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Journal of Neurology

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27.09.2019 | Original Communication

“Thalamic aphasia” after stroke is associated with left anterior lesion location

verfasst von: Merve Fritsch, Thomas Krause, Fabian Klostermann, Kersten Villringer, Manuela Ihrke, Christian H. Nolte

Erschienen in: Journal of Neurology | Ausgabe 1/2020

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Abstract

Background

Aphasic symptoms are typically associated with lesions of the left fronto-temporal cortex. Interestingly, aphasic symptoms have also been described in patients with thalamic strokes in anterior, paramedian or posterolateral location. So far, systematic analyses are missing.

Methods

We conducted a retrospective analysis of consecutive patients admitted to our tertiary stroke care center between January 2016 and July 2017 with image-based (MRI) proven ischemic stroke. We evaluated stroke lesion location, using 3-T MRI, and presence of aphasic symptoms.

Results

Out of 1064 patients, 104 (9.8%) presented with a thalamic stroke, 52 of which (4.9%) had an isolated lesion in the thalamus (ILT). In patients with ILT, 6/52 had aphasic symptoms. Aphasic symptoms after ILT were only present in patients with left anterior lesion location (n = 6, 100% left anterior vs. 0% other thalamic location, p < 0.001).

Conclusions

Aphasic symptoms in thalamic stroke are strongly associated with left anterior lesion location. In thalamo-cortical language networks, specifically the nuclei in the left anterior thalamus could play an important role in integration of left cortical information with disconnection leading to aphasic symptoms.

Wernicke C (1874) Der aphasische Symptomenkomplex. Cohn and Weigert, Breslau

Broca PP (1861) Remarque sur le siège de la faculté du language articulé, suivies d’une observation d’aphémie. Bull Soc Anatom Paris 6:330–357

Llano DA (2015) Chapter 9—the thalamus and language. In: Hickok G, Small SL (eds) Neurobiology of language. Academic Press, London, pp 95–114. https://doi.org/10.1016/c2011-0-07351-9 CrossRef

Murdoch BE (2001) Subcortical brain mechanisms in speech and language. Folia Phoniatr Logop 53(5):233–251. https://doi.org/10.1159/000052679 CrossRefPubMed

Wallesch CW, Papagno C (1988) Subcortical aphasia. In: Rose FC, Whurr R, Wyke MA (eds) Aphasia. Whurr Publishers, London, pp 257–287

Steriade M, Jones EG, Llinas RR (1990) Thalamic oscillations and signaling. The Neurosciences Institute publications series. Wiley, New York

Nadeau SE, Crosson B (1997) Subcortical aphasia. Brain Lang 58(3):355–402. https://doi.org/10.1006/brln.1997.1707(discussion 418–323) CrossRefPubMed

Klostermann F, Krugel LK, Ehlen F (2013) Functional roles of the thalamus for language capacities. Front Syst Neurosci 7:32. https://doi.org/10.3389/fnsys.2013.00032 CrossRefPubMedPubMedCentral

Schmahmann JD (2003) Vascular syndromes of the thalamus. Stroke 34(9):2264–2278. https://doi.org/10.1161/01.STR.0000087786.38997.9E CrossRefPubMed

10.

De Witte L, Brouns R, Kavadias D, Engelborghs S, De Deyn PP, Marien P (2011) Cognitive, affective and behavioural disturbances following vascular thalamic lesions: a review. Cortex 47(3):273–319. https://doi.org/10.1016/j.cortex.2010.09.002 CrossRefPubMed

11.

Cappa SF, Papagno C, Vallar G, Vignolo LA (1986) Aphasia does not always follow left thalamic hemorrhage: a study of five negative cases. Cortex 22(4):639–647CrossRef

12.

Bogousslavsky J, Miklossy J, Deruaz JP, Regli F (1988) Thalamic aphasia. Neurology 38(10):1662CrossRef

13.

Alexander MP, LoVerme SR Jr (1980) Aphasia after left hemispheric intracerebral hemorrhage. Neurology 30(11):1193–1202CrossRef

14.

Lhermitte F (1984) Language disorders and their relationship to thalamic lesions. Adv Neurol 42:99–113PubMed

15.

Ford AA, Triplett W, Sudhyadhom A, Gullett J, McGregor K, Fitzgerald DB, Mareci T, White K, Crosson B (2013) Broca’s area and its striatal and thalamic connections: a diffusion-MRI tractography study. Front Neuroanat 7:8. https://doi.org/10.3389/fnana.2013.00008 CrossRefPubMedPubMedCentral

16.

