nach oben

Graefe's Archive for Clinical and Experimental Ophthalmology

Erschienen in:

01.12.2012 | Basic Science

Associations between metabolic syndrome and syndrome components and retinal microvascular signs in a rural Chinese population: the Handan Eye Study

verfasst von: Yang Zhao, Ke Yang, Fenghua Wang, Yuanbo Liang, Yi Peng, Ran Shen, Tienyin Wong, Ningli Wang

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 12/2012

Einloggen, um Zugang zu erhalten

Abstract

Background

Our purpose was to determine the relationship of metabolic syndrome (MetS) and its components with retinal microvascular abnormalities in a rural Chinese population.

Methods

The Handan Eye Study, a population-based survey, recruited 6,830 (90.4 % of eligible) rural Chinese ≥30 years of age. A diagnosis of metabolic syndrome was based on the International Diabetes Federation definition. Retinal microvascular signs and arteriolar and venular diameters were assessed from fundus photographs by graders who were trained at the Retinal Vascular Imaging Centre, University of Melbourne.

Results

After adjusting for age, gender, and smoking status, 5,519 participants with MetS, or with the specific components of large waist circumference, elevated blood pressure (BP), or elevated fasting blood glucose (FG), were more likely to have retinopathy, arteriovenous nicking, focal arteriolar narrowing, enhanced arteriolar wall reflex, and generalized retinal arteriolar narrowing than those without MetS or the corresponding component. Individuals with elevated triglycerides were significantly more likely to have arteriovenous nicking and retinopathy.

Conclusion

These results show that individual components of MetS are associated with different retinal microvascular signs and with changes in retinal arteriolar and venular diameters.

Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA (2002) Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 156:1070–1077PubMedCrossRef

Lorenzo C, Okoloise M, Williams K, Stern MP, Haffner SM (2003) The metabolic syndrome as predictor of type 2 diabetes: the San Antonio heart study. Diabetes Care 26(11):3153–9PubMedCrossRef

de Jongh RT, Serné EH, IJzerman RG, de Vries G, Stehouwer CD (2004) Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation 109:2529–2535PubMedCrossRef

Nguyen TT, Wong TY (2006) Retinal vascular manifestations of metabolic disorders. Trends Endocrinol Metab 17:262–268PubMedCrossRef

Kawasaki R, Tielsch JM, Wang JJ, Wong TY, Mitchell P, Tano Y, Tominaga M, Oizumi T, Daimon M, Kato T, Kawata S, Kayama T, Yamashita H (2008) The metabolic syndrome and retinal microvascular signs in a Japanese population: The Funagata study. Br J Ophthalmol 92:161–166PubMedCrossRef

Keenan JD, Fan AZ, Klein R (2009) Retinopathy in nondiabetic persons with the metabolic syndrome: findings from the Third National Health and Nutrition Examination Survey. Am J Ophthalmol 147:934–944, 944.e1-944.e2PubMedCrossRef

Wong TY, Duncan BB, Golden SH, Klein R, Couper DJ, Klein BE, Hubbard LD, Sharrett AR, Schmidt MI (2004) Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk in Communities study. Invest Ophthalmol Vis Sci 45:2949–2954PubMedCrossRef

Hubbard LD, Brothers RJ, King WN, Clegg LX, Klein R, Cooper LS, Sharrett AR, Davis MD, Cai J (1999) Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 106:2269–2280PubMedCrossRef

Klein R, Sharrett AR, Klein BE, Chambless LE, Cooper LS, Hubbard LD, Evans G (2000) Are retinal arteriolar abnormalities related to atherosclerosis?: The Atherosclerosis Risk in Communities Study. Arterioscler Thromb Vasc Biol 20:1644–1650PubMedCrossRef

10.

Leung H, Wang JJ, Rochtchina E, Tan AG, Wong TY, Hubbard LD, Klein R, Mitchell P (2003) Computer-assisted retinal vessel measurement in an older population: correlation between right and left eyes. Clin Experiment Ophthalmol 31:326–330PubMedCrossRef

11.

