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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 8/2014

01.08.2014 | Neurophthalmology

A pilot study of the effect of intravenous erythropoetin on improvement of visual function in patients with recent indirect traumatic optic neuropathy

verfasst von: Morteza Entezari, Manuchehr Esmaeili, Mehdi Yaseri

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 8/2014

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Abstract

Background

To evaluate the efficacy of intravenous erythropoietin (EPO) on improvement of visual function and color vision in patients with recent indirect traumatic optic neuropathy (TON).

Methods

In a case series, 18 eyes of 18 patients with diagnosis of indirect TON with duration of less than 2 weeks underwent 20,000 IU intravenous EPO injections daily for 3 days. Best corrected visual acuity (BCVA) and color vision were checked by Ishihara test before, 1, and 3 months after injections. BCVA and color vision were compared before, 1, and 3 months after injections.

Results

The mean BCVA improved from a baseline of 2.21 ± 0.97 to 1.48 ± 1.29 and 1.31 ± 1.27 log MAR at months 1 and 3, respectively. The differences were statistically significant (P = 0.001, P < 0.001). Color vision was changed from a baseline 2.24 ± 4.29 to 2.94 ± 4.64 and 3.41 ± 5.09 plates at months 1 and 3, respectively. We observed some qualitative improvement that was, however, statistically insignificant at the time of evaluation. (P = 0.063, P = 0.068).

Conclusion

This case series showed noticeable effect of EPO on improvement of visual function in patients with recent indirect TON.
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Metadaten
Titel
A pilot study of the effect of intravenous erythropoetin on improvement of visual function in patients with recent indirect traumatic optic neuropathy
verfasst von
Morteza Entezari
Manuchehr Esmaeili
Mehdi Yaseri
Publikationsdatum
01.08.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 8/2014
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-014-2691-6

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