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Erschienen in: European Journal of Applied Physiology 1-2/2004

01.10.2004 | Original Article

Control of erythropoiesis after high altitude acclimatization

verfasst von: Gustave Savourey, Jean-Claude Launay, Yves Besnard, Angélique Guinet, Cyprien Bourrilhon, Damien Cabane, Serge Martin, Jean-Pierre Caravel, Jean-Marc Péquignot, Jean-Marie Cottet-Emard

Erschienen in: European Journal of Applied Physiology | Ausgabe 1-2/2004

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Abstract

Erythropoiesis was studied in 11 subjects submitted to a 4-h hypoxia (HH) in a hypobaric chamber (4,500 m, barometric pressure 58.9 kPa) both before and after a 3-week sojourn in the Andes. On return to sea level, increased red blood cells (+3.27%), packed cell volume (+4.76%), haemoglobin (+6.55%) (P<0.05), and increased arterial partial pressure of oxygen (+8.56%), arterial oxygen saturation (+7.40%) and arterial oxygen blood content (CaO2) (+12.93%) at the end of HH (P<0.05) attested high altitude acclimatization. Reticulocytes increased during HH after the sojourn only (+36.8% vs +17.9%, P<0.01) indicating a probable higher reticulocyte release and/or production despite decreased serum erythropoietin (EPO) concentrations (−46%, P<0.01). Hormones (thyroid, catecholamines and cortisol), iron status (serum iron, ferritin, transferrin and haptoglobin) and renal function (creatinine, renal, osmolar and free-water clearances) did not significantly vary (except for lower thyroid stimulating hormone at sea level, P<0.01). Levels of 2,3-diphosphoglycerate (2,3-DPG) increased throughout HH on return (+14.7%, P<0.05) and an inverse linear relationship was found between 2,3-DPG and EPO at the end of HH after the sojourn only (r=−0.66, P<0.03). Inverse linear relationships were also found between CaO2 and EPO at the end of HH before (r=−0.63, P<0.05) and after the sojourn (r=−0.60, P=0.05) with identical slopes but different ordinates at the origin, suggesting that the sensitivity but not the gain of the EPO response to hypoxia was modified by altitude acclimatization. Higher 2,3-DPG levels could partly explain this decreased sensitivity of the EPO response to hypoxia. In conclusion, we show that altitude acclimatization modifies the control of erythropoiesis not only at sea level, but also during a subsequent hypoxia.
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Metadaten
Titel
Control of erythropoiesis after high altitude acclimatization
verfasst von
Gustave Savourey
Jean-Claude Launay
Yves Besnard
Angélique Guinet
Cyprien Bourrilhon
Damien Cabane
Serge Martin
Jean-Pierre Caravel
Jean-Marc Péquignot
Jean-Marie Cottet-Emard
Publikationsdatum
01.10.2004
Verlag
Springer-Verlag
Erschienen in
European Journal of Applied Physiology / Ausgabe 1-2/2004
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-004-1159-5

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