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International Archives of Occupational and Environmental Health

Erschienen in:

01.02.2005 | Review

Gases and organic solvents in urine as biomarkers of occupational exposure: a review

verfasst von: M. Imbriani, S. Ghittori

Erschienen in: International Archives of Occupational and Environmental Health | Ausgabe 1/2005

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Abstract

A brief review of urine analysis in studies of occupational exposure to volatile organic compounds and gases is provided. Analysis of exhaled breath for volatile compounds does not have a long history in occupational medicine. A number of studies has been undertaken since the 1980s, and the methods are well enough accepted to be put forward as biological equivalents of threshold limit values (TLVs) for some volatile organic compounds (VOCs) such as acetone; methanol; methyl ethyl ketone (MEK); methyl isobutyl ketone (MIBK); tetrahydrofurane; dichloromethane. In the last 20 years many scientific articles have shown that the urinary concentrations of unchanged solvents are correlated with environmental exposure and could be used for biological monitoring. The use of urine analysis of unchanged solvents in occupational applications is not yet widespread. Nonetheless, in the short time since its application, a number of important discoveries has been made, and the future appears bright for this branch of analysis. In this paper, the basic concepts and methodology of urine analysis are briefly presented with a critical revision of the literature on this matter. The excretion mechanisms of organic solvents in urine are discussed, with regard to biological variability, and the future directions of research are described.

Accorsi A, Barbieri A, Raffi GB, Violante FS (2001) Biomonitoring of exposure to nitrous oxide, sevoflurane, isoflurane and halothane by automated GC/MS headspace urinalysis. Int Arch Occup Environ Health 74:541–548PubMed

Accorsi A, Valenti S, Barbieri A, Raffi GB, Violante FS (2003) Proposal for single and mixture biological exposure limits for sevoflurane and nitrous oxide al low occupational exposure levels. Int Arch Occup Environ Health 76:129–136PubMed

Alessio A, Zadra P, Negri S, Maestri L, Imberti R, Ghittori S, Imbriani M, Cavalleri A (2003) Biological monitoring of occupational exposure to desflurane. G Ital Med Lav Ergon 25:137–141

American Conference of Governmental Industrial Hygienists (ACGIH) (1977) TLVs and BEIs based on the documentation of the threshold limit values for the chemical substances and physical agents and biological exposure indices. Cincinnati

American Conference of Governmental Industrial Hygienists (ACGIH) (2003) TLVs and BEIs based on the documentation of the threshold limit values for the chemical substances and physical agents and biological exposure indices. Cincinnati

Apostoli P, Gelmi M, Alessio L, Turano A (1996) Interferences of urinary tract infection in the measurement of urinary nitrous oxide. Occup Environ Med 53:591–594PubMed

Asakawa F, Jitsunari F, Choi J, Suna S, Takaneda N, Kitamado T (1999) Method for analyzing urinary toluene and xylene by solid-phase microextraction (SPME), and its application to workers using organic solvents. Bull Environ Contam Toxicol 62:109–116CrossRefPubMed

Brugnone F, Perbellini L, Giuliari C, Cerpelloni M, Soave M (1994) Blood and urine concentrations of chemical pollutants in the general population. Med Lav 85:370–389PubMed

Brugnone F, Perbellini L, Cerpelloni M, Soave C, Cecco A, Giuliari C (1995) Nitrous oxide in blood and urine of operating theatre personnel and the general population. Int Arch Occup Environ Health 68:22–26PubMed

Chuwers P, Osterloh J, Kelly T, D’Alessandro A, Quinlan P, Becker C (1995) Neurobehavioral effects of low-level methanol vapor exposure in healthy human volunteers. Environ Res 71:141–150CrossRefPubMed

De Oliveira DP, Pereira Bastos de Siqueira ME (2004) Reference values of urinary acetone in a Brazilian population and influence of gender, age, smoking and drinking. Med Lav 95:32–38PubMed

Deutsche Forschungsgemeinschaft (DFG) MAK-und BAT-Werte-List (2002) Senatskommission zur Prufung gesundheitsschadlicher Arbeitssoffe. 38th edn. VCH, Weinheim

DiVincenzo, Yanno FJ, Astill BD (1972) Human and canine exposure to methylene chloride vapor. Am Ind Hyg Assoc J 33:125–135

