Skip to main content
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 2/2007

01.02.2007 | Case Report

In vivo confocal microscopy in hydroxychloroquine-induced keratopathy

verfasst von: André Dosso, Elisabeth Rungger-Brändle

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 2/2007

Einloggen, um Zugang zu erhalten

Abstract

Background

Vortex keratopathy, arising as a side effect of several medications, is characterized by golden-brown deposits in the cornea.

Methods

A 41-year-old woman treated for sarcoidosis with hydroxychloroquine therapy and suffering from vortex keratopathy was examined by in vivo confocal microscopy. Scans of both corneas were performed.

Results

By slit lamp examination, the left but not the right eye showed a golden-brown deposit throughout the cornea. In vivo confocal microscopy revealed the presence of highly reflective, dot-like intracellular inclusions concentrated in the basal epithelial layer. They were also detected within the anterior and posterior stroma, but not within the endothelium. In regions of the anterior stroma, devoid of inclusions, hyperreflective ramified keratocytes were observed, forming an extended interconnecting network.

Conclusion

In addition to the granular deposits, in vivo confocal microscopy revealed hyperreflective, possibly phagocytic keratocytes.
Literatur
1.
Zurück zum Zitat Chakravarti S, Wu F, Vij N, Roberts L, Joyce S (2004) Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea. Invest Ophthalmol Vis Sci 45:3475–3484PubMedCrossRef Chakravarti S, Wu F, Vij N, Roberts L, Joyce S (2004) Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea. Invest Ophthalmol Vis Sci 45:3475–3484PubMedCrossRef
2.
Zurück zum Zitat Ciancaglini M, Carpineto P, Zuppardi E, Nubile M, Doronzo E, Mastropasqua L (2001) In vivo confocal microscopy of patients with amiodarone-induced keratopathy. Cornea 20:368–373PubMedCrossRef Ciancaglini M, Carpineto P, Zuppardi E, Nubile M, Doronzo E, Mastropasqua L (2001) In vivo confocal microscopy of patients with amiodarone-induced keratopathy. Cornea 20:368–373PubMedCrossRef
3.
Zurück zum Zitat D’Amico DJ, Kenyon KR, Ruskin JN (1981) Amiodarone keratopathy: drug-induced lipid storage disease. Arch Ophthalmol 99:257–261PubMed D’Amico DJ, Kenyon KR, Ruskin JN (1981) Amiodarone keratopathy: drug-induced lipid storage disease. Arch Ophthalmol 99:257–261PubMed
4.
Zurück zum Zitat Dua HS, Singh A, Gomes JA, Laibson PR, Donoso LA, Tyagi S (1996) Vortex or whorl formation of cultured human corneal epithelial cells induced by magnetic fields. Eye 10(Pt 4):447–450PubMed Dua HS, Singh A, Gomes JA, Laibson PR, Donoso LA, Tyagi S (1996) Vortex or whorl formation of cultured human corneal epithelial cells induced by magnetic fields. Eye 10(Pt 4):447–450PubMed
5.
Zurück zum Zitat Hirst LW, Sanborn G, Green WR, Miller NR, Heath WD (1982) Amodiaquine ocular changes. Arch Ophthalmol 100:1300–1304PubMed Hirst LW, Sanborn G, Green WR, Miller NR, Heath WD (1982) Amodiaquine ocular changes. Arch Ophthalmol 100:1300–1304PubMed
6.
Zurück zum Zitat Hollander DA, Aldave AJ (2004) Drug-induced corneal complications. Curr Opin Ophthalmol 15:541–548PubMedCrossRef Hollander DA, Aldave AJ (2004) Drug-induced corneal complications. Curr Opin Ophthalmol 15:541–548PubMedCrossRef
7.
Zurück zum Zitat Ingram DV, Jaggarao NS, Chamberlain DA (1982) Ocular changes resulting from therapy with amiodarone. Br J Ophthalmol 66:676–679PubMed Ingram DV, Jaggarao NS, Chamberlain DA (1982) Ocular changes resulting from therapy with amiodarone. Br J Ophthalmol 66:676–679PubMed
8.
Zurück zum Zitat Poole CA, Brookes NH, Clover GM (2003) Confocal imaging of the human keratocyte network using the vital dye 5-chloromethylfluorescein diacetate. Clin Exp Ophthalmol 31:147–154CrossRef Poole CA, Brookes NH, Clover GM (2003) Confocal imaging of the human keratocyte network using the vital dye 5-chloromethylfluorescein diacetate. Clin Exp Ophthalmol 31:147–154CrossRef
9.
Zurück zum Zitat Pulhorn G, Thiel HJ (1976) [Ultrastructural aspects of chloroquin-keratopathy (author’s transl)]. Albrecht Von Graefe's Arch Klin Exp Ophthalmol 201:89–99CrossRef Pulhorn G, Thiel HJ (1976) [Ultrastructural aspects of chloroquin-keratopathy (author’s transl)]. Albrecht Von Graefe's Arch Klin Exp Ophthalmol 201:89–99CrossRef
10.
Zurück zum Zitat Slowik C, Somodi S, von Gruben C, Richter A, Guthoff R (1997) [Detection of morphological corneal changes caused by chloroquine therapy using confocal in vivo microscopy]. Ophthalmologe 94:147–151PubMedCrossRef Slowik C, Somodi S, von Gruben C, Richter A, Guthoff R (1997) [Detection of morphological corneal changes caused by chloroquine therapy using confocal in vivo microscopy]. Ophthalmologe 94:147–151PubMedCrossRef
Metadaten
Titel
In vivo confocal microscopy in hydroxychloroquine-induced keratopathy
verfasst von
André Dosso
Elisabeth Rungger-Brändle
Publikationsdatum
01.02.2007
Verlag
Springer-Verlag
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 2/2007
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-006-0365-8

Weitere Artikel der Ausgabe 2/2007

Graefe's Archive for Clinical and Experimental Ophthalmology 2/2007 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Open Access 22.02.2024 | Peeling | Originalien

Selektive Vitalfarbstoffe in der Makulachirurgie

Erhöhen sie die Wahrscheinlichkeit der intraoperativen ILM-Identifizierung auch bei einem erfahrenen Operateur?

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.