Skip to main content
Erschienen in: Journal of Neurology 12/2010

01.12.2010 | Original Communication

Right hemisphere dysfunction and emotional processing in ALS: an fMRI study

verfasst von: A. Palmieri, M. Naccarato, S. Abrahams, M. Bonato, C. D’Ascenzo, S. Balestreri, V. Cima, G. Querin, R. Dal Borgo, L. Barachino, C. Volpato, C. Semenza, E. Pegoraro, C. Angelini, G. Sorarù

Erschienen in: Journal of Neurology | Ausgabe 12/2010

Einloggen, um Zugang zu erhalten

Abstract

Emotional processing may be abnormal in amyotrophic lateral sclerosis (ALS). Our aim was to explore functional anatomical correlates in the processing of aversive information in ALS patients. We examined the performance of nine non-demented ALS patients and 10 healthy controls on two functional MRI (fMRI) tasks, consisting of an emotional attribution task and a memory recognition task of unpleasant versus neutral stimuli. During the emotional decision task, subjects were asked to select one of three unpleasant or neutral words. During the memory task, subjects were asked to recognize words presented during the previous task. Controls showed, as expected, greater activation in the right middle frontal gyrus during selection of unpleasant than neutral words, and a greater activation mainly in right-sided cerebral areas during the emotional recognition task. Conversely, patients showed a general increase in activation of the left hemisphere, and reduced activation in right hemisphere in both emotional tasks. Such findings may suggest extra-motor neurodegeneration involving key circuits of emotions, mostly negative, commonly involved in FTD.
Literatur
1.
Zurück zum Zitat Kew JJ, Goldstein LH, Leigh PN, Abrahams S, Cosgrave N, Passingham RE, Frackowiak RS, Brooks DJ (1993) The relationship between abnormalities of cognitive function and cerebral activation in amyotrophic lateral sclerosis. A neuropsychological and positron emission tomography study. Brain 116:1399–1423CrossRefPubMed Kew JJ, Goldstein LH, Leigh PN, Abrahams S, Cosgrave N, Passingham RE, Frackowiak RS, Brooks DJ (1993) The relationship between abnormalities of cognitive function and cerebral activation in amyotrophic lateral sclerosis. A neuropsychological and positron emission tomography study. Brain 116:1399–1423CrossRefPubMed
2.
Zurück zum Zitat Abrahams S, Goldstein LH, Kew JJ, Brooks DJ, Lloyd CM, Frith CD, Leigh PN (1996) Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET study. Brain 119:2105–2120CrossRefPubMed Abrahams S, Goldstein LH, Kew JJ, Brooks DJ, Lloyd CM, Frith CD, Leigh PN (1996) Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET study. Brain 119:2105–2120CrossRefPubMed
3.
Zurück zum Zitat Abrahams S, Goldstein LH, Simmons A, Brammer M, Williams SC, Giampietro V, Leigh PN (2004) Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain 127:1507–1517CrossRefPubMed Abrahams S, Goldstein LH, Simmons A, Brammer M, Williams SC, Giampietro V, Leigh PN (2004) Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain 127:1507–1517CrossRefPubMed
4.
Zurück zum Zitat Mezzapesa DM, Ceccarelli A, Dicuonzo F, Carella A, De Caro MF, Lopez M, Samarelli V, Livrea P, Simone IL (2007) Whole-Brain and regional brain atrophy in Amyotrophic Lateral Sclerosis. Am J Neuroradiol 28:255–259CrossRefPubMed Mezzapesa DM, Ceccarelli A, Dicuonzo F, Carella A, De Caro MF, Lopez M, Samarelli V, Livrea P, Simone IL (2007) Whole-Brain and regional brain atrophy in Amyotrophic Lateral Sclerosis. Am J Neuroradiol 28:255–259CrossRefPubMed
5.