Dolara P, Caderni G, Lodovici M, Santoni G, Salvadori M, Baroni A (1984) Determination of styrene in the urine of workers manufacturing polystyrene plastics. Ann Occup Hyg 28:195–199PubMed

Droz PO (1990) Pharmacokinetic modelling of styrene exposure, in Esposizione a Stirene. Rischi, Tossicitàe Criteri per il Monitoraggio Biologico. In: Capodaglio E, Manzo L (eds) Fondazione Clinica del Lavoro. Convegno Internazionale, Pavia, pp 19–29

Droz PO, Wu MM, Cumberland WG, Berode M (1989a) Variability in biological monitoring of solvent exposure. I. Development of a population physiological model. Br J Ind Med Jul 46:447–460

Droz PO, Wu MM, Cumberland WG (1989b) Variability in biological monitoring of organic solvent exposure. II. Application of a population physiological model. Br J Ind Med 46:547–558PubMed

Franzblau (1997) Evaluation of methanol and formate in urine as biological exposure indices of methanol exposure. Appl Occup Environ Hyg 12:367–374

Fujino A, Satoh T, Takebayashi T, Nakashima H, Sakurai H, Higashi T, Matumura H, Minaguchi H, Kawai T (1992) Biological monitoring of workers exposed to acetone in acetate fibre plants. Br J Ind Med 49:654–657PubMed

Furuki K, Ukai H, Okamoto S, Takada S, Kawai T, Miyama Y, Mitsuyoshi K, Zhang ZW, Higashikawa K, Ikeda M (2000) Monitoring of occupational exposure to tetrachloroethene by analysis for unmetabolized tetrachloroethene in blood and urine in comparison with urinalysis for trichloroacetic acid. Int Arch Occup Environ Health 73:221–227CrossRefPubMed

Fustinoni S, Buratti M, Giampiccolo R, Brambilla G, Foa V, Colombi A (2000). Comparison between blood and urinary toluene as biomarkers of exposure to toluene. Int Arch Occup Environ Health 73:389–396CrossRefPubMed

Ghittori S, Imbriani M, Pezzagno G, Capodaglio E (1987) The urinary concentration of solvents as a biological indicator of exposure: proposal for the biological equivalent exposure limit for nine solvents. Am Ind Hyg Assoc J 48:786–790PubMed

Ghittori S, Fiorentino ML, Maestri L, Cordioli G, Imbriani M (1993a) Urinary excretion of unmetabolized benzene as an indicator of benzene exposure. J Toxicol Environ Health 38:233–243PubMed

Ghittori S, Marraccini P, Franco G, Imbriani M (1993b) Methylene chloride exposure in industrial workers. Am Ind Hyg Assoc J 54:27–31PubMed

Ghittori S, Saretto G, Imbriani M (1994) Biological monitoring of workers exposed to carbon tetrachloride vapors. Appl Occup Hyg 9:353–357

Ghittori S, Maestri L, Maraccini P, Imbriani M (1996) Acetone in urine as biological index of occupational exposure to isopropyl alcohol. Ind Health 34:409–414PubMed

Ghittori S, Maestri L, Contardi I, Zadra P, Marraccini P, Imbriani M (1998) Biological monitoring of workers exposed to carbon disulfide (CS₂) in a viscose rayon fibers factory. Am J Ind Med 33:478–484CrossRefPubMed

Ghittori S, Alessio A, Negri S, Maestri L, Zadra P, Imbriani M (2004) A field method for sampling toluene in end-exhaled air, as a biomarker of occupational exposure: correlation with other exposure indices. Ind Health (in press)

Gobba F, Galassi C, Ghittori S, Imbriani M, Pugliese F, Cavalleri A (1993) Urinary styrene in the biological monitoring of styrene exposure. Scand J Work Environ Health 19:175–182PubMed

Gobba F, Ghittori S, Imbriani M, Maestri L, Capodaglio E, Cavalleri A (1997a) The urinary excretion of solvents and gases for the biological monitoring of occupational exposure: a review. Sci Total Environ 199:3–12CrossRefPubMed

