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Erschienen in: Journal of Neurology 7/2016

03.05.2016 | Original Communication

Subclinical primary retinal pathology in neuromyelitis optica spectrum disorder

verfasst von: In Hye Jeong, Ho Jin Kim, Nam-Hee Kim, Kyoung Sook Jeong, Choul Yong Park

Erschienen in: Journal of Neurology | Ausgabe 7/2016

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Abstract

Foveal thickness may be a more sensitive indicator of primary retinal pathology than retinal nerve fiber layer thickness since the fovea contains no or sparse retinal nerve fiber layer, which coalesces into axons of the optic nerve. To our knowledge, few quantitative in vivo studies have investigated foveal thickness. By using optical coherence tomography, we measured foveal thickness to evaluate intrinsic retinal pathology. Seventy-two neuromyelitis optica spectrum disorder patients (99 eyes with optic neuritis and 45 eyes without optic neuritis) and 34 age-matched controls were included. Foveal thinning was observed both in eyes with non-optic neuritis (185.1 µm, p < 0.001) and optic neuritis (185.0 µm, p < 0.001) relative to controls (205.0 µm). Compared to controls, eyes with non-optic neuritis did not have peripapillary retinal nerve fiber layer thinning, but showed foveal thinning (p < 0.001). In neuromyelitis optica spectrum disorder, foveal thickness correlated with 2.5 % low contrast visual acuity, while retinal nerve fiber layer thickness correlated with high or low contrast visual acuity, extended disability status scale, and disease duration. In this study, we observed foveal thinning irrespective of optic neuritis; thus, we believe that subclinical primary retinal pathology, prior to retinal nerve fiber layer thinning, may exist in neuromyelitis optica spectrum disorder.
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Metadaten
Titel
Subclinical primary retinal pathology in neuromyelitis optica spectrum disorder
verfasst von
In Hye Jeong
Ho Jin Kim
Nam-Hee Kim
Kyoung Sook Jeong
Choul Yong Park
Publikationsdatum
03.05.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 7/2016
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-016-8138-8

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