubMed Iber CP, Simon P, Skatrud JB, Mahowald MW, Dempsey JA (1995) The Breuer-Hering reflex in humans. Effects of pulmonary denervation and hypocapnia. Am J Respir Crit Care Med 152:217–224PubMed
13.
Zurück zum Zitat Banner NR, Heaton R, Hollingshead L, Guz A, Yacoub MH (1988) Bronchial reactivity to methacholine after combined heart-lung transplantation. Thorax 43:955–959PubMedCrossRef Banner NR, Heaton R, Hollingshead L, Guz A, Yacoub MH (1988) Bronchial reactivity to methacholine after combined heart-lung transplantation. Thorax 43:955–959PubMedCrossRef
14.
Zurück zum Zitat Glanville AR, Theodore J, Baldwin JC, Robin ED (1990) Bronchial responsiveness after human heart-lung transplantation. Chest 97:1360–1366PubMedCrossRef Glanville AR, Theodore J, Baldwin JC, Robin ED (1990) Bronchial responsiveness after human heart-lung transplantation. Chest 97:1360–1366PubMedCrossRef
15.
Zurück zum Zitat Duncan SR, Kagawa FT, Starnes VA, Theodore J (1991) Hypercarbic ventilatory responses of human heart-lung transplant recipients. Am Rev Respir Dis 144:126–130PubMedCrossRef Duncan SR, Kagawa FT, Starnes VA, Theodore J (1991) Hypercarbic ventilatory responses of human heart-lung transplant recipients. Am Rev Respir Dis 144:126–130PubMedCrossRef
16.
Zurück zum Zitat Frost AE, Zamel N, McClean P, Grossman R, Patterson GA, Maurer JR (1992) Hypercapnic ventilatory response in recipients of double lung transplant. Am Rev Respir Dis 146:1610–1612PubMed Frost AE, Zamel N, McClean P, Grossman R, Patterson GA, Maurer JR (1992) Hypercapnic ventilatory response in recipients of double lung transplant. Am Rev Respir Dis 146:1610–1612PubMed
17.
Zurück zum Zitat Bradley GW, Hale T, Pimble J, Rowlandson R, Noble MIM (1982) Effect of vagotomy on the breathing pattern and exercise ability in emphysematous patients. Clin Sci 62:311–319PubMed Bradley GW, Hale T, Pimble J, Rowlandson R, Noble MIM (1982) Effect of vagotomy on the breathing pattern and exercise ability in emphysematous patients. Clin Sci 62:311–319PubMed
18.
Zurück zum Zitat Weill D, Dey GC, Hicks RA, Young KR, Zorn GL, Kirklin JK, Early L, McGiffin DC (2002) A positive donor gram stain does not predict outcome following lung transplantation. J Heart Lung Transpl 21(5):555–558CrossRef Weill D, Dey GC, Hicks RA, Young KR, Zorn GL, Kirklin JK, Early L, McGiffin DC (2002) A positive donor gram stain does not predict outcome following lung transplantation. J Heart Lung Transpl 21(5):555–558CrossRef
19.
Zurück zum Zitat Mattner F, Fischer FS, Weissbrodt H, Chaberny IF, Sohr D, Gottlieb J, Welte T, Henke-Gendo C, Gastmeier P, Strueber M (2007) Post-operative nosocomial infections after lung and heart transplantation. J Heart Lung Transpl 26:241–249CrossRef Mattner F, Fischer FS, Weissbrodt H, Chaberny IF, Sohr D, Gottlieb J, Welte T, Henke-Gendo C, Gastmeier P, Strueber M (2007) Post-operative nosocomial infections after lung and heart transplantation. J Heart Lung Transpl 26:241–249CrossRef
20.
Zurück zum Zitat Aguilar-Guisado M, Givalda J, Ussetti P, Ramos A, Morales P, Blanes M, Bou G, De la Torre-Cisneros R, Roman A, Borro JM, Lama R, Cisneros JM (2007) Pneumonia after lung transplantation in the Resitra cohort: a multicenter prospective study. Am J Transpl 7:1989–1996CrossRef Aguilar-Guisado M, Givalda J, Ussetti P, Ramos A, Morales P, Blanes M, Bou G, De la Torre-Cisneros R, Roman A, Borro JM, Lama R, Cisneros JM (2007) Pneumonia after lung transplantation in the Resitra cohort: a multicenter prospective study. Am J Transpl 7:1989–1996CrossRef
21.