Gobba F, Rosa P, Ghittori S, Imbriani M, Ferrari G, Cavalleri A (1997b) Environmental and biological monitoring of occupational exposure to perchloroethylene in dry cleaning shops. Med Lav 88:24–36PubMed

Gobba F, Righi E, Fantuzzi G, Roccato L, Predieri G, Aggazzotti G (2003) Perchloroethylene in alveolar air, blood, and urine as biologic indices of low level exposure. J Occup Environ Med 45:1152–1156CrossRefPubMed

Heinrich R, Angerer J (1982) Occupational chronic exposure to organic solvents. X. Biological monitoring parameters for methanol exposure. Int Arch Occup Environ Health 50:341–349PubMed

Henderson KA, Matthews IP, Adisesh A, Hutchings AD (2003) Occupational exposure of midwives to nitrous oxide on delivery suites. Occup Environ Med 60:958–961CrossRefPubMed

Houthuijs D, Remijn B, Willems H, Boleij J, Biersteker K (1982) Biological monitoring of acrylonitrile exposure. Am J Ind Med 3:313–320PubMed

Hung IF, Lee SA, Chen RK (1998) Simultaneous determination of benzene, toluene, ethylbenzene, and xylenes in urine by thermal desorption-gas chromatography. J Chromatogr B Biomed Sci Appl 706:352–357CrossRefPubMed

IARC (1999) Monographs on the evaluation of the carcinogenic risk of chemicals to man. International Agency for Research on Cancer. World Health Organization, Geneva, 71:1030

Ikeda M (1999) Solvents in urine as exposure markers. Toxicol Lett

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E (1984) n-Hexane urine elimination and weighted exposure concentration. Int Arch Occup Environ Health 55:33–41PubMed

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E (1985) Urine/air partition coefficients for some industrially important substances. G Ital Med Lav 7:133–140PubMed

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E (1987) Urinary elimination of xylene in experimental and occupational exposure. Med Lav 78:239–249PubMed

Imbriani M, Ghittori S, Pezzagno G, Huang J, Capodaglio E (1988a) 1,1,1-Trichloroethane (methyl chloroform) in urine as biological index of exposure. Am J Ind Med 13:211–222PubMed

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E (1988b) Urinary excretion of tetrachloroethylene (perchloroethylene) in experimental and occupational exposure. Arch Environ Health 43:292–298PubMed

Imbriani M, Ghittori S, Pezzagno G (1988c) Nitrous oxide (N₂O) in urine as biological index of exposure in operating room personnel. Appl Ind Hyg 3:223–227

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E (1989) Methyl ethyl ketone (MEK) in urine as biological index of exposure. G Ital Med Lav 11:255–261PubMed

Imbriani M, Gobba F, Ghittori S, Di Rico R, Piscitelli M, Capodaglio E, Cavalleri A (1990) Biological monitoring of occupational exposure to styrene, comparison between urinary mandelic acid concentration and styrene concentration in urine and blood. Appl Ind Hyg 5:223–228

Imbriani M, Ghittori S, Pezzagno G, Capodaglio E (1995) Anesthetic in urine as biological index of exposure in operating-room personnel. J Toxicol Environ Health 46:249–260PubMed

Imbriani M, Ghittori S, Pezzagno G (1998) The biological monitoring of inhalation anaesthetics. G Ital Med Lav Ergon 20:44–49PubMed

Imbriani M, Niu Q, Negri S, Ghittori S (2001) Trichloroethylene in urine as biological exposure index. Ind Health 39:225–230PubMed

Jang JY, Droz PO (1997) Ethnic differences in biological monitoring of several organic solvents. II. A simulation study with a physiologically based pharmacokinetic model. Int Arch Occup Environ Health 70:41–50CrossRefPubMed

Jang JY, Kang SK, Chung HK (1993) Biological exposure indices of organic solvents for Korean workers. Int Arch Occup Environ Health 65:S219–222CrossRefPubMed

Jang JY, Droz PO, Berode M (1997) Ethnic differences in biological monitoring of several organic solvents. I. Human exposure experiment. Int Arch Occup Environ Health 69:343–349CrossRefPubMed

Japan Society for Occupational Health (2003) Recommendation of occupational exposure. J Occup Health 45:254–269PubMed