Kraut MA, Kremen S, Moo LR, Segal JB, Calhoun V, Hart J Jr (2002) Object activation in semantic memory from visual multimodal feature input. J Cogn Neurosci 14(1):37–47. https://doi.org/10.1162/089892902317205302 CrossRefPubMed

17.

Hotter B, Pittl S, Ebinger M, Oepen G, Jegzentis K, Kudo K, Rozanski M, Schmidt WU, Brunecker P, Xu C, Martus P, Endres M, Jungehulsing GJ, Villringer A, Fiebach JB (2009) Prospective study on the mismatch concept in acute stroke patients within the first 24 h after symptom onset—1000 plus study. BMC Neurol 9:60. https://doi.org/10.1186/1471-2377-9-60 CrossRefPubMedPubMedCentral

18.

Carrera E, Bogousslavsky J (2006) The thalamus and behavior: effects of anatomically distinct strokes. Neurology 66(12):1817–1823. https://doi.org/10.1212/01.wnl.0000219679.95223.4c CrossRefPubMed

19.

Kalbe E, Reinhold N, Brand M, Markowitsch HJ, Kessler J (2005) A new test battery to assess aphasic disturbances and associated cognitive dysfunctions—German normative data on the aphasia check list. J Clin Exp Neuropsychol 27(7):779–794. https://doi.org/10.1080/13803390490918273 CrossRefPubMed

20.

Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V et al (1989) Measurements of acute cerebral infarction: a clinical examination scale. Stroke 20(7):864–870CrossRef

21.

Gorelick PB, Hier DB, Benevento L, Levitt S, Tan W (1984) Aphasia after left thalamic infarction. Arch Neurol 41(12):1296–1298CrossRef

22.

Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, Hill MD, Patronas N, Latour L, Warach S (2007) Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet 369(9558):293–298. https://doi.org/10.1016/S0140-6736(07)60151-2 CrossRefPubMedPubMedCentral

23.

Lim-Hing K, Rincon F (2017) Secondary hematoma expansion and perihemorrhagic edema after intracerebral hemorrhage: from bench work to practical aspects. Front Neurol 8:74. https://doi.org/10.3389/fneur.2017.00074 CrossRefPubMedPubMedCentral

24.

Ehlen F, Schoenecker T, Kuhn AA, Klostermann F (2014) Differential effects of deep brain stimulation on verbal fluency. Brain Lang 134:23–33. https://doi.org/10.1016/j.bandl.2014.04.002 CrossRefPubMed

25.

Wahl M, Marzinzik F, Friederici AD, Hahne A, Kupsch A, Schneider GH, Saddy D, Curio G, Klostermann F (2008) The human thalamus processes syntactic and semantic language violations. Neuron 59(5):695–707. https://doi.org/10.1016/j.neuron.2008.07.011 CrossRefPubMed

26.

Kuncel AM, Cooper SE, Grill WM (2008) A method to estimate the spatial extent of activation in thalamic deep brain stimulation. Clin Neurophysiol 119(9):2148–2158. https://doi.org/10.1016/j.clinph.2008.02.025 CrossRefPubMedPubMedCentral

27.

Crosson B (2013) Thalamic mechanisms in language: a reconsideration based on recent findings and concepts. Brain Lang 126(1):73–88. https://doi.org/10.1016/j.bandl.2012.06.011 CrossRefPubMed

28.

Saur D, Kreher BW, Schnell S, Kummerer D, Kellmeyer P, Vry MS, Umarova R, Musso M, Glauche V, Abel S, Huber W, Rijntjes M, Hennig J, Weiller C (2008) Ventral and dorsal pathways for language. Proc Natl Acad Sci USA 105(46):18035–18040. https://doi.org/10.1073/pnas.0805234105 CrossRefPubMed

29.

Kummerer D, Hartwigsen G, Kellmeyer P, Glauche V, Mader I, Kloppel S, Suchan J, Karnath HO, Weiller C, Saur D (2013) Damage to ventral and dorsal language pathways in acute aphasia. Brain 136(Pt 2):619–629. https://doi.org/10.1093/brain/aws354 CrossRefPubMedPubMedCentral

30.