Zurück zum Zitat Valentine VG, Bonvillain RW, Gupta MR, Lombard GA, LaPlace SG, Dhillon GS, Wang G (2008) Infections in lung allografts: ganciclovir era. J Heart Lung Transpl 27:528–535CrossRef Valentine VG, Bonvillain RW, Gupta MR, Lombard GA, LaPlace SG, Dhillon GS, Wang G (2008) Infections in lung allografts: ganciclovir era. J Heart Lung Transpl 27:528–535CrossRef
22.
Zurück zum Zitat Palmer SM, Miralles AP, Howell DN, Brazer SR, Tapson VF, Davis RD (2000) Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest 118:1214–1217PubMedCrossRef Palmer SM, Miralles AP, Howell DN, Brazer SR, Tapson VF, Davis RD (2000) Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest 118:1214–1217PubMedCrossRef
23.
Zurück zum Zitat Robertson AG, Ward C, Pearson JP, Corris PA, Dark JH, Griffin SM (2010) Lung transplantation, gastroesophageal reflux and fundoplication. Ann Thorac Surg 89(2):653–660PubMedCrossRef Robertson AG, Ward C, Pearson JP, Corris PA, Dark JH, Griffin SM (2010) Lung transplantation, gastroesophageal reflux and fundoplication. Ann Thorac Surg 89(2):653–660PubMedCrossRef
24.
Zurück zum Zitat Clifford PS, Bell LB, Hopp FA, Coon RL (1987) Reinnervation of pulmonary stretch receptors. J Appl Physiol 62:1912–1916PubMed Clifford PS, Bell LB, Hopp FA, Coon RL (1987) Reinnervation of pulmonary stretch receptors. J Appl Physiol 62:1912–1916PubMed
25.
Zurück zum Zitat Edmunds LH, Graf D, Nadel JA (1971) Reinnervation of the reimplanted canine lung. J Appl Physiol 31:722–727PubMed Edmunds LH, Graf D, Nadel JA (1971) Reinnervation of the reimplanted canine lung. J Appl Physiol 31:722–727PubMed
26.
Zurück zum Zitat Kawaguchi AT, Shirai M, Yamano M, Ishibashi-Ueda H, Yamatodani A, Kawashima Y (1998) Afferent reinnervation after lung transplantation in the rat. J Heart Lung Transpl 17:341–348 Kawaguchi AT, Shirai M, Yamano M, Ishibashi-Ueda H, Yamatodani A, Kawashima Y (1998) Afferent reinnervation after lung transplantation in the rat. J Heart Lung Transpl 17:341–348
27.
Zurück zum Zitat Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger (2001) Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med 345:731–738PubMedCrossRef Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger (2001) Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med 345:731–738PubMedCrossRef
28.
Zurück zum Zitat Van De Borne P, Neubauer J, Rahnama M, Jansens JL, Montano N, Porta A, Somers VK, Degaute JP (2001) Differential characteristics of neural circulatory control: early versus late after cardiac transplantation. Circulation 104:1809–1813CrossRef Van De Borne P, Neubauer J, Rahnama M, Jansens JL, Montano N, Porta A, Somers VK, Degaute JP (2001) Differential characteristics of neural circulatory control: early versus late after cardiac transplantation. Circulation 104:1809–1813CrossRef
29.
Zurück zum Zitat Butler JE, Anand A, Crawford MR, Glanville AR, McKenzie DK, Paintal AS, Taylor JL, Gandevia SC (2001) Changes in respiratory sensations induced by lobeline after human bilateral lung transplantation. J Physiol 534:583–593PubMedCrossRef Butler JE, Anand A, Crawford MR, Glanville AR, McKenzie DK, Paintal AS, Taylor JL, Gandevia SC (2001) Changes in respiratory sensations induced by lobeline after human bilateral lung transplantation. J Physiol 534:583–593PubMedCrossRef
30.
Zurück zum Zitat De Vito Dabbs A, Hoffman LA, Iacono AT, Zullo TG, McCurry KR, Dauber JH (2004) Are symptom reports useful for differentiating between acute rejection and pulmonary infection after lung transplantation? Heart Lung 33:280–372CrossRef De Vito Dabbs A, Hoffman LA, Iacono AT, Zullo TG, McCurry KR, Dauber JH (2004) Are symptom reports useful for differentiating between acute rejection and pulmonary infection after lung transplantation? Heart Lung 33:280–372CrossRef