Zurück zum Zitat Abrahams S, Goldstein LH, Suckling J, Ng V, Simmons A, Chitnis X, Atkins L, Williams SC, Leigh PN (2005) Frontotemporal white matter changes in amyotrophic lateral sclerosis. J Neurol 252:321–331CrossRefPubMed Abrahams S, Goldstein LH, Suckling J, Ng V, Simmons A, Chitnis X, Atkins L, Williams SC, Leigh PN (2005) Frontotemporal white matter changes in amyotrophic lateral sclerosis. J Neurol 252:321–331CrossRefPubMed
6.
Zurück zum Zitat Abrahams S, Leigh PN, Goldstein LH (2005) Cognitive change in ALS: a prospective study. Neurology 64:1222–1226PubMed Abrahams S, Leigh PN, Goldstein LH (2005) Cognitive change in ALS: a prospective study. Neurology 64:1222–1226PubMed
7.
Zurück zum Zitat Phukan J, Pender NP, Hardiman O (2007) Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol 6:944–1003CrossRef Phukan J, Pender NP, Hardiman O (2007) Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol 6:944–1003CrossRef
8.
Zurück zum Zitat Abrahams S, Goldstein LH, Al-Chalabi A, Pickering A, Morris RG, Passingham RE, Brooks DJ, Leigh PN (1997) Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 62:464–472CrossRefPubMed Abrahams S, Goldstein LH, Al-Chalabi A, Pickering A, Morris RG, Passingham RE, Brooks DJ, Leigh PN (1997) Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 62:464–472CrossRefPubMed
9.
Zurück zum Zitat Abrahams S, Leigh PN, Harvey A, Vythelingum GN, Grisé D, Goldstein LH (2000) Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia 38:734–747CrossRefPubMed Abrahams S, Leigh PN, Harvey A, Vythelingum GN, Grisé D, Goldstein LH (2000) Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS). Neuropsychologia 38:734–747CrossRefPubMed
10.
Zurück zum Zitat Grossaman A, Wooley-Levine S, Bradley W, Milller R (2007) Detecting neurobehavioral changes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 8:56–61CrossRef Grossaman A, Wooley-Levine S, Bradley W, Milller R (2007) Detecting neurobehavioral changes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 8:56–61CrossRef
11.
Zurück zum Zitat Flaherty-Craig CV, Simmons Z (2004) Deficient social judgement in non-bulbar amyotrophic lateral sclerosis. Neurology 62:323–324 Flaherty-Craig CV, Simmons Z (2004) Deficient social judgement in non-bulbar amyotrophic lateral sclerosis. Neurology 62:323–324
12.
Zurück zum Zitat Gibbons ZC, Richardson A, Neary D, Snowden JS (2008) Behaviour in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9:67–74CrossRefPubMed Gibbons ZC, Richardson A, Neary D, Snowden JS (2008) Behaviour in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9:67–74CrossRefPubMed
13.
Zurück zum Zitat Palmieri A, Abrahams S, Sorarù G, Mattiuzzi L, D’Ascenzo C, Pegoraro E, Angelini C (2009) Emotional Lability in MND: relationship to cognition and psychopathology and impact on caregivers. J Neurol Sci 278:16–20CrossRefPubMed Palmieri A, Abrahams S, Sorarù G, Mattiuzzi L, D’Ascenzo C, Pegoraro E, Angelini C (2009) Emotional Lability in MND: relationship to cognition and psychopathology and impact on caregivers. J Neurol Sci 278:16–20CrossRefPubMed
14.
Zurück zum Zitat Zimmerman EK, Eslinger PIJ, Simmons Z, Barrett AM (2007) Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol 20:79–82CrossRefPubMed Zimmerman EK, Eslinger PIJ, Simmons Z, Barrett AM (2007) Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol 20:79–82CrossRefPubMed
15.
Zurück zum Zitat Snowden JS, Austin NA, Sembi S, Thompson JC, Craufurd D, Neary D (2008) Emotion recognition in Huntington’s disease and frontotemporal dementia. Neuropsychologia 46:2638–2649CrossRefPubMed Snowden JS, Austin NA, Sembi S, Thompson JC, Craufurd D, Neary D (2008) Emotion recognition in Huntington’s disease and frontotemporal dementia. Neuropsychologia 46:2638–2649CrossRefPubMed
16.
