Skip to main content
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 10/2014

01.10.2014 | Retinal Disorders

Foveola nonpeeling internal limiting membrane surgery to prevent inner retinal damages in early stage 2 idiopathic macula hole

verfasst von: Tzyy-Chang Ho, Chung-May Yang, Jen-Shang Huang, Chang-Hao Yang, Muh-Shy Chen

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2014

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The purpose of this study was to investigate and present the results of a new vitrectomy technique to preserve the foveolar internal limiting membrane (ILM) during ILM peeling in early stage 2 macular holes (MH).

Methods

The medical records of 28 consecutive patients (28 eyes) with early stage 2 MH were retrospectively reviewed and randomly divided into two groups by the extent of ILM peeing. Group 1: foveolar ILM nonpeeling group (14 eyes), and group 2: total peeling of foveal ILM group (14 eyes). A donut-shaped ILM was peeled off, leaving a 400-μm-diameter ILM over foveola in group 1.

Results

Smooth and symmetric umbo foveolar contour was restored without inner retinal dimpling in all eyes in group 1, but not in group 2. The final vision was better in group 1 (P = 0.011). All eyes in group 1 (100 %) and seven of 14 eyes in group 2 (50 %)regained the inner segment/outer segment (IS/OS) line. Restoration of the umbo light reflex was found in 12 of 14 eyes in group 1 (86 %) but none in group 2 (0 %).

