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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 5/2013

01.05.2013 | Review Article

Graft versus host disease: clinical evaluation, diagnosis and management

verfasst von: Edgar M. Espana, Sejal Shah, Marcony R. Santhiago, Arun D. Singh

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 5/2013

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Abstract

Graft versus H\host disease (GVHD) can be a devastating complication following bone marrow transplantation. Acute or chronic systemic GVHD can be lethal, and severe damage of different organs and tissues can occur with both types of GVHD. Ocular involvement, either in an acute or chronic presentation, may range from mild to severe with accompanying vision loss present in 60–90 % of patients. Chronic ocular GVHD, the most common form of GVHD, affects mainly the lacrimal gland, meibomian glands, cornea and conjunctiva, mimicking other immunologically mediated inflammatory diseases of the ocular surface without specific symptoms or signs. However, dry eye disease is the main manifestation of GVHD. The long-term treatment of ocular GVHD continues to be challenging and involves a multidisciplinary approach wherein the ophthalmologist plays a major role. Besides systemic immunosuppression and ocular lubricants, topical steroids and topical cyclosporine are commonly prescribed. Newer therapeutic interventions for moderate and severe ocular GVHD include the use of serum eye drops and scleral contact lenses. In this manuscript, we review the mechanisms, clinical findings, and treatment of ocular GVHD.
Literatur
1.
2.
Zurück zum Zitat Ferrara JL, Levine JE, Reddy P, Holler E (2009) Graft-versus-host disease. Lancet 373:1550–1561PubMedCrossRef Ferrara JL, Levine JE, Reddy P, Holler E (2009) Graft-versus-host disease. Lancet 373:1550–1561PubMedCrossRef
3.
Zurück zum Zitat de la Morena MT, Gatti RA (2010) A history of bone marrow transplantation. Immunol Allergy Clin North Am 30:1–15PubMedCrossRef de la Morena MT, Gatti RA (2010) A history of bone marrow transplantation. Immunol Allergy Clin North Am 30:1–15PubMedCrossRef
4.
Zurück zum Zitat Choi SW, Levine JE, Ferrara JL (2010) Pathogenesis and management of graft-versus-host disease. Immunol Allergy Clin North Am 30:75–101PubMedCrossRef Choi SW, Levine JE, Ferrara JL (2010) Pathogenesis and management of graft-versus-host disease. Immunol Allergy Clin North Am 30:75–101PubMedCrossRef
5.
Zurück zum Zitat Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D, Arny M, Thomas L, Boyse EA (1989) Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A 86:3828–3832PubMedCrossRef Broxmeyer HE, Douglas GW, Hangoc G, Cooper S, Bard J, English D, Arny M, Thomas L, Boyse EA (1989) Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci U S A 86:3828–3832PubMedCrossRef
6.
Zurück zum Zitat Barker JN, Krepski TP, DeFor TE, Davies SM, Wagner JE, Weisdorf DJ (2002) Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant 8:257–260PubMedCrossRef Barker JN, Krepski TP, DeFor TE, Davies SM, Wagner JE, Weisdorf DJ (2002) Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant 8:257–260PubMedCrossRef
7.
Zurück zum Zitat Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C, Goldman A, Kersey J, Krivit W, MacMillan ML, Orchard PJ, Peters C, Weisdorf DJ, Ramsay NK, Davies SM (2002) Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 100:1611–1618PubMed Wagner JE, Barker JN, DeFor TE, Baker KS, Blazar BR, Eide C, Goldman A, Kersey J, Krivit W, MacMillan ML, Orchard PJ, Peters C, Weisdorf DJ, Ramsay NK, Davies SM (2002) Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival. Blood 100:1611–1618PubMed
8.
Zurück zum Zitat Uchino M, Ogawa Y, Uchino Y, Mori T, Okamoto S, Tsubota K (2012) Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation. Br J Ophthalmol 96:34–37PubMedCrossRef Uchino M, Ogawa Y, Uchino Y, Mori T, Okamoto S, Tsubota K (2012) Comparison of stem cell sources in the severity of dry eye after allogeneic haematopoietic stem cell transplantation. Br J Ophthalmol 96:34–37PubMedCrossRef
9.