Kawai T, Yasugi T, Horiguchi S, Uchida Y, Iwami O, Iguchi H, Inoue O, Watanabe T, Nakatsuka H, Ikeda M (1990a) Biological monitoring of occupational exposure to isopropyl alcohol vapor by urinalysis for acetone. Int Arch Occup Environ Health 62:409–413PubMed

Kawai T, Yasugi T, Uchida Y, Iwami O, Ikeda M (1990b) Urinary excretion of unmetabolized acetone as an indicator of occupational exposure to acetone. Int Arch Occup Environ Health 62:165–169PubMed

Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Hirase Y, Uchida Y, Ikeda M (1991) Methanol in urine as a biological indicator of occupational exposure to methanol vapor. Int Arch Occup Environ Health 63:311–318PubMed

Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Morioka I, Miyashita K, Uchida Y, Ikeda M (1992a) Monitoring of workers exposed to a mixture of toluene, styrene and methanol vapours by means of diffusive air sampling, blood analysis and urinalysis. Int Arch Occup Environ Health 63:429–435PubMed

Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Iguchi H, Ikeda M (1992b) Curvi-linear relation between acetone in breathing zone air and acetone in urine among workers exposed to acetone vapor. Toxicol Lett 62:85–91CrossRefPubMed

Kawai T, Mizunuma K, Okada Y, Horiguchi S, Ikeda M (1996). Toluene itself as the best urinary marker of toluene exposure. Int Arch Occup Environ Health 68:289–297CrossRefPubMed

Kawai T, Okada Y, Odachi T, Horiguchi S, Zhang ZW, Moon CS, Furuki K, Ukai H, Inui S, Ikeda M (1997) Monitoring of occupational exposure to 1-butanol by diffusive sampling and urinalysis. Int Arch Occup Environ Health 69:266–272CrossRefPubMed

Kawai T, Zhang ZW, Takeuchi A, Miyama Y, Sakamoto K, Higashikawa K, Ikeda M (2003). Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels. Int Arch Occup Environ Health 76:17–23PubMed

Kivisto H, Pekari K, Peltonen K, Svinhufvud J, Veidebaum T, Sorsa M, Aitio A (1997) Biological monitoring of exposure to benzene in the production of benzene and in a cokery. Sci Total Environ 199:49–63CrossRefPubMed

Kok PW, Ong CN (1994) Blood and urinary benzene determined by headspace gas chromatography with photoionization detection: application in biological monitoring of low-level nonoccupational exposure. Int Arch Occup Environ Health 66:195–201PubMed

Kumagai S, Matsunaga I, Tabuchi T (1998) Effects of variation in exposure to airborne acetone and difference in work load on acetone concentrations in blood, urine, and exhaled air. Am Ind Hyg Assoc J 59:242–251PubMed

Lagorio S, Crebelli R, Ricciarello R, Conti L, Iavarone I, Zona A, Ghittori S, Carere A (1998) Methodological issues in biomonitoring of low level exposure to benzene. Occup Med (Lond) 48:497–504

Lareo AC, Perbellini L (1995) Biological monitoring of workers exposed to N-N-dimethylformamide. II. Dimethylformamide and its metabolites in urine of exposed workers. Int Arch Occup Environ Health 67:47–52PubMed

Liira J, Johanson G, Riihimaki V (1990) Dose-dependent kinetics of inhaled methylethylketone in man. Toxicol Lett 50:195–201CrossRefPubMed

Lof A, Johanson G (1998) Toxicokinetics of organic solvents: a review of modifying factors. Crit Rev Toxicol 28:571–650PubMed

Miyasaka M, Kumai M, Koizumi A, Watanabe T, Kurasako K, Sato K, Ikeda M (1982) Biological monitoring of occupational exposure to methyl ethyl ketone by means of urinalysis for methyl ethyl ketone itself. Int Arch Occup Environ Health 50:131–137PubMed

Mizunuma K, Yasugi T, Kawai T, Horiguchi S, Ikeda M (1993) Exposure–excretion relationship of styrene and acetone in factory workers: a comparison of a lipophilic solvent and a hydrophilic solvent. Arch Environ Contam Toxicol 25:129–133CrossRefPubMed