Zurück zum Zitat Papps B, Abrahams S, Wicks P, Leigh PN, Goldstein LH (2005) Changes in memory for emotional material in amyotrophic lateral sclerosis. Neuropsychologia 43:1107–1114CrossRefPubMed Papps B, Abrahams S, Wicks P, Leigh PN, Goldstein LH (2005) Changes in memory for emotional material in amyotrophic lateral sclerosis. Neuropsychologia 43:1107–1114CrossRefPubMed
17.
Zurück zum Zitat Lulé D, Kurt A, Jurgens R, Kassubek J, Diekmann V, Kraft E, Neumann N, Ludolph AC, Birbaumer N, Anders S (2005) Emotional responding in amyotrophic lateral sclerosis. J Neurol 252:1517–1524CrossRefPubMed Lulé D, Kurt A, Jurgens R, Kassubek J, Diekmann V, Kraft E, Neumann N, Ludolph AC, Birbaumer N, Anders S (2005) Emotional responding in amyotrophic lateral sclerosis. J Neurol 252:1517–1524CrossRefPubMed
18.
Zurück zum Zitat Lulé D, Diekmann V, Anders S, Kassubek J, Kübler A, Ludolph AC, Birbaumer N (2007) Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS). J Neurol 254:519–527CrossRefPubMed Lulé D, Diekmann V, Anders S, Kassubek J, Kübler A, Ludolph AC, Birbaumer N (2007) Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS). J Neurol 254:519–527CrossRefPubMed
19.
Zurück zum Zitat Brooks BR, Miller RG, Swash M, Munsat TL (2000) EL Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. World Federation of Neurology Research Group on Motor Neuron Disease. Amyotroph Lateral Scler Other Motor Disord 1:293–299CrossRef Brooks BR, Miller RG, Swash M, Munsat TL (2000) EL Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. World Federation of Neurology Research Group on Motor Neuron Disease. Amyotroph Lateral Scler Other Motor Disord 1:293–299CrossRef
20.
Zurück zum Zitat Cederbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A (1999) BDNF ALS study group (Phase III). The ALSFRS-R: a revised als functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 169:13–21CrossRef Cederbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A (1999) BDNF ALS study group (Phase III). The ALSFRS-R: a revised als functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 169:13–21CrossRef
21.
Zurück zum Zitat Beck Depression Inventory manual. 2nd edn. San Antonio: Psychological Corporation (1996). (Italian version: Manuale. Ghisi M, Flebus GB, Montano A, Sanavio E, Sica Firenze C: O. S.,2006) Beck Depression Inventory manual. 2nd edn. San Antonio: Psychological Corporation (1996). (Italian version: Manuale. Ghisi M, Flebus GB, Montano A, Sanavio E, Sica Firenze C: O. S.,2006)
22.
Zurück zum Zitat Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF (1998) Frontototemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51:1546–1554PubMed Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF (1998) Frontototemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51:1546–1554PubMed
23.
Zurück zum Zitat Williams SM (1986) Factor analyses of the Edinburgh handedness Inventory. Cortex 22:325–326PubMed Williams SM (1986) Factor analyses of the Edinburgh handedness Inventory. Cortex 22:325–326PubMed
24.
Zurück zum Zitat Folstein MF, Folstein SE, McHugh PR (1975) Mini Mental State: a practical method for grading the cognitive state of patiens for the clinician. J Psychiatr Res 12:189–190CrossRefPubMed Folstein MF, Folstein SE, McHugh PR (1975) Mini Mental State: a practical method for grading the cognitive state of patiens for the clinician. J Psychiatr Res 12:189–190CrossRefPubMed
25.
Zurück zum Zitat Sartori G, Colombo L, Vallar G, Rusconi M L, Pinarello A (1997) T.I.B. Test di intelligenza breve per la valutazione del quoziente intellettivo attuale e pre-morboso. Giornale dell’ordine Nazionale Degli Psicologi Sartori G, Colombo L, Vallar G, Rusconi M L, Pinarello A (1997) T.I.B. Test di intelligenza breve per la valutazione del quoziente intellettivo attuale e pre-morboso. Giornale dell’ordine Nazionale Degli Psicologi