Zurück zum Zitat Platzbecker U, Ehninger G, Bornhauser M (2004) Allogeneic transplantation of CD34+ selected hematopoietic cells—clinical problems and current challenges. Leuk Lymphoma 45:447–453PubMedCrossRef Platzbecker U, Ehninger G, Bornhauser M (2004) Allogeneic transplantation of CD34+ selected hematopoietic cells—clinical problems and current challenges. Leuk Lymphoma 45:447–453PubMedCrossRef
10.
Zurück zum Zitat Wagner JE, Thompson JS, Carter SL, Kernan NA (2005) Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II-III trial. Lancet 366:733–741PubMedCrossRef Wagner JE, Thompson JS, Carter SL, Kernan NA (2005) Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II-III trial. Lancet 366:733–741PubMedCrossRef
11.
Zurück zum Zitat Coghill JM, Sarantopoulos S, Moran TP, Murphy WJ, Blazar BR, Serody JS (2011) Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. Blood 117:3268–3276PubMedCrossRef Coghill JM, Sarantopoulos S, Moran TP, Murphy WJ, Blazar BR, Serody JS (2011) Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new. Blood 117:3268–3276PubMedCrossRef
12.
Zurück zum Zitat Socie G, Blazar BR (2009) Acute graft-versus-host disease: from the bench to the bedside. Blood 114:4327–4336PubMedCrossRef Socie G, Blazar BR (2009) Acute graft-versus-host disease: from the bench to the bedside. Blood 114:4327–4336PubMedCrossRef
13.
Zurück zum Zitat Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, Martin P, Chien J, Przepiorka D, Couriel D, Cowen EW, Dinndorf P, Farrell A, Hartzman R, Henslee-Downey J, Jacobsohn D, McDonald G, Mittleman B, Rizzo JD, Robinson M, Schubert M, Schultz K, Shulman H, Turner M, Vogelsang G, Flowers ME (2005) Biol Blood Marrow Transplant 11:945–956PubMedCrossRef Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ, Martin P, Chien J, Przepiorka D, Couriel D, Cowen EW, Dinndorf P, Farrell A, Hartzman R, Henslee-Downey J, Jacobsohn D, McDonald G, Mittleman B, Rizzo JD, Robinson M, Schubert M, Schultz K, Shulman H, Turner M, Vogelsang G, Flowers ME (2005) Biol Blood Marrow Transplant 11:945–956PubMedCrossRef
14.
Zurück zum Zitat Ram R, Gafter-Gvili A, Yeshurun M, Paul M, Raanani P, Shpilberg O (2009) Prophylaxis regimens for GVHD: systematic review and meta-analysis. Bone Marrow Transplant 43:643–653PubMedCrossRef Ram R, Gafter-Gvili A, Yeshurun M, Paul M, Raanani P, Shpilberg O (2009) Prophylaxis regimens for GVHD: systematic review and meta-analysis. Bone Marrow Transplant 43:643–653PubMedCrossRef
15.
Zurück zum Zitat Sale GE (1996) Does graft-versus-host disease attack epithelial stem cells? Mol Med Today 2:114–119PubMedCrossRef Sale GE (1996) Does graft-versus-host disease attack epithelial stem cells? Mol Med Today 2:114–119PubMedCrossRef
16.
Zurück zum Zitat Ogawa Y, Okamoto S, Wakui M, Watanabe R, Yamada M, Yoshino M, Ono M, Yang HY, Mashima Y, Oguchi Y, Ikeda Y, Tsubota K (1999) Dry eye after haematopoietic stem cell transplantation. Br J Ophthalmol 83:1125–1130PubMedCrossRef Ogawa Y, Okamoto S, Wakui M, Watanabe R, Yamada M, Yoshino M, Ono M, Yang HY, Mashima Y, Oguchi Y, Ikeda Y, Tsubota K (1999) Dry eye after haematopoietic stem cell transplantation. Br J Ophthalmol 83:1125–1130PubMedCrossRef
17.
18.