Conclusions

Nonpeeling of the foveolar ILM in early stage 2 idiopathic MH surgery prevented inner retinal damages, restored umbo light reflex, achieved better foveolar microstructures, and led to better final visual acuity.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Mester V, Kuhn F (2000) Internal limiting membrane removal in the management of full-thickness macular holes. Am J Ophthalmol 129:769–777PubMedCrossRef Mester V, Kuhn F (2000) Internal limiting membrane removal in the management of full-thickness macular holes. Am J Ophthalmol 129:769–777PubMedCrossRef
2.
Zurück zum Zitat Funata M, Wendel RT, de la Cruz Z et al (1992) Clinicopathologic study of bilateral macular holes treated with pars plana vitrectomy and gas tamponade. Retina 12:289–298PubMedCrossRef Funata M, Wendel RT, de la Cruz Z et al (1992) Clinicopathologic study of bilateral macular holes treated with pars plana vitrectomy and gas tamponade. Retina 12:289–298PubMedCrossRef
3.
Zurück zum Zitat Nakamura T, Murata T, Hisatomi T et al (2003) Ultrastructure of the vitreoretinal interface following the removal of the internal limiting membrane using indocyanine green. Curr Eye Res 27:395–399PubMedCrossRef Nakamura T, Murata T, Hisatomi T et al (2003) Ultrastructure of the vitreoretinal interface following the removal of the internal limiting membrane using indocyanine green. Curr Eye Res 27:395–399PubMedCrossRef
4.
Zurück zum Zitat Terasaki H, Miyake Y, Nomura R et al (2001) Focal macular ERGs in eyes after removal of macular ILM during macular hole surgery. Invest Ophthalmol Vis Sci 42:229–234PubMed Terasaki H, Miyake Y, Nomura R et al (2001) Focal macular ERGs in eyes after removal of macular ILM during macular hole surgery. Invest Ophthalmol Vis Sci 42:229–234PubMed
5.
Zurück zum Zitat Alkabes M, Salinas C, Vitale L et al (2011) En face optical coherence tomography of inner retinal defect after internal limiting membrane peeling for idiopathic macular hole. Invest Ophthalmol Vis Sci 52(11):8349–8355PubMedCrossRef Alkabes M, Salinas C, Vitale L et al (2011) En face optical coherence tomography of inner retinal defect after internal limiting membrane peeling for idiopathic macular hole. Invest Ophthalmol Vis Sci 52(11):8349–8355PubMedCrossRef
6.
Zurück zum Zitat Haritoglou C, Gandorfer A, Kampik A (2006) NFL appearance after peeling. Ophthalmology 113:1690PubMedCrossRef Haritoglou C, Gandorfer A, Kampik A (2006) NFL appearance after peeling. Ophthalmology 113:1690PubMedCrossRef
7.
Zurück zum Zitat Christensen UC, Kroyer K, Sander B et al (2009) Value of internal limiting membrane peeling in surgery idiopathic macular hole stage 2 and 3: a randomized clinical trial. Br J Ophthalmol 93:1005–1012PubMedCrossRef Christensen UC, Kroyer K, Sander B et al (2009) Value of internal limiting membrane peeling in surgery idiopathic macular hole stage 2 and 3: a randomized clinical trial. Br J Ophthalmol 93:1005–1012PubMedCrossRef
8.
Zurück zum Zitat Spaide RF (2012) “Dissociated optic nerve fiber layer appearance” after internal limiting membrane removal is inner retinal dimpling. Retina DOI:101097/IAE.0b013e3182671191 pg. 1719-1726 Spaide RF (2012) “Dissociated optic nerve fiber layer appearance” after internal limiting membrane removal is inner retinal dimpling. Retina DOI:101097/IAE.0b013e3182671191 pg. 1719-1726
9.
Zurück zum Zitat Kim JH, Kang SW, Park DY et al (2012) Asymmetric elongation of foveal tissue after macular hole surgery and its impact on metamorphopsia. Ophthalmology 119:2133–2140PubMedCrossRef Kim JH, Kang SW, Park DY et al (2012) Asymmetric elongation of foveal tissue after macular hole surgery and its impact on metamorphopsia. Ophthalmology 119:2133–2140PubMedCrossRef
10.
Zurück zum Zitat Baba Y, Yamamoto S, Kimoto R et al (2012) Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole. Eye advance online publication 17 August 2012;doi:10.1038/eye.2012.170 Baba Y, Yamamoto S, Kimoto R et al (2012) Reduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole. Eye advance online publication 17 August 2012;doi:10.​1038/​eye.​2012.​170
12.
Zurück zum Zitat Pilli S, Zawadzki RJ, Werner JS et al (2012) Visual outcome correlates with inner macular volume in eyes with surgically closed macular hole. Retina 32(10):2085–2095PubMedCrossRefPubMedCentral Pilli S, Zawadzki RJ, Werner JS et al (2012) Visual outcome correlates with inner macular volume in eyes with surgically closed macular hole. Retina 32(10):2085–2095PubMedCrossRefPubMedCentral
13.
Zurück zum Zitat Gass JDM (1988) Idiopathic senile macular hole: its early stages and pathogenesis. Arch Ophthalmol 106:629–639PubMedCrossRef Gass JDM (1988) Idiopathic senile macular hole: its early stages and pathogenesis. Arch Ophthalmol 106:629–639PubMedCrossRef
14.