Mizunuma K, Kawai T, Horiguchi S, Ikeda M (1995) Urinary methylchloroform rather than urinary metabolites as an indicator of occupational exposure to methylchloroform. Int Arch Occup Environ Health 67:19–25PubMed

Monster AC, Kezic S, van de Gevel I, de Wolff FA (1993). Evaluation of biological monitoring parameters for occupational exposure to toluene. Int Arch Occup Environ Health 65:S159–S162CrossRefPubMed

Ogata M, Iwamoto T (1990) Enzymatic assay of formic acid and gas chromatography of methanol for urinary biological monitoring of exposure to methanol. Int Arch Occup Environ Health 62:227–232PubMed

Ogata M, Taguchi T, Hirota N, Shimida Y, Nakae S (1990) A database for biological monitoring of aromatic solvents. In: Fiserova-Bergerova V, Ogata M (eds) Biological monitoring of exposure to industrial chemicals. Proceedings of the USA-Japan cooperative seminar on biological monitoring. ACGIH, Cincinnati, pp 119–126

Ong CN, Chia SE, Phoon WH, Tan KT (1991a) Biological monitoring of occupational exposure to tetrahydrofuran. Br J Ind Med 48:616–621PubMed

Ong CN, Sia GL, Ong HY, Phoon WH, Tan KT (1991b) Biological monitoring of occupational exposure to methyl ethyl ketone. Int Arch Occup Environ Health 63:319–324PubMed

Ong CN, Kok PW, Ong HY, Shi CY, Lee BL, Phoon WH, Tan KT (1996) Biomarkers of exposure to low concentrations of benzene: a field assessment. Occup Environ Med 53:328–333PubMed

Passarelli MM, Paolielo MM, Matsuo T, Turin CA, Nascimento ES (1999) Methanol reference values in urine from inhabitants of Brazil. Sci Total Environ 243–244:349–352CrossRef

Pekary K, Nylander-French L, Pfaffli P, Sorsa M, Aitio A (1993) Biological monitoring of exposure to styrene—assessment of different approaches. J Occup Med Toxicol 2:115–126

Perbellini L, Ghittori S (1998) The biological monitoring of occupational exposures to solvents by using their urinary concentrations. Med Lav 89:375–386PubMed

Perbellini L, Brugnone F, Mozzo P, Cocheo V, Caretta D (1984) Methyl ethyl ketone exposure in industrial workers. Uptake and kinetics. Int Arch Occup Environ Health 54:73–81PubMed

Perbellini L, Ganzi A, Venturi G, Cerpelloni M, Brugnone F (1998) biological monitoring of acrylonitrile exposure. G Ital Med Lav Ergon 20:10–14PubMed

Perbellini L, Buratti M, Fiorentino ML, Fustinoni S, Pasini F, Magnaghi S (1999) Matrix interferences in the analysis of benzene in urine. J Chromatogr B 724:257–264

Pezzagno G, Ghittori S, Imbriani M, Capodaglio E (1982) The measurement of the solubility coefficients of aeriforms in the blood or other solvent liquids. I. The methods. G Ital Med Lav 4:251–261PubMed

Pezzagno G, Ghittori S, Imbriani M (1985a) Respiratory measurements of occupational exposure to industrial solvents. G Ital Med Lav Ergon 7:17–34

Pezzagno G, Ghittori S, Imbriani M, Capodaglio E (1985b) Urinary elimination of styrene in experimental and occupational exposure. Scand J Work Environ Health 11:371–379PubMed

Pezzagno G, Imbriani M, Ghittori S, Capodaglio E, Huang J (1986) Urinary elimination of acetone in experimental and occupational exposure. Scand J Work Environ Health 12:603–608PubMed

Pezzagno G, Imbriani M, Ghittori S, Capodaglio E (1988) Urinary concentration, environmental concentration and respiratory uptake of some solvents: effect of the workload. Am Ind Hyg Assoc J 49:546–552PubMed

Rosemberg J, Fiserova-Bergerova V, Lowry L (1989) Biological monitoring IV: measurements in urine. Appl Ind Hyg 4:F16–20

Sakai T, Morita Y, Wakui C (2002) Biological monitoring of workers exposed to DCM, using head-space gas chromatography. J Chromatogr B 778:245–250CrossRef