Wang FH, Liang YB, Zhang F, Wang JJ, Wei WB, Tao QS, Sun LP, Friedman DS, Wang NL, Wong TY (2003) Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study. Hypertension 42:534–541PubMedCrossRef

12.

Wong TY, Islam FM, Klein R, Klein BE, Cotch MF, Castro C, Sharrett AR, Shahar E (2006) Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci 47:2341–2350PubMedCrossRef

13.

Leung H, Wang JJ, Rochtchina E, Wong TY, Klein R, Mitchell P (2005) Dyslipidaemia and microvascular disease in the retina. Eye (Lond) 19:861–868CrossRef

14.

Ikram MK, de Jong FJ, Vingerling JR, Witteman JC, Hofman A, Breteler MM, de Jong PT (2004) Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci 45:2129–2134PubMedCrossRef

15.

Yuan Y, Ikram MK, Vingerling JR, Jiang S, Lin H, Liu M, Ren L, Gao X (2011) Retinal vascular caliber and metabolic syndrome in a Chinese population. Intern Med J. doi:10.1111/j.1445-5994.2011.02470.x

16.

Wang S, Xu L, Jonas JB, Wang YS, Wang Y, Yang H, Li J (2006) Retinal vascular abnormalities in adult Chinese in rural and urban Beijing: the Beijing Eye Study. Ophthalmology 113(10):1752–1757PubMedCrossRef

17.

Nestel P, Lyu R, Low LP, Sheu WH, Nitiyanant W, Saito I, Tan CE (2007) Metabolic syndrome: Recent prevalence in East and Southeast Asian populations. Asia Pac J Clin Nutr 16:362–367PubMed

18.

Liang YB, Friedman DS, Wong TY, Wang FH, Duan XR, Yang XH, Zhou Q, Tao Q, Zhan SY, Sun LP, Wang NL (2009) Handan Eye Study Group. Rationale, design, methodology, and baseline data of a population-based study in rural China: the Handan Eye Study. Ophthalmic Epidemiol 16:115–127PubMedCrossRef

19.

Wang FH, Liang YB, Zhang F, Wang JJ, Wei WB, Tao QS, Sun LP, Friedman DS, Wang NL, Wong TY (2009) Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology 116:461–467PubMedCrossRef

20.

Manolio TA, Fishel SC, Beattie C, Torres J, Christopherson R, Merritt WT, Whelton PK (1988) Evaluation of the Dinamap continuous blood pressure monitor. Am J Hypertens 1(3):161S–167SPubMed

21.

Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome—a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 23:469–480PubMedCrossRef

22.

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285:2486–2497CrossRef

23.

Kaushik S, Tan AG, Mitchell P, Wang JJ (2007) Prevalence and associations of enhanced retinal arteriolar light reflex: A new look at an old sign. Ophthalmology 114:113–120PubMedCrossRef

24.

Wong TY, Knudtson MD, Klein R, Klein BE, Meuer SM, Hubbard LD (2004) Computer-assisted measurement of retinal vessel diameters in the Beaver Dam Eye Study: methodology, correlation between eyes, and effect of refractive errors. Ophthalmology 111:1183–1190PubMedCrossRef

25.

Liew G, Sharrett AR, Kronmal R, Klein R, Wong TY, Mitchell P, Kifley A, Wang JJ (2007) Measurement of retinal vascular caliber: issues and alternatives to using the arteriole to venule ratio. Invest Ophthalmol Vis Sci 48:52–57PubMedCrossRef

26.

Klein R, Sharrett AR, Klein BE, Moss SE, Folsom AR, Wong TY, Brancati FL, Hubbard LD, Couper D (2002) The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes: The Atherosclerosis Risk in Communities Study. Ophthalmology 109:1225–1234PubMedCrossRef

27.

Sharrett AR, Hubbard LD, Cooper LS, Sorlie PD, Brothers RJ, Nieto FJ, Pinsky JL, Klein R (1999) Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 150:263–270PubMedCrossRef

28.