26.
Zurück zum Zitat Raven JC (1965) RCPM: guide to using the coloured progressive matrices. Psychological Corp, New York Raven JC (1965) RCPM: guide to using the coloured progressive matrices. Psychological Corp, New York
27.
Zurück zum Zitat Spinnler H, Tognoni G (1987) Standardizzazione taratura italiana dei test neuropsicologici. Italian J Neurol Sci 8(Suppl):1–120 Spinnler H, Tognoni G (1987) Standardizzazione taratura italiana dei test neuropsicologici. Italian J Neurol Sci 8(Suppl):1–120
28.
Zurück zum Zitat Nelson HE (1976) Modified Card Sorting Test. Firenze, Italy: O.S., Firenze (2003) Nelson HE (1976) Modified Card Sorting Test. Firenze, Italy: O.S., Firenze (2003)
29.
Zurück zum Zitat Reitan RM (1998) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 8:271–276CrossRef Reitan RM (1998) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 8:271–276CrossRef
30.
Zurück zum Zitat Sánchez-Cubillo I, Periáñez JA, Adrover-Roig D, Rodríguez-Sánchez JM, Ríos-Lago M, Tirapu J, Barceló F (2009) Construct validity of the Trail Making Test: role of task-switching, working memory, inhibition/interference control, and visuomotor abilities. J Int Neuropsychol Soc 15:438–450CrossRefPubMed Sánchez-Cubillo I, Periáñez JA, Adrover-Roig D, Rodríguez-Sánchez JM, Ríos-Lago M, Tirapu J, Barceló F (2009) Construct validity of the Trail Making Test: role of task-switching, working memory, inhibition/interference control, and visuomotor abilities. J Int Neuropsychol Soc 15:438–450CrossRefPubMed
31.
Zurück zum Zitat Wechsler D (1998) Wechsler Adult Intelligence Scale Revised (WAIS-R). Versione Italiana a cura di Laicardi e Orsini. O.S., Firenze, Firenze, Italy Wechsler D (1998) Wechsler Adult Intelligence Scale Revised (WAIS-R). Versione Italiana a cura di Laicardi e Orsini. O.S., Firenze, Firenze, Italy
32.
Zurück zum Zitat Warrington EK (1984) Recognition memory test. NFER-Nelson, Windsor Warrington EK (1984) Recognition memory test. NFER-Nelson, Windsor
33.
Zurück zum Zitat Kaplan EF, Goodglass H, Weintraub S (1983) The Boston Naming Test: The experimental edition. Boston: Kapan and Gooodglass (2nd edn Philadelphia: Lea & Fabiger) Kaplan EF, Goodglass H, Weintraub S (1983) The Boston Naming Test: The experimental edition. Boston: Kapan and Gooodglass (2nd edn Philadelphia: Lea & Fabiger)
34.
Zurück zum Zitat Osterrieth PA (1944) Le test de copie d’une figure complex: contribution a l’etude de la perception et de la memoire. Arch Psichol 30:286–356 Osterrieth PA (1944) Le test de copie d’une figure complex: contribution a l’etude de la perception et de la memoire. Arch Psichol 30:286–356
35.
Zurück zum Zitat Tabert MH, Borod JC, Tang CY, Lange G, Wei TC, Johnson R, Nusbaum AO, Buchsbaum MS (2001) Differential amygdala activation during emotional decision and recognition memory tasks using unpleasent words: an fMRI study. Neuropsychologia 39:556–573CrossRefPubMed Tabert MH, Borod JC, Tang CY, Lange G, Wei TC, Johnson R, Nusbaum AO, Buchsbaum MS (2001) Differential amygdala activation during emotional decision and recognition memory tasks using unpleasent words: an fMRI study. Neuropsychologia 39:556–573CrossRefPubMed
36.
Zurück zum Zitat Spielberger CD, Gursuch RL, Lushene RE (1989) State-Trait Anxiety Inventory-Y Form. Italian Edition by Pedrabissi L and Santinello M. Firenze, Italy: O.S., Firenze Spielberger CD, Gursuch RL, Lushene RE (1989) State-Trait Anxiety Inventory-Y Form. Italian Edition by Pedrabissi L and Santinello M. Firenze, Italy: O.S., Firenze
37.