Zurück zum Zitat Westeneng AC, Hettinga Y, Lokhorst H, Verdonck L, van Dorp S, Rothova A (2010) Ocular graft-versus-host disease after allogeneic stem cell transplantation. Cornea 29:758–763PubMed Westeneng AC, Hettinga Y, Lokhorst H, Verdonck L, van Dorp S, Rothova A (2010) Ocular graft-versus-host disease after allogeneic stem cell transplantation. Cornea 29:758–763PubMed
19.
Zurück zum Zitat Dietrich-Ntoukas T, Cursiefen C, Westekemper H, Eberwein P, Reinhard T, Bertz H, Nepp J, Lawitschka A, Heiligenhaus A, Seitz B, Messmer EM, Meyer-ter-Vehn T, Basara N, Greinix H, Datiles MB, Lee SJ, Pavletic SZ, Wolff D (2012) Diagnosis and treatment of ocular chronic graft-versus-host disease: report from the German-Austrian-Swiss Consensus Conference on Clinical Practice in chronic GVHD. Cornea 31:299–310PubMedCrossRef Dietrich-Ntoukas T, Cursiefen C, Westekemper H, Eberwein P, Reinhard T, Bertz H, Nepp J, Lawitschka A, Heiligenhaus A, Seitz B, Messmer EM, Meyer-ter-Vehn T, Basara N, Greinix H, Datiles MB, Lee SJ, Pavletic SZ, Wolff D (2012) Diagnosis and treatment of ocular chronic graft-versus-host disease: report from the German-Austrian-Swiss Consensus Conference on Clinical Practice in chronic GVHD. Cornea 31:299–310PubMedCrossRef
20.
Zurück zum Zitat West RH, Szer J, Pedersen JS (1991) Ocular surface and lacrimal disturbances in chronic graft-versus-host disease: the role of conjunctival biopsy. Aust N Z J Ophthalmol 19:187–191PubMedCrossRef West RH, Szer J, Pedersen JS (1991) Ocular surface and lacrimal disturbances in chronic graft-versus-host disease: the role of conjunctival biopsy. Aust N Z J Ophthalmol 19:187–191PubMedCrossRef
21.
Zurück zum Zitat Ogawa Y, Kuwana M (2003) Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Cornea 22:S19–S27PubMedCrossRef Ogawa Y, Kuwana M (2003) Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Cornea 22:S19–S27PubMedCrossRef
22.
Zurück zum Zitat Riemens A, Te BL, Imhof S, Kuball J, Rothova A (2010) Current insights into ocular graft-versus-host disease. Curr Opin Ophthalmol 21:485–494PubMedCrossRef Riemens A, Te BL, Imhof S, Kuball J, Rothova A (2010) Current insights into ocular graft-versus-host disease. Curr Opin Ophthalmol 21:485–494PubMedCrossRef
23.
Zurück zum Zitat Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Kamoi M, Uchino M, Yaguchi S, Dogru M, Tsubota K (2011) Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy. Mol Vis 17:2533–2543PubMed Ban Y, Ogawa Y, Ibrahim OM, Tatematsu Y, Kamoi M, Uchino M, Yaguchi S, Dogru M, Tsubota K (2011) Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy. Mol Vis 17:2533–2543PubMed
24.
Zurück zum Zitat Tabbara KF, Al-Ghamdi A, Al-Mohareb F, Ayas M, Chaudhri N, Al-Sharif F, Al-Zahrani H, Mohammed SY, Nassar A, Aljurf M (2009) Ocular findings after allogeneic hematopoietic stem cell transplantation. Ophthalmology 116:1624–1629PubMedCrossRef Tabbara KF, Al-Ghamdi A, Al-Mohareb F, Ayas M, Chaudhri N, Al-Sharif F, Al-Zahrani H, Mohammed SY, Nassar A, Aljurf M (2009) Ocular findings after allogeneic hematopoietic stem cell transplantation. Ophthalmology 116:1624–1629PubMedCrossRef
25.
