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Erschienen in: Journal of Neurology 8/2012

01.08.2012 | Original Communication

Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease

verfasst von: Pablo Martinez-Martin, Cristian Falup Pecurariu, Per Odin, Jacobus J. van Hilten, Angelo Antonini, Jose M. Rojo-Abuin, Vanderci Borges, Claudia Trenkwalder, Dag Aarsland, David J. Brooks, Kallol Ray Chaudhuri

Erschienen in: Journal of Neurology | Ausgabe 8/2012

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Abstract

Differences in the expression of non-motor symptoms (NMS) by Parkinson’s disease (PD) patients may have important implications for their management and prognosis. Gender is a basic epidemiological variable that could influence such expression. The present study evaluated the prevalence and severity of NMS by gender in an international sample of 951 PD patients, 62.63% males, using the non-motor symptoms scale (NMSS). Assessments for motor impairment and complications, global severity, and health state were also applied. All disease stages were included. No significant gender differences were found for demographic and clinical characteristics. For the entire sample, the most prevalent symptoms were Nocturia (64.88%) and Fatigue (62.78%) and the most prevalent affected domains were Sleep/Fatigue (84.02%) and Miscellaneous (82.44%). Fatigue, feelings of nervousness, feelings of sadness, constipation, restless legs, and pain were more common and severe in women. On the contrary, daytime sleepiness, dribbling saliva, interest in sex, and problems having sex were more prevalent and severe in men. Regarding the NMSS domains, Mood/Apathy and Miscellaneous problems (pain, loss of taste or smell, weight change, and excessive sweating) were predominantly affected in women and Sexual dysfunction in men. No other significant differences by gender were observed. To conclude, in this study significant differences between men and women in prevalence and severity of fatigue, mood, sexual and digestive problems, pain, restless legs, and daytime sleepiness were found. Gender-related patterns of NMS involvement may be relevant for clinical trials in PD.
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Metadaten
Titel
Gender-related differences in the burden of non-motor symptoms in Parkinson’s disease
verfasst von
Pablo Martinez-Martin
Cristian Falup Pecurariu
Per Odin
Jacobus J. van Hilten
Angelo Antonini
Jose M. Rojo-Abuin
Vanderci Borges
Claudia Trenkwalder
Dag Aarsland
David J. Brooks
Kallol Ray Chaudhuri
Publikationsdatum
01.08.2012
Verlag
Springer-Verlag
Erschienen in
Journal of Neurology / Ausgabe 8/2012
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-011-6392-3

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