Yakovlev PI, Locke S (1961) Limbic nuclei of thalamus and connections of limbic cortex. III. Corticocortical connections of the anterior cingulate gyrus, the cingulum, and the subcallosal bundle in monkey. Arch Neurol 5:364–400CrossRef

31.

Vogt BA, Pandya DN, Rosene DL (1987) Cingulate cortex of the rhesus monkey: I. Cytoarchitecture and thalamic afferents. J Comp Neurol 262(2):256–270. https://doi.org/10.1002/cne.902620207 CrossRefPubMed

32.

Ojemann GA (1982) Models of the brain organization for higher integrative functions derived with electrical stimulation techniques. Hum Neurobiol 1(4):243–249PubMed

33.

McCormick DA, Bal T (1997) Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci 20:185–215. https://doi.org/10.1146/annurev.neuro.20.1.185 CrossRefPubMed

34.

Alain C, Reinke K, McDonald KL, Chau W, Tam F, Pacurar A, Graham S (2005) Left thalamo-cortical network implicated in successful speech separation and identification. Neuroimage 26(2):592–599. https://doi.org/10.1016/j.neuroimage.2005.02.006 CrossRefPubMed

35.

Assaf M, Calhoun VD, Kuzu CH, Kraut MA, Rivkin PR, Hart J Jr, Pearlson GD (2006) Neural correlates of the object-recall process in semantic memory. Psychiatry Res 147(2–3):115–126. https://doi.org/10.1016/j.pscychresns.2006.01.002 CrossRefPubMed

36.

Hillis AE, Barker PB, Wityk RJ, Aldrich EM, Restrepo L, Breese EL, Work M (2004) Variability in subcortical aphasia is due to variable sites of cortical hypoperfusion. Brain Lang 89(3):524–530. https://doi.org/10.1016/j.bandl.2004.01.007 CrossRefPubMed

37.

Sebastian R, Schein MG, Davis C, Gomez Y, Newhart M, Oishi K, Hillis AE (2014) Aphasia or neglect after thalamic stroke: the various ways they may be related to cortical hypoperfusion. Front Neurol 5:231. https://doi.org/10.3389/fneur.2014.00231 CrossRefPubMedPubMedCentral

38.

Stenset V, Grambaite R, Reinvang I, Hessen E, Cappelen T, Bjornerud A, Gjerstad L, Fladby T (2007) Diaschisis after thalamic stroke: a comparison of metabolic and structural changes in a patient with amnesic syndrome. Acta Neurol Scand Suppl 187:68–71. https://doi.org/10.1111/j.1600-0404.2007.00851.x CrossRefPubMed

39.

Baron JC, Levasseur M, Mazoyer B, Legault-Demare F, Mauguiere F, Pappata S, Jedynak P, Derome P, Cambier J, Tran-Dinh S et al (1992) Thalamocortical diaschisis: positron emission tomography in humans. J Neurol Neurosurg Psychiatry 55(10):935–942CrossRef

40.

Khalil AA, Ostwaldt AC, Nierhaus T, Ganeshan R, Audebert HJ, Villringer K, Villringer A, Fiebach JB (2017) Relationship between changes in the temporal dynamics of the blood-oxygen-level-dependent signal and hypoperfusion in acute ischemic stroke. Stroke 48(4):925–931. https://doi.org/10.1161/STROKEAHA.116.015566 CrossRefPubMed

41.

Brierley JB, Beck E (1959) The significance in human stereotactic brain surgery of individual variation in the diencephalon and globus pallidus. J Neurol Neurosurg Psychiatry 22:287–298CrossRef

42.

Krause T, Brunecker P, Pittl S, Taskin B, Laubisch D, Winter B, Lentza ME, Malzahn U, Villringer K, Villringer A, Jungehulsing GJ (2012) Thalamic sensory strokes with and without pain: differences in lesion patterns in the ventral posterior thalamus. J Neurol Neurosurg Psychiatry 83(8):776–784. https://doi.org/10.1136/jnnp-2011-301936 CrossRefPubMed

Titel: “Thalamic aphasia” after stroke is associated with left anterior lesion location
verfasst von: Merve Fritsch
Thomas Krause
Fabian Klostermann
Kersten Villringer
Manuela Ihrke
Christian H. Nolte
Publikationsdatum: 27.09.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 1/2020
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-019-09560-1

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“Thalamic aphasia” after stroke is associated with left anterior lesion location

Abstract

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Abstract

Background

Methods

Results

Conclusions

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