Zurück zum Zitat Koch KR, Joussen AM, Huber KK (2011) Ocular involvement in chronic graft-versus-host disease: therapeutic approaches to complicated courses. Cornea 30:107–113PubMedCrossRef Koch KR, Joussen AM, Huber KK (2011) Ocular involvement in chronic graft-versus-host disease: therapeutic approaches to complicated courses. Cornea 30:107–113PubMedCrossRef
26.
Zurück zum Zitat Savini G, Prabhawasat P, Kojima T, Espana E (2008) The challenge of dry eye diagnosis. Clin Ophthalmol 2:31–55PubMedCrossRef Savini G, Prabhawasat P, Kojima T, Espana E (2008) The challenge of dry eye diagnosis. Clin Ophthalmol 2:31–55PubMedCrossRef
27.
Zurück zum Zitat Wang Y, Ogawa Y, Dogru M, Tatematsu Y, Uchino M, Kamoi M, Okada N, Okamoto S, Tsubota K (2010) Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye. Bone Marrow Transplant 45:1077–1083PubMedCrossRef Wang Y, Ogawa Y, Dogru M, Tatematsu Y, Uchino M, Kamoi M, Okada N, Okamoto S, Tsubota K (2010) Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye. Bone Marrow Transplant 45:1077–1083PubMedCrossRef
28.
Zurück zum Zitat Inamoto Y, Chai X, Kurland BF, Cutler C, Flowers ME, Palmer JM, Carpenter PA, Heffernan MJ, Jacobsohn D, Jagasia MH, Pidala J, Khera N, Vogelsang GB, Weisdorf D, Martin PJ, Pavletic SZ, Lee SJ, Chronic GVHD Consortium (2012) Validation of measurement scales in ocular graft-versus-host disease. Ophthalmology 119:487–493PubMedCrossRef Inamoto Y, Chai X, Kurland BF, Cutler C, Flowers ME, Palmer JM, Carpenter PA, Heffernan MJ, Jacobsohn D, Jagasia MH, Pidala J, Khera N, Vogelsang GB, Weisdorf D, Martin PJ, Pavletic SZ, Lee SJ, Chronic GVHD Consortium (2012) Validation of measurement scales in ocular graft-versus-host disease. Ophthalmology 119:487–493PubMedCrossRef
29.
Zurück zum Zitat Koc S, Leisenring W, Flowers ME, Anasetti C, Deeg HJ, Nash RA, Sanders JE, Witherspoon RP, Storb R, Appelbaum FR, Martin PJ (2002) Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone. Blood 100:48–51PubMedCrossRef Koc S, Leisenring W, Flowers ME, Anasetti C, Deeg HJ, Nash RA, Sanders JE, Witherspoon RP, Storb R, Appelbaum FR, Martin PJ (2002) Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone. Blood 100:48–51PubMedCrossRef
30.
Zurück zum Zitat Robinson MR, Lee SS, Rubin BI (2004) Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant 33:1031–1035PubMedCrossRef Robinson MR, Lee SS, Rubin BI (2004) Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant 33:1031–1035PubMedCrossRef
31.
Zurück zum Zitat Stevenson D, Tauber J, Reis BL (2000) Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial. The Cyclosporin A Phase 2 Study Group. Ophthalmology 107:967–974PubMedCrossRef Stevenson D, Tauber J, Reis BL (2000) Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease: a dose-ranging, randomized trial. The Cyclosporin A Phase 2 Study Group. Ophthalmology 107:967–974PubMedCrossRef
32.
Zurück zum Zitat Donnenfeld E, Pflugfelder SC (2009) Topical ophthalmic cyclosporine: pharmacology and clinical uses. Surv Ophthalmol 54:321–338PubMedCrossRef Donnenfeld E, Pflugfelder SC (2009) Topical ophthalmic cyclosporine: pharmacology and clinical uses. Surv Ophthalmol 54:321–338PubMedCrossRef
33.
Zurück zum Zitat Sall K, Stevenson OD, Mundorf TK, Reis BL (2000) Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 107:631–639PubMedCrossRef Sall K, Stevenson OD, Mundorf TK, Reis BL (2000) Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 107:631–639PubMedCrossRef
34.