Zurück zum Zitat De Mauro T, Mancini F, Vedovelli M, Voghera M (1993) Lessico di frequenza d’uso dell’italiano parlato. Etas Libri, Milano De Mauro T, Mancini F, Vedovelli M, Voghera M (1993) Lessico di frequenza d’uso dell’italiano parlato. Etas Libri, Milano
38.
Zurück zum Zitat Friston KJ, Holmes AP, Worsley KJ, Poline J-P, Frith CD, Frackowiak RSJ (1995) Statistical parametric maps infunctional imaging: a general linear approach. Hum Brain Map 2:189–210CrossRef Friston KJ, Holmes AP, Worsley KJ, Poline J-P, Frith CD, Frackowiak RSJ (1995) Statistical parametric maps infunctional imaging: a general linear approach. Hum Brain Map 2:189–210CrossRef
39.
Zurück zum Zitat Cunningham WA, Raye CL, Johnson MK (2004) Implicit and explicit evaluation: fMRI correlates of valence, emotional intensity, and control in the processing of attitudes. J Cogn Neurosci 16:1717–1729CrossRefPubMed Cunningham WA, Raye CL, Johnson MK (2004) Implicit and explicit evaluation: fMRI correlates of valence, emotional intensity, and control in the processing of attitudes. J Cogn Neurosci 16:1717–1729CrossRefPubMed
40.
Zurück zum Zitat Kuchinke L, Jacobs AM, Võ ML, Conrad M, Grubich C, Herrmann M (2006) Modulation of prefrontal cortex activation by emotional words in recognition memory. Neuroreport 17:1037–1041CrossRefPubMed Kuchinke L, Jacobs AM, Võ ML, Conrad M, Grubich C, Herrmann M (2006) Modulation of prefrontal cortex activation by emotional words in recognition memory. Neuroreport 17:1037–1041CrossRefPubMed
41.
Zurück zum Zitat Fossati P, Hevenor SJ, Graham SJ, Grady C, Keightley ML, Craik F, Mayberg H (2003) In search of the emotional self: an FMRI study using positive and negative emotional words. Am J Psychiatry 160:1938–1945CrossRefPubMed Fossati P, Hevenor SJ, Graham SJ, Grady C, Keightley ML, Craik F, Mayberg H (2003) In search of the emotional self: an FMRI study using positive and negative emotional words. Am J Psychiatry 160:1938–1945CrossRefPubMed
42.
Zurück zum Zitat Maddock RJ, Garrett AS, Buonocore MH (2003) Posterior Cingulate Cortex Activation by Emotional Words: fMRI evidence from a valence decision task. Hum Brain Map 41:18–30 Maddock RJ, Garrett AS, Buonocore MH (2003) Posterior Cingulate Cortex Activation by Emotional Words: fMRI evidence from a valence decision task. Hum Brain Map 41:18–30
43.
Zurück zum Zitat Murphy JM, Roland GH, Langmore S, Kramer JH, Miller BL, Lomen-Hoerth C (2007) Continuum of frontal lobe impairment in Amyotrophic Lateral Sclerosis. Arch Neurol 64:530–534CrossRefPubMed Murphy JM, Roland GH, Langmore S, Kramer JH, Miller BL, Lomen-Hoerth C (2007) Continuum of frontal lobe impairment in Amyotrophic Lateral Sclerosis. Arch Neurol 64:530–534CrossRefPubMed
44.
Zurück zum Zitat Gur RC, Skolnick BE, Gur RE (1994) Effect of emotional discrimination tasks on cerebral blood flow: regional activation and its relation to performance. Brain Cogn 25:271–286CrossRefPubMed Gur RC, Skolnick BE, Gur RE (1994) Effect of emotional discrimination tasks on cerebral blood flow: regional activation and its relation to performance. Brain Cogn 25:271–286CrossRefPubMed
Metadaten
Titel
Right hemisphere dysfunction and emotional processing in ALS: an fMRI study
verfasst von
A. Palmieri
M. Naccarato
S. Abrahams
M. Bonato
C. D’Ascenzo
S. Balestreri
V. Cima
G. Querin
R. Dal Borgo
L. Barachino
C. Volpato
C. Semenza
E. Pegoraro
C. Angelini
G. Sorarù
Publikationsdatum
01.12.2010
Verlag
Springer-Verlag
Erschienen in
Journal of Neurology / Ausgabe 12/2010
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-010-5640-2

Weitere Artikel der Ausgabe 12/2010

Journal of Neurology 12/2010 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.