Zurück zum Zitat Sjaarda RN, Thompson J (2006) Macular hole. In: Retina 4th ed. Ryan SJ, ed.: Mosby-Elsevier pg. 2527 Sjaarda RN, Thompson J (2006) Macular hole. In: Retina 4th ed. Ryan SJ, ed.: Mosby-Elsevier pg. 2527
15.
Zurück zum Zitat Tadayoni R, Gaudric A, Haouchine B et al (2006) Relationship between macular hole size and the potential benefit of internal limiting membrane peeling. Br J Ophthalmol 90:1239–1241PubMedCrossRefPubMedCentral Tadayoni R, Gaudric A, Haouchine B et al (2006) Relationship between macular hole size and the potential benefit of internal limiting membrane peeling. Br J Ophthalmol 90:1239–1241PubMedCrossRefPubMedCentral
16.
Zurück zum Zitat Ho TC, Chen MS, Hung JS et al (2012) Foveola nonpeeling technique in internal limiting membrane peeling of myopic foveoschisis surgery. Retina 32(3):631–634PubMed Ho TC, Chen MS, Hung JS et al (2012) Foveola nonpeeling technique in internal limiting membrane peeling of myopic foveoschisis surgery. Retina 32(3):631–634PubMed
17.
Zurück zum Zitat Shimada N, Sugamoto Y, Ogawa M et al (2012) Fovea-sparing internal limiting membrane peeling for myopic traction maculopathy. Am J Ophthalmol 154:693–701PubMedCrossRef Shimada N, Sugamoto Y, Ogawa M et al (2012) Fovea-sparing internal limiting membrane peeling for myopic traction maculopathy. Am J Ophthalmol 154:693–701PubMedCrossRef
18.
Zurück zum Zitat Wakabayashi T, Oshima Y, Fujimoto H et al (2009) Foveal microstructure and visual acuity after retinal detachment repair. Ophthalmology 116(3):519–528PubMedCrossRef Wakabayashi T, Oshima Y, Fujimoto H et al (2009) Foveal microstructure and visual acuity after retinal detachment repair. Ophthalmology 116(3):519–528PubMedCrossRef
19.
Zurück zum Zitat Wakabayashi T, Fujiwara M, Sakaguchi H et al (2010) Foveal microstructure and visual acuity in surgically closed macular holes: spectral-domain optical coherence tomographic analysis. Ophthalmology 117(9):1815–1824PubMedCrossRef Wakabayashi T, Fujiwara M, Sakaguchi H et al (2010) Foveal microstructure and visual acuity in surgically closed macular holes: spectral-domain optical coherence tomographic analysis. Ophthalmology 117(9):1815–1824PubMedCrossRef
20.
Zurück zum Zitat Lois N, Norrie J, Vale L et al (2011) Internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole: a pragmatic randomized controlled trial. Invest Ophthalmol Vis Sci 52(3):1586–1592PubMedCrossRef Lois N, Norrie J, Vale L et al (2011) Internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole: a pragmatic randomized controlled trial. Invest Ophthalmol Vis Sci 52(3):1586–1592PubMedCrossRef
21.
Zurück zum Zitat Chan P, Hoang QV, Chang S (2012) Frequency and Significance of Vitreoretinal Interface Remodeling after Repair of Idiopathic Macular Holes ARVO abstract poster #: A248 Chan P, Hoang QV, Chang S (2012) Frequency and Significance of Vitreoretinal Interface Remodeling after Repair of Idiopathic Macular Holes ARVO abstract poster #: A248
22.
Zurück zum Zitat Chang S, Gregory-Roberts E, Park S et al (2013) Double peeling during vitrectomy for macular pucker. The Charles L. Schepens Lecture. JAMA Ophthalmol 131(4):525–530PubMedCrossRef Chang S, Gregory-Roberts E, Park S et al (2013) Double peeling during vitrectomy for macular pucker. The Charles L. Schepens Lecture. JAMA Ophthalmol 131(4):525–530PubMedCrossRef
23.
Zurück zum Zitat Yoshikawa M, Murakami T, Nishijima K et al (2013) Macular migration toward the optic disc after inner limiting membrane peeling for diabetic macular edema. Invest Ophthalmol Vis Sci 54:629–635PubMedCrossRef Yoshikawa M, Murakami T, Nishijima K et al (2013) Macular migration toward the optic disc after inner limiting membrane peeling for diabetic macular edema. Invest Ophthalmol Vis Sci 54:629–635PubMedCrossRef
24.
Zurück zum Zitat Gaudric A, Tadayoni R. (2013) Macular hole. In: Retina 5th ed. Ryan SJ. P.1962-1978 Gaudric A, Tadayoni R. (2013) Macular hole. In: Retina 5th ed. Ryan SJ. P.1962-1978
25.
Zurück zum Zitat Franze K, Grosche J, Skatchkov SN et al (2007) Müller cells are living optical fibers in the vertebrate retina. Proc Natl Acad Sci U S A 104(20):8287–8292PubMedCrossRefPubMedCentral Franze K, Grosche J, Skatchkov SN et al (2007) Müller cells are living optical fibers in the vertebrate retina. Proc Natl Acad Sci U S A 104(20):8287–8292PubMedCrossRefPubMedCentral
26.
Zurück zum Zitat Mitamura Y, Ohtsuka K (2005) Relationship of dissociated optic nerve fiber layer appearance to internal limiting membrane peeling. Ophthalmology 112:1766–1770PubMedCrossRef Mitamura Y, Ohtsuka K (2005) Relationship of dissociated optic nerve fiber layer appearance to internal limiting membrane peeling. Ophthalmology 112:1766–1770PubMedCrossRef
27.