31.
Zurück zum Zitat Duarte AG, Terminella L, Smith JT, Campbell GA, Myers AC, Lick S (2008) Recovery of cough in lung transplant recipients. Chest 134:310–316PubMedCrossRef Duarte AG, Terminella L, Smith JT, Campbell GA, Myers AC, Lick S (2008) Recovery of cough in lung transplant recipients. Chest 134:310–316PubMedCrossRef
32.
Zurück zum Zitat Kusindarta DL, Atoji Y, Yamamoto Y (2004) Nerve plexuses in the trachea and extrapulmonary bronchi of the rat. Arch Histol Cytol 67:41–55PubMedCrossRef Kusindarta DL, Atoji Y, Yamamoto Y (2004) Nerve plexuses in the trachea and extrapulmonary bronchi of the rat. Arch Histol Cytol 67:41–55PubMedCrossRef
33.
Zurück zum Zitat Lamb JP, Sparrow MP (2002) Three dimensional mapping of sensory innervation with substance P in porcine bronchial mucosa-comparison with human airways. Am J Respir Crit Care Med 166:1269–1281PubMedCrossRef Lamb JP, Sparrow MP (2002) Three dimensional mapping of sensory innervation with substance P in porcine bronchial mucosa-comparison with human airways. Am J Respir Crit Care Med 166:1269–1281PubMedCrossRef
34.
Zurück zum Zitat Canning BJ, Mori N, Mazzone SB (2006) Vagal afferent nerves regulating the cough reflex. Respir Physiol Neurobiol 152:223–242PubMedCrossRef Canning BJ, Mori N, Mazzone SB (2006) Vagal afferent nerves regulating the cough reflex. Respir Physiol Neurobiol 152:223–242PubMedCrossRef
35.
Zurück zum Zitat Groneberg DA, Niimi A, Dinh T, Cosio B, Hew M, Fischer A, Chung KF (2004) Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 170:1276–1280PubMedCrossRef Groneberg DA, Niimi A, Dinh T, Cosio B, Hew M, Fischer A, Chung KF (2004) Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 170:1276–1280PubMedCrossRef
36.
Zurück zum Zitat Lin YS, Lin R-L, Bien M-Y, Ho C-Y, Kou YR (2009) Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors. J Appl Physiol 106:1142–1152PubMedCrossRef Lin YS, Lin R-L, Bien M-Y, Ho C-Y, Kou YR (2009) Sensitization of capsaicin-sensitive lung vagal afferents by anandamide in rats: role of transient receptor potential vanilloid 1 receptors. J Appl Physiol 106:1142–1152PubMedCrossRef
37.
Zurück zum Zitat Buvry A, Yang YR, Tavakoli R, Frossard N (1999) Calcitonin gene related protein immunoreactive nerves and neuroendocrine cells after lung transplantation in the rat. Am J Respir Cell Mol Biol 20:1268–1273PubMed Buvry A, Yang YR, Tavakoli R, Frossard N (1999) Calcitonin gene related protein immunoreactive nerves and neuroendocrine cells after lung transplantation in the rat. Am J Respir Cell Mol Biol 20:1268–1273PubMed
38.
Zurück zum Zitat Springall DR, Polak JM, Howard L, Power RF, Krausz T, Manickam S, Banner NR, Khagani A, Rose M, Yacoub MH (1990) Persistence of intrinsic neurons and possible phenotypic changes after extrinsic denervation of human respiratory tract by heart-lung transplantation. Am Rev Respir Dis 141:1538–1546PubMed Springall DR, Polak JM, Howard L, Power RF, Krausz T, Manickam S, Banner NR, Khagani A, Rose M, Yacoub MH (1990) Persistence of intrinsic neurons and possible phenotypic changes after extrinsic denervation of human respiratory tract by heart-lung transplantation. Am Rev Respir Dis 141:1538–1546PubMed
Metadaten
Titel
Cough Reflex in Lung Transplant Recipients
verfasst von
Alexander G. Duarte
Allen C. Myers
Publikationsdatum
01.02.2012
Verlag
Springer-Verlag
Erschienen in
Lung / Ausgabe 1/2012
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-011-9352-x

Weitere Artikel der Ausgabe 1/2012

Lung 1/2012 Zur Ausgabe

EditorialNotes

Editorial

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.