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Erschienen in:

01.02.2013

Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

verfasst von: Monique Engel, Relana M. E. Nowacki, Lucy K. Reiss, Stefan Uhlig, Coen H. M. P. Willems, Nico Kloosterboer, J. Freek van Iwaarden, Alide C. P. Sewing, Matthias Seehase, Verena A. C. Lambermont, Jennifer J. P. Collins, Luc J. I. Zimmermann, Gijs D. Vos, Boris W. Kramer

Erschienen in: Lung | Ausgabe 1/2013

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Abstract

Background

Recruitment manoeuvres are widely used in clinical practice to open the lung and prevent lung injury by derecruitment, although the evidence is still discussed. In this study two different recruitment manoeuvres were compared to no recruitment manoeuvres (control) in ventilated sheep with acute respiratory distress syndrome (ARDS), induced by lung lavage.

Methods

We performed a prospective, randomised study in 26 ventilated sheep with ARDS, to evaluate the effect of two different recruitment manoeuvres on gas exchange, blood pressure and lung injury. The two different recruitment manoeuvres, the high pressure recruitment manoeuvre (HPRM), with high peak pressure, and the smooth and moderate recruitment manoeuvre (SMRM), with lower peak pressure, were compared to controls (no recruitment) after disconnection. Oxygenation index and ventilation efficacy index were calculated to evaluate gas exchange. Lung injury was assessed by inflammatory response in broncho-alveolar lavage fluid (BALF) and blood and histology of the lung.

Results

Oxygenation index improved significantly after both recruitment manoeuvres compared with controls, but no significant difference was found between the recruitment manoeuvres. Blood pressure decreased after HPRM but not after SMRM. HPRM induced a higher number of total cells and more neutrophils in the BALF. In the histology of the lung, mean alveolar size was increased in the dorsocranial region of the lung of SMRM compared to controls.

Conclusion

Recruitment manoeuvres improved oxygenation, but SMRM was superior, with respect to hemodynamics and pulmonary inflammation, in ventilated sheep suffering from ARDS induced by lung lavage.

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Titel: Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome
verfasst von: Monique Engel
Relana M. E. Nowacki
Lucy K. Reiss
Stefan Uhlig
Coen H. M. P. Willems
Nico Kloosterboer
J. Freek van Iwaarden
Alide C. P. Sewing
Matthias Seehase
Verena A. C. Lambermont
Jennifer J. P. Collins
Luc J. I. Zimmermann
Gijs D. Vos
Boris W. Kramer
Publikationsdatum: 01.02.2013
Verlag: Springer-Verlag
Erschienen in: Lung / Ausgabe 1/2013
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-012-9428-2

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Comparison of Recruitment Manoeuvres in Ventilated Sheep with Acute Respiratory Distress Syndrome

Abstract

Background

Methods

Results

Conclusion

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Parodontalbehandlung verbessert Prognose bei Katheterablation

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Background

Methods

Results

Conclusion

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