Zurück zum Zitat Ito Y, Terasaki H, Takahashi A et al (2005) Dissociated optic nerve fiber layer appearance after internal limiting membrane peeling for idiopathic macular holes. Ophthalmology 112:1415–1420PubMedCrossRef Ito Y, Terasaki H, Takahashi A et al (2005) Dissociated optic nerve fiber layer appearance after internal limiting membrane peeling for idiopathic macular holes. Ophthalmology 112:1415–1420PubMedCrossRef
28.
Zurück zum Zitat Nukada K, Hangai M, Ooto S et al (2013) Tomographic features of macula after successful macular hole surgery. Invest Ophthalmol Vis Sci Published online as manuscript iovs 12-10838 Nukada K, Hangai M, Ooto S et al (2013) Tomographic features of macula after successful macular hole surgery. Invest Ophthalmol Vis Sci Published online as manuscript iovs 12-10838
29.
Zurück zum Zitat DeCroos FC, Toth CA, Folgar FA et al (2012) Characterisation of vitreoretinal interface disorders using OCT in the interventional phase 3 trials of Ocriplasmin. Invest Ophthalmol Vis Sci 53(10):6504–6511PubMedCrossRef DeCroos FC, Toth CA, Folgar FA et al (2012) Characterisation of vitreoretinal interface disorders using OCT in the interventional phase 3 trials of Ocriplasmin. Invest Ophthalmol Vis Sci 53(10):6504–6511PubMedCrossRef
30.
Zurück zum Zitat Tsui I, Pan CK, Rahimy E, Schwartz SD. (2012) Ocriplasmin for Vitreoretinal Diseases. J Biomed Biotechnol Article ID 354979, 6 pages doi:10.1155/2012/354979 Tsui I, Pan CK, Rahimy E, Schwartz SD. (2012) Ocriplasmin for Vitreoretinal Diseases. J Biomed Biotechnol Article ID 354979, 6 pages doi:10.​1155/​2012/​354979
31.
Zurück zum Zitat Folgar FA, Toth CA, DeCroos FC et al (2012) Assessment of retinal morphology with spectral and time domain OCT in the phase III trials of enzymatic vitreolysis. Invest Ophthalmol Vis Sci 53(11):7395–7401PubMedCrossRef Folgar FA, Toth CA, DeCroos FC et al (2012) Assessment of retinal morphology with spectral and time domain OCT in the phase III trials of enzymatic vitreolysis. Invest Ophthalmol Vis Sci 53(11):7395–7401PubMedCrossRef
32.
Zurück zum Zitat Schneider EW, Johnson MW (2011) Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review. Clin Ophthalmol 5:1151–1165PubMedCrossRefPubMedCentral Schneider EW, Johnson MW (2011) Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review. Clin Ophthalmol 5:1151–1165PubMedCrossRefPubMedCentral
33.
Zurück zum Zitat Gandorfer A, Rohleder M, Sethi C et al (2004) Posterior vitreous detachment induced by microplasmin. Invest Ophthalmol Vis Sci 45(2):641–647PubMedCrossRef Gandorfer A, Rohleder M, Sethi C et al (2004) Posterior vitreous detachment induced by microplasmin. Invest Ophthalmol Vis Sci 45(2):641–647PubMedCrossRef
34.
Zurück zum Zitat Sakuma T, Tanaka M, Mizota A et al (2005) Safety of in vivo pharmacologic vitreolysis with recombinant microplasmin in rabbit eyes. Invest Ophthalmol Vis Sci 46(9):3295–3299PubMedCrossRef Sakuma T, Tanaka M, Mizota A et al (2005) Safety of in vivo pharmacologic vitreolysis with recombinant microplasmin in rabbit eyes. Invest Ophthalmol Vis Sci 46(9):3295–3299PubMedCrossRef
35.
Zurück zum Zitat De Smet MD, Valmaggia C, Zarranz-Ventura J et al (2009) Microplasmin: ex vivo characterization of its activity in porcine vitreous. Invest Ophthalmol Vis Sci 50(2):814–819PubMedCrossRef De Smet MD, Valmaggia C, Zarranz-Ventura J et al (2009) Microplasmin: ex vivo characterization of its activity in porcine vitreous. Invest Ophthalmol Vis Sci 50(2):814–819PubMedCrossRef
36.
Zurück zum Zitat Stalmans P, Benz MS, Gandorfer A et al (2012) Enzymatic vitreolysis with Ocriplasmin for vitreomacular traction and macular holes. N Engl J Med 367(7):606–615PubMedCrossRef Stalmans P, Benz MS, Gandorfer A et al (2012) Enzymatic vitreolysis with Ocriplasmin for vitreomacular traction and macular holes. N Engl J Med 367(7):606–615PubMedCrossRef
37.
Zurück zum Zitat Tognetto D, Grandin R, Sanguinetti G et al (2006) Internal limiting membrane removal during macular hole surgery: results of a multicenter retrospective study. Ophthalmology 113:1401–1410PubMedCrossRef Tognetto D, Grandin R, Sanguinetti G et al (2006) Internal limiting membrane removal during macular hole surgery: results of a multicenter retrospective study. Ophthalmology 113:1401–1410PubMedCrossRef
Metadaten
Titel
Foveola nonpeeling internal limiting membrane surgery to prevent inner retinal damages in early stage 2 idiopathic macula hole
verfasst von
Tzyy-Chang Ho
Chung-May Yang
Jen-Shang Huang
Chang-Hao Yang
Muh-Shy Chen
Publikationsdatum
01.10.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2014
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-014-2613-7

Weitere Artikel der Ausgabe 10/2014

Graefe's Archive for Clinical and Experimental Ophthalmology 10/2014 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.