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01.10.2015

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence

verfasst von: Eric Wirtschafter, Ann E. Walts, Sandy T. Liu, Alberto M. Marchevsky

Erschienen in: Lung | Ausgabe 5/2015

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Abstract

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease course in 169 additional patients. Some patients presented with one or more carcinoid tumors associated with multiple small pulmonary nodules on imaging studies and showed DIPNECH as a somewhat unexpected pathologic finding. Others presented with multiple small pulmonary nodules that raised suspicion of metastatic disease on imaging. A third subset was presented with previously unexplained respiratory symptoms. In most patients, DIPNECH was associated with a good prognosis, with chronological progression into a subsequent carcinoid tumor noted in only one patient and death attributed directly to DIPNECH in only two patients. There is no best evidence to support the use of octreotide, steroids, or bronchodilators in DIPNECH patients.

Champaneria MC, Modlin IM, Kidd M et al (2006) Friedrich Feyrter: a precise intellect in a diffuse system. Neuroendocrinology 83(5–6):394–404CrossRefPubMed

Gosney JR, Sissons MCJ, Allibone RO (1988) Neuroendocrine cell populations in normal human lungs: a quantitative study. Thorax 43(11):878–882PubMedCentralCrossRefPubMed

Sunday ME, Hua J, Dai HB et al (1990) Bombesin increases fetal lung growth and maturation in utero and in organ culture. Am J Respir Cell Mol Biol 3(3):199–205CrossRefPubMed

Wharton J, Polak JM, Bloom SR et al (1978) Bombesin-like immunoreactivity in the lung. Nature 273(5665):769–770CrossRefPubMed

Alshehri M, Cutz E, Banzhoff A et al (1997) Hyperplasia of pulmonary neuroendocrine cells in a case of childhood pulmonary emphysema. Chest 112(2):553–556CrossRefPubMed

Yeger H, Speirs V, Youngson C et al (1996) Pulmonary neuroendocrine cell in cultures of human infant airway mucosa from postmortem tissues. Am J Respir Cell Mol Biol 15(2):232–236CrossRefPubMed

Benson REC, Rosado-de-Christenson ML, Martinez-Jimenez S et al (2013) Spectrum of pulmonary neuroendocrine proliferations and neoplasms. Radiographics 33(6):1631–1649CrossRefPubMed

Gosney JR (2004) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia as a precursor to pulmonary neuroendocrine tumors. Chest 125(5 Suppl):108SCrossRefPubMed

Miller MA, Mark GJ, Kanarek D (1978) Multiple peripheral pulmonary carcinoids and tumorlets of carcinoid type, with restrictive and obstructive lung disease. Am J Med 65(2):373–378CrossRefPubMed

10.

Aguayo SM, Miller YE, Waldron JA Jr et al (1992) Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. New Engl J Med 327(18):1285–1288CrossRefPubMed

11.

Travis W, Nicholson A, Marx A (eds) (2015) Tumors of the lung, pleura thymus and heart. IARC Press, Lyon

12.

Marchevsky AM, Wirtschafter E, Walts AE (2015) The spectrum of changes in adults with multifocal pulmonary neuroendocrine proliferations: what is the minimum set of pathologic criteria to diagnose DIPNECH? Hum Pathol 46(2):176–181CrossRefPubMed

13.

Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Version 5.1.0. Updated March 2011. Available at: http://handbook.cochrane.org. Accessed February 19, 2015

14.

Davies SJ, Gosney JR, Hansell DM et al (2007) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. Thorax 62(3):248–252PubMedCentralCrossRefPubMed

15.

Al-Ayoubi AM, Ralston JS, Richardson SR et al (2014) Diffuse pulmonary neuroendocrine cell hyperplasia involving the chest wall. Ann Thorac Surg 97(1):333–335CrossRefPubMed

16.

Aubry MC, Thomas CF Jr, Jett JR et al (2007) Significance of multiple carcinoid tumors and tumorlets in surgical lung specimens: analysis of 28 patients. Chest 131(6):1635–1643CrossRefPubMed

17.

Carmichael MG, Zacher LL (2005) The demonstration of pulmonary neuroendocrine cell hyperplasia with tumorlets in a patient with chronic cough and a history of multiple medical problems. Mil Med 170(5):439–441CrossRefPubMed

18.

Carr LL, Chung JH, Achcar RD et al (2015) The clinical course of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. Chest 147(2):415–422CrossRefPubMed

19.

Cohen AJ, King TE Jr, Gilman LB et al (1998) High expression neutral endopeptidase in idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells. Am J Respir Crit Care Med 158(5.1):1593–1599CrossRefPubMed

20.

Gorshtein A, Gross DJ, Barak D et al (2012) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors: clinical experience with a rare entity. Cancer 118(3):612–619CrossRefPubMed

21.

Lim C, Stanford D, Young I et al (2010) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a report of two cases. Pathol Int 60(7):538–541CrossRefPubMed

22.

Miller RR, Muller NL (1995) Neuroendocrine cell hyperplasia and obliterative bronchiolitis in patients with peripheral carcinoid tumors. Am J Surg Pathol 19(6):653–658CrossRefPubMed

23.

Walker CM, Vummidi D, Benditt JO et al (2012) What is DIPNECH? Clin Imaging 36(5):647–649CrossRefPubMed

24.

Warth A, Herpel E, Schmahl A et al (2008) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) in association with an adenocarcinoma: a case report. J Med Case Rep 2:21PubMedCentralCrossRefPubMed

25.

Canessa PA, Santini D, Zanelli M et al (1997) Pulmonary tumorlets and microcarcinoids in bronchiectasis. Monaldi Arch Chest Dis 52(2):138–139PubMed

26.