Zurück zum Zitat Rao SN, Rao RD (2006) Efficacy of topical cyclosporine 0.05 % in the treatment of dry eye associated with graft versus host disease. Cornea 25:674–678PubMedCrossRef Rao SN, Rao RD (2006) Efficacy of topical cyclosporine 0.05 % in the treatment of dry eye associated with graft versus host disease. Cornea 25:674–678PubMedCrossRef
35.
Zurück zum Zitat Lelli GJ Jr, Musch DC, Gupta A (2006) Ophthalmic cyclosporine use in ocular GVHD. Cornea 25:635–638PubMedCrossRef Lelli GJ Jr, Musch DC, Gupta A (2006) Ophthalmic cyclosporine use in ocular GVHD. Cornea 25:635–638PubMedCrossRef
36.
Zurück zum Zitat Malta JB, Soong HK, Shtein RM, Musch DC, Rhoades W, Sugar A, Mian SI (2010) Treatment of ocular graft-versus-host disease with topical cyclosporine 0.05 %. Cornea 29:1392–1396PubMedCrossRef Malta JB, Soong HK, Shtein RM, Musch DC, Rhoades W, Sugar A, Mian SI (2010) Treatment of ocular graft-versus-host disease with topical cyclosporine 0.05 %. Cornea 29:1392–1396PubMedCrossRef
37.
Zurück zum Zitat Simpson D (2000) Drug therapy for acute graft-versus-host disease prophylaxis. J Hematother Stem Cell Res 9:317–325PubMedCrossRef Simpson D (2000) Drug therapy for acute graft-versus-host disease prophylaxis. J Hematother Stem Cell Res 9:317–325PubMedCrossRef
38.
Zurück zum Zitat Ogawa Y, Okamoto S, Kuwana M, Tsubota K (2001) Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids. Cornea 20:430–434PubMedCrossRef Ogawa Y, Okamoto S, Kuwana M, Tsubota K (2001) Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids. Cornea 20:430–434PubMedCrossRef
39.
Zurück zum Zitat Tam PM, Young AL, Cheng LL, Lam PT (2010) Topical 0.03 % tacrolimus ointment in the management of ocular surface inflammation in chronic GVHD. Bone Marrow Transplant 45:957–958PubMedCrossRef Tam PM, Young AL, Cheng LL, Lam PT (2010) Topical 0.03 % tacrolimus ointment in the management of ocular surface inflammation in chronic GVHD. Bone Marrow Transplant 45:957–958PubMedCrossRef
40.
Zurück zum Zitat Fox RI, Chan R, Michelson JB, Belmont JB, Michelson PE (1984) Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum 27:459–461PubMedCrossRef Fox RI, Chan R, Michelson JB, Belmont JB, Michelson PE (1984) Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum 27:459–461PubMedCrossRef
41.
Zurück zum Zitat Tsubota K, Goto E, Fujita H (1999) Treatment of dry eye by autologous serum application in Sjogren’s syndrome. Br J Ophthalmol 83:390–395PubMedCrossRef Tsubota K, Goto E, Fujita H (1999) Treatment of dry eye by autologous serum application in Sjogren’s syndrome. Br J Ophthalmol 83:390–395PubMedCrossRef
42.
Zurück zum Zitat Ogawa Y, Okamoto S, Mori T, Tsubota K (2003) Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant 31:579–583PubMedCrossRef Ogawa Y, Okamoto S, Mori T, Tsubota K (2003) Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant 31:579–583PubMedCrossRef
43.
Zurück zum Zitat Pflugfelder SC (2011) Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture. Am J Ophthalmol 152:900–909PubMedCrossRef Pflugfelder SC (2011) Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture. Am J Ophthalmol 152:900–909PubMedCrossRef
44.
Zurück zum Zitat Takahide K, Parker PM, Wu M, Hwang WY, Carpenter PA, Moravec C, Stehr B, Martin PJ, Rosenthal P, Forman SJ, Flowers ME (2007) Use of fluid-ventilated, gas-permeable scleral lens for management of severe keratoconjunctivitis sicca secondary to chronic graft-versus-host disease. Biol Blood Marrow Transplant 13:1016–1021PubMedCrossRef Takahide K, Parker PM, Wu M, Hwang WY, Carpenter PA, Moravec C, Stehr B, Martin PJ, Rosenthal P, Forman SJ, Flowers ME (2007) Use of fluid-ventilated, gas-permeable scleral lens for management of severe keratoconjunctivitis sicca secondary to chronic graft-versus-host disease. Biol Blood Marrow Transplant 13:1016–1021PubMedCrossRef
45.
Zurück zum Zitat Jacobs DS, Rosenthal P (2007) Boston scleral lens prosthetic device for treatment of severe dry eye in chronic graft-versus-host disease. Cornea 26:1195–1199PubMedCrossRef Jacobs DS, Rosenthal P (2007) Boston scleral lens prosthetic device for treatment of severe dry eye in chronic graft-versus-host disease. Cornea 26:1195–1199PubMedCrossRef
46.
Zurück zum Zitat Schornack MM, Baratz KH, Patel SV, Maguire LJ (2008) Jupiter scleral lenses in the management of chronic graft versus host disease. Eye Contact Lens 34:302–305PubMedCrossRef Schornack MM, Baratz KH, Patel SV, Maguire LJ (2008) Jupiter scleral lenses in the management of chronic graft versus host disease. Eye Contact Lens 34:302–305PubMedCrossRef
47.
Zurück zum Zitat Rowlings PA, Agahan AL, Perez-Simon JA, López A, Caballero D, Hernández E, Barrientos-Gutierrez T, Calonge M (2011) IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. Br J Haematol 97:855–864CrossRef Rowlings PA, Agahan AL, Perez-Simon JA, López A, Caballero D, Hernández E, Barrientos-Gutierrez T, Calonge M (2011) IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. Br J Haematol 97:855–864CrossRef
48.
Zurück zum Zitat Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18:295–304PubMedCrossRef Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED (1974) Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 18:295–304PubMedCrossRef
49.
Zurück zum Zitat Cahn JY, Klein JP, Lee SJ, Milpied N, Blaise D, Antin JH, Leblond V, Ifrah N, Jouet JP, Loberiza F, Ringden O, Barrett AJ, Horowitz MM, Socie G (2005) Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: a joint Societe Francaise de Greffe de Moelle et Therapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) prospective study. Blood 106:1495–1500PubMedCrossRef Cahn JY, Klein JP, Lee SJ, Milpied N, Blaise D, Antin JH, Leblond V, Ifrah N, Jouet JP, Loberiza F, Ringden O, Barrett AJ, Horowitz MM, Socie G (2005) Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: a joint Societe Francaise de Greffe de Moelle et Therapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) prospective study. Blood 106:1495–1500PubMedCrossRef
50.
Zurück zum Zitat Sales CS, Johnston LJ, Ta CN (2011) Long-term clinical course of dry eye in patients with chronic graft-versus-host disease referred for eye examination. Cornea 30:143–149PubMedCrossRef Sales CS, Johnston LJ, Ta CN (2011) Long-term clinical course of dry eye in patients with chronic graft-versus-host disease referred for eye examination. Cornea 30:143–149PubMedCrossRef
51.
Zurück zum Zitat Parra-Colin P, Agahan AL, Perez-Simon JA, Lopez A, Caballero D, Hernandez E, Barrientos-Gutierrez T, Calonge M (2011) Dry eye disease in chronic graft-versus-host disease: results from a Spanish retrospective cohort study. Transplant Proc 43:1934–1938PubMedCrossRef Parra-Colin P, Agahan AL, Perez-Simon JA, Lopez A, Caballero D, Hernandez E, Barrientos-Gutierrez T, Calonge M (2011) Dry eye disease in chronic graft-versus-host disease: results from a Spanish retrospective cohort study. Transplant Proc 43:1934–1938PubMedCrossRef
Metadaten
Titel
Graft versus host disease: clinical evaluation, diagnosis and management
verfasst von
Edgar M. Espana
Sejal Shah
Marcony R. Santhiago
Arun D. Singh
Publikationsdatum
01.05.2013
Verlag
Springer-Verlag
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 5/2013
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-013-2301-z

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