Wong TY, Hubbard LD, Klein R, Marino EK, Kronmal R, Sharrett AR, Siscovick DS, Burke G, Tielsch JM (2002) Retinal microvascular abnormalities and blood pressure in older people: the Cardiovascular Health Study. Br J Ophthalmol 86:1007–1013PubMedCrossRef

29.

Tanabe Y, Kawasaki R, Wang JJ, Wong TY, Mitchell P, Daimon M, Oizumi T, Kato T, Kawata S, Kayama T, Yamashita H (2010) Retinal arteriolar narrowing predicts 5-year risk of hypertension in Japanese people: the Funagata study. Microcirculation 17:94–102PubMedCrossRef

30.

Saito K, Nagao Y, Yamashita H, Kawasaki R (2011) Screening for retinal vessel caliber and its association with metabolic syndrome in Japanese adults. Metab Syndr Relat Disord 9:427–432PubMedCrossRef

31.

Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, Whelton PK, He J (2005) Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 365:1398–1405PubMedCrossRef

32.

He Y, Jiang B, Wang J, Feng K, Chang Q, Fan L, Li X, Hu FB (2006) Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population. J Am Coll Cardiol 47:1588–1594PubMedCrossRef

33.

Thomas GN, Ho SY, Janus ED, Lam KS, Hedley AJ, Lam TH (2005) The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) prevalence of the metabolic syndrome in a Chinese population. Diabetes Res Clin Pract 67:251–257PubMedCrossRef

34.

Wang JJ, Taylor B, Wong TY, Chua B, Rochtchina E, Klein R, Mitchell P (2006) Retinal vessel diameters and obesity: a population-based study in older persons. Obesity (Silver Spring) 14(2):206–214CrossRef

35.

Klein R, Klein BE, Moss SE, Wong TY, Hubbard L, Cruickshanks KJ, Palta M (2003) Retinal vascular abnormalities in persons with type 1 diabetes: the Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVIII. Ophthalmology 110:2118–2125PubMedCrossRef

36.

Leung H, Wang JJ, Rochtchina E, Wong TY, Klein R, Mitchell P (2004) Impact of current and past blood pressure on retinal arteriolar diameter in an older population. J Hypertens 22:1543–1549PubMedCrossRef

37.

Wong TY, Klein R, Klein BE, Meuer SM, Hubbard LD (2003) Retinal vessel diameters and their associations with age and blood pressure. Invest Ophthalmol Vis Sci 44:4644–4650PubMedCrossRef

38.

Kifley A, Wang JJ, Cugati S, Wong TY, Mitchell P (2008) Retinal vascular caliber and the long-term risk of diabetes and impaired fasting glucose: the Blue Mountains Eye Study. Microcirculation 15:373–377PubMedCrossRef

Titel: Associations between metabolic syndrome and syndrome components and retinal microvascular signs in a rural Chinese population: the Handan Eye Study
verfasst von: Yang Zhao
Ke Yang
Fenghua Wang
Yuanbo Liang
Yi Peng
Ran Shen
Tienyin Wong
Ningli Wang
Publikationsdatum: 01.12.2012
Verlag: Springer-Verlag
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 12/2012
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-012-2109-2

Neu im Fachgebiet Augenheilkunde

08.04.2024 | Therapieverfahren in der Augenheilkunde | CME

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Associations between metabolic syndrome and syndrome components and retinal microvascular signs in a rural Chinese population: the Handan Eye Study

Abstract

Background

Methods

Results

Conclusion

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2012

Summary of prognostic factors for choroidal neovascularization due to pathological myopia treated by intravitreal bevacizumab injection

Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %)

Curbside Consultation in Cornea and External Disease: 49 Clinical Questions Editors: Francis W. Price Jr., Marianne O. Price, Erik Letko, 2010, 272 pp. , Softcover ISBN: 978-1-55642-931-6 Slack Inc

Success rates of retinal detachment surgery: routine versus emergency setting

Novel diagnosis of fungal endophthalmitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA

Ring-shaped corneoscleral lamellar keratoplasty guided by high-definition optical coherence tomography and Scheimpflug imaging for severe Terrien’s marginal corneal degeneration

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde