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International Journal of Legal Medicine

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01.03.2007 | Original Article

Haplotypes and mutation analysis of 22 Y-chromosomal STRs in Korean father–son pairs

verfasst von: Hwan Young Lee, Myung Jin Park, Ukhee Chung, Han Young Lee, Woo Ick Yang, Sang-Ho Cho, Kyoung-Jin Shin

Erschienen in: International Journal of Legal Medicine | Ausgabe 2/2007

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Abstract

We analyzed 369 Korean father/son haplotype transfers in 355 families at 22 Y-STRs (DYS19, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS388, DYS437, DYS438, DYS439, DYS446, DYS447, DYS448, DYS449, DYS456, DYS458, DYS464, DYS635, and GATA H4.1). A total of 350 haplotypes were observed with an overall haplotype diversity of 0.9999. Among these, 345 were unique and five were found twice. Furthermore, 36 mutations were identified, giving locus-specific mutation rate estimates between 0.0 and 19.0 × 10⁻³ per generation and an average mutation rate estimate of 3.9 × 10⁻³ (95% CI 2.7–5.4 × 10⁻³). The compilation of Y-STR mutation events for the present study and previous studies demonstrates that DYS449, DYS458, DYS635, DYS456 and DYS439 are the most prone to mutations and that their overall average mutation rate estimate is 2.36 × 10^–3 (95% CI 2.03–2.73 × 10^–33).

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Titel: Haplotypes and mutation analysis of 22 Y-chromosomal STRs in Korean father–son pairs
verfasst von: Hwan Young Lee
Myung Jin Park
Ukhee Chung
Han Young Lee
Woo Ick Yang
Sang-Ho Cho
Kyoung-Jin Shin
Publikationsdatum: 01.03.2007
Verlag: Springer-Verlag
Erschienen in: International Journal of Legal Medicine / Ausgabe 2/2007
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI: https://doi.org/10.1007/s00414-006-0130-x

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