Dwarakanath A, Kumar A (2013) A puzzling lady with persistent wheezing and pulmonary nodules. N Z Med J 126(1378):82–85PubMed

27.

McGuire AL, Maziak DE, Sekhon HS (2013) Diffuse intrapulmonary neuroendocrine cell hyperplasia. Can Respir J 20(6):406–408PubMedCentralPubMed

28.

Stenzinger A, Weichert W, Hensel M et al (2010) Incidental postmortem diagnosis of DIPNECH in a patient with previously unexplained ‘asthma bronchiale’. Pathol Res Pract 206(11):785–787CrossRefPubMed

29.

Tippett VM, Wathen CG (2010) Diffuse idiopathic neuroendocrine cell hyperplasia: an unusual cause of breathlessness and pulmonary nodules. BMJ Case Rep. doi:10.1136/bcr.05.2010.3006 PubMedCentralPubMed

30.

Zhou H, Ge Y, Janssen B, 4 et al (2014) Double lung transplantation for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. J Bronchology Interv Pulmonol 21:342–345CrossRefPubMed

31.

Falkenstern-Ge RF, Kimmich M, Friedel G et al (2011) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: 7-year follow-up of a rare clinicopathologic syndrome. J Cancer Res Clin Oncol 137(10):1495–1498CrossRefPubMed

32.

Nassar AA, Jaroszewski DE, Helmers RA et al (2011) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a systematic overview. Am J Respir Crit Care Med 184(1):8–16CrossRefPubMed

33.

Armas OA, White DA, Erlandson RA et al (1995) Diffuse idiopathic pulmonary neuroendocrine cell proliferation presenting as interstitial lung disease. Am J Surg Pathol 19(18):963–970CrossRefPubMed

34.

Irshad S, McLean E, Rankin S et al (2010) Unilateral diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and multiple carcinoids treated with surgical resection. J Thorac Oncol 5(6):921–923CrossRefPubMed

35.

Montoro Zulueta FJ, Martinez Prieto M, Verdugo Cartas MI et al (2012) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with multiple synchronous carcinoid tumors. Arch Bronchoneumol 48(12):472–475

36.

Oba H, Nishida K, Takeuchi S et al (2013) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with a central and peripheral carcinoid and multiple tumorlets: a case report emphasizing the role of neuropeptide hormones and human gonadotropin-alpha. Endocr Pathol 24(4):220–228CrossRefPubMed

37.

Adams H, Brack T, Kestenholz P et al (2006) Diffuse idiopathic neuroendocrine cell hyperplasia causing severe airway obstruction in a patient with a carcinoid tumor. Respiration 73(5):690–693CrossRefPubMed

38.

Cameron CM, Roberts F, Connell J et al (2011) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an unusual case of cyclical ectopic adrenocorticotrophic syndrome. Br J Radiol 84(997):e14–e17CrossRefPubMed

39.

Coletta EN, Voss LR, Lima MS et al (2009) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia accompanied by airflow obstruction. J Bras Pneumol 35(5):489–494CrossRefPubMed

40.

Johney EC, Pfannschmidt J, Rieker RJ et al (2006) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and a typical carcinoid tumor. J Thorac Cardiovasc Surg 131(5):1207–1208CrossRefPubMed

41.

Ruffini E, Bongiovanni M, Cavallo A et al (2004) The significance of associated pre-invasive lesions in patients resected for primary lung neoplasms. Eur J Cardiothorac Surg 26(1):165–172CrossRefPubMed

42.

Rowan C, Hansell DM, Renzoni E et al (2012) Diffuse cystic lung disease of unexplained cause with coexistent small airway disease: a possible causal relationship? Am J Surg Pathol 36(2):228–234CrossRefPubMed

43.

Anevlavis S, Cancellieri A, Livi V et al (2012) A 66-year-old woman with dry cough and exertional dyspnea. Chest 142(3):802–805CrossRefPubMed

44.

Dvorackova J, Macak J, Buzrla P (2013) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: case report and review of literature. Cesk Patol 49(2):99–102PubMed

45.

Fessler MB, Cool CD, Miller YE et al (2004) Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells in a patient with acromegaly. Respirology 9(2):274–277CrossRefPubMed

46.

Killen H (2014) DIPNECH presenting on a background of malignant melanoma: new lung nodules are not always what they seem. BMJ Case Rep. doi:10.1136/bcr-2014-203667

47.

Lee JS, Brown KK, Cool C et al (2002) Diffuse pulmonary neuroendocrine cell hyperplasia: radiologic and clinical features. J Comput Assist Tomogr 26(2):180–184CrossRefPubMed

48.

Patel C, Tirukonda P, Bishop R et al (2012) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) masquerading as metastatic carcinoma with multiple pulmonary deposits. Clin Imaging 36(6):833–836CrossRefPubMed

49.

Reyes LJ, Majó J, Perich D et al (2007) Neuroendocrine cell hyperplasia as an unusual form of interstitial lung disease. Respir Med 101(8):1840–1843CrossRefPubMed

50.

Mireskandari M, Abdirad A, Zhang Q et al (2013) Association of small foci of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) with adenocarcinoma of the lung. Pathol Res Prac 209(9):578–584CrossRef

51.

Gosney JR, Williams IJ, Dodson AR et al (2011) Morphology and antigen expression profile of pulmonary neuroendocrine cells in reactive proliferations and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). Histopathology 59(4):751–762CrossRefPubMed

Titel: Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence
verfasst von: Eric Wirtschafter
Ann E. Walts
Sandy T. Liu
Alberto M. Marchevsky
Publikationsdatum: 01.10.2015
Verlag: Springer US
Erschienen in: Lung / Ausgabe 5/2015
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-015-9755-1

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