Sakurai H, Onodera M, Utsunomiya T, Minakuchi H, Iwai H, Matsumura H (1978) Health effects of acrylonitrile in acrylic fibre factories. Br J Ind Med 35:219–222

Satoh T, Omae K, Takebayashi T, Nakashima H, Higashi T, Sakurai H (1995) Acetone excretion into urine of workers exposed to acetone in acetate fiber plants. Int Arch Occup Environ Health 67:131–134PubMed

Satoh T, Omae K, Nakashima H, Takebayashi T, Matsumura H, Kawai T, Nakaza M, Sakurai H (1996) Relationship between acetone exposure concentration and health effects in acetate fiber plant workers. Int Arch Occup Environ Health 68:147–153CrossRefPubMed

Sedivec V, Mraz M, Flek J (1981) Biological monitoring of persons exposed to methanol vapours. Int Arch Occup Environ Health 48:257–271CrossRefPubMed

Skender L, Brcic I, Zuzul S (2002) Determination of benzene in urine by static headspace gas chromatography. Arh Hig Rada Toksikol 53:197–202PubMed

Sonander H, Stenqvist O, Nilsson K (1983) Urinary Nto trace amounts of nitrous oxide. Evaluation of urinary gas content monitoring in anaesthetic practO as a measure of biological exposure to nitrous oxide anaesthetic contamination. Ann Occup Hyg 27:73–77PubMed

Stevens MP, Walrand J, Buchet JP, Lauwerys R (1987) Evaluation dell’esposition à l’halotanne et au protoxide d’azote en salle d’operation par des mesures d’ambiance et des mesures biologiques. Cah Med Trav 34:41–46

Takeuchi A, Kawai T, Zhang ZW, Miyama Y, Sakamoto K, Higashikawa K, Ikeda H (2002) Toluene, xylenes and xylene isomers in urine as biological indicators of low-level exposure to each solvent: a comparative study. Int Arch Occup Environ Health 75:387–393CrossRefPubMed

Tolentino D, Zenari E, Dall’Olio M, Ruani G, Gelormini A, Mirone G (2003) Application of statistical models to estimate the correlation between urinary benzene as biological indicator of exposure and air concentrations determined by personal monitoring. AIHA J 64:625–629CrossRef

Trevisan A, Gori GP (1990) Biological monitoring of nitrous oxide exposure in surgical areas. Am J Ind Med 17:357–362PubMed

Ukai H, Okamoto S, Takada S, Inui S, Kawai T, Higashikawa K, Ikeda M (1998) Monitoring of occupational exposure to dichloromethane by diffuse vapor sampling and urinalysis. Int Arch Occup Environ Health 71:397–404CrossRefPubMed

Waidyanatha S, Rothman N, Fustinoni S, Smith MT, Hayes RB, Bechtold W, Dosemeci M, Guilan L, Yin S, Rappaport SM (2001) Urinary benzene as a biomarker of exposure among occupationally exposed and unexposed subjects. Carcinogenesis 22:279–286CrossRefPubMed

Wang G, Maranelli G, Perbellini L, Raineri E, Brugnone F (1994) Blood acetone concentration in “normal people” and in exposed workers 16 h after the end of the workshift. Int Arch Occup Environ Health 65:285–289CrossRefPubMed

Widmark DMP (1920) Studies in the acetone concentration in blood, urine and alveolar air: II. The passage of acetone and aceto-acetic acid into the urine. Biochemistry 14:364–378

Wigaeus E, Holm S, Astrand I (1981) Exposure to acetone. Uptake and elimination in man. Scand J Work Environ Health 7:84–94

Yoshikawa M, Kawamoto T, Murata K, Arashidani K, Katoh T, Kodama Y (1995) Biological monitoring of occupational exposure to methyl ethyl ketone in Japanese workers. Arch Environ Contam Toxicol 29:135–139PubMed

Titel: Gases and organic solvents in urine as biomarkers of occupational exposure: a review
verfasst von: M. Imbriani
S. Ghittori
Publikationsdatum: 01.02.2005
Verlag: Springer-Verlag
Erschienen in: International Archives of Occupational and Environmental Health / Ausgabe 1/2005
Print ISSN: 0340-0131
Elektronische ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-004-0544-z

Springer Medizin

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