Skip to main content
Erschienen in: Langenbeck's Archives of Surgery 1/2017

03.08.2016 | ORIGINAL ARTICLE

Postoperative ileus: in search of an international consensus on definition, diagnosis, and treatment

verfasst von: Daniel Gero, Olivier Gié, Martin Hübner, Nicolas Demartines, Dieter Hahnloser

Erschienen in: Langenbeck's Archives of Surgery | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Postoperative ileus (POI) is a frequent complication after abdominal surgery; nonetheless, it remains poorly defined. Our aim was to achieve an international consensus among leading colorectal surgeons on definition, prevention, and treatment of POI.

Methods

Thirty-five experts from five continents participated in a three-round Delphi process. Round 1 contained open-ended questions on POI and postoperative nausea and vomiting (PONV). Round 2 included closed-ended questions. Round 3 measured agreement on a 5-point Likert scale. Consensus was defined when items were rated as agree or strongly agree by at least 70 % of the experts.

Results

Experts reached following consensus: POI is a temporary inhibition (86 %) of gastrointestinal motility after surgical intervention due to non-mechanical causes (89 %) and prevents sufficient oral intake (96 %). Abdominal distension/tenderness are the most relevant clinical signs (71 %). Nasogastric tube placement is not mandatory (78 %) but can be removed without previous clamping (81 %)/gastrointestinal contrast study (100 %). Preventive measures are recommended to decrease the risk of POI (96 %): narcotic sparing analgesia (89 %) and fluid optimization (74 %). Treatment of POI should include stimulation of ambulation (96 %) and stop of opioids (74 %). Total parenteral nutrition is recommended from the 7th day without sufficient oral intake (81 %). There was no consensus on the ranking of POI’s symptoms, on the imaging modality of choice for the diagnosis of POI, neither on the difference between POI and PONV.

Conclusions

This Delphi study achieved consensus on the definition, relevant clinical signs, prevention, treatment, and supportive care of POI. Areas of non-consensus were identified (necessity and modality of radiologic imaging to establish the diagnosis, difference between POI and PONV), giving opportunity for further research.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Wolthuis AM, Bislenghi G, Fieuws S, de Buck van Overstraeten A, Boeckxstaens G, D’Hoore A (2016) Incidence of prolonged postoperative ileus after colorectal surgery: a systematic review and meta-analysis. Color Dis 1:O1–O9CrossRef Wolthuis AM, Bislenghi G, Fieuws S, de Buck van Overstraeten A, Boeckxstaens G, D’Hoore A (2016) Incidence of prolonged postoperative ileus after colorectal surgery: a systematic review and meta-analysis. Color Dis 1:O1–O9CrossRef
2.
Zurück zum Zitat Vather R, Trivedi S, Bissett I (2013) Defining postoperative ileus: results of a systematic review and global survey. J Gastrointest Surg 5:962–972CrossRef Vather R, Trivedi S, Bissett I (2013) Defining postoperative ileus: results of a systematic review and global survey. J Gastrointest Surg 5:962–972CrossRef
3.
Zurück zum Zitat Holte K, Kehlet H (2000) Postoperative ileus: a preventable event. Br J Surg 11:1480–1493CrossRef Holte K, Kehlet H (2000) Postoperative ileus: a preventable event. Br J Surg 11:1480–1493CrossRef
4.
Zurück zum Zitat Asgeirsson T, El-Badawi KI, Mahmood A, Barletta J, Luchtefeld M, Senagore AJ (2010) Postoperative ileus: it costs more than you expect. J Am Coll Surg 2:228–233CrossRef Asgeirsson T, El-Badawi KI, Mahmood A, Barletta J, Luchtefeld M, Senagore AJ (2010) Postoperative ileus: it costs more than you expect. J Am Coll Surg 2:228–233CrossRef
5.
Zurück zum Zitat Vather R, O’Grady G, Bissett IP, Dinning PG (2014) Postoperative ileus: mechanisms and future directions for research. Clin Exp Pharmacol Physiol 5:358–370CrossRef Vather R, O’Grady G, Bissett IP, Dinning PG (2014) Postoperative ileus: mechanisms and future directions for research. Clin Exp Pharmacol Physiol 5:358–370CrossRef
6.
Zurück zum Zitat Lee SY, Park KJ, Ryoo SB, HK O, Choe EK, Heo SC (2014) Early postoperative small bowel obstruction is an independent risk factor for subsequent adhesive small bowel obstruction in patients undergoing open colectomy. World J Surg 11:3007–3014CrossRef Lee SY, Park KJ, Ryoo SB, HK O, Choe EK, Heo SC (2014) Early postoperative small bowel obstruction is an independent risk factor for subsequent adhesive small bowel obstruction in patients undergoing open colectomy. World J Surg 11:3007–3014CrossRef
7.
Zurück zum Zitat Doorly MG, Senagore AJ (2012) Pathogenesis and clinical and economic consequences of postoperative ileus. Surg Clin North Am 2:259–272CrossRef Doorly MG, Senagore AJ (2012) Pathogenesis and clinical and economic consequences of postoperative ileus. Surg Clin North Am 2:259–272CrossRef
8.
Zurück zum Zitat Kranke P, Thompson JP, Dalby PL, et al. (2015) Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron. Br J Anaesth 3:423–429CrossRef Kranke P, Thompson JP, Dalby PL, et al. (2015) Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron. Br J Anaesth 3:423–429CrossRef
9.
Zurück zum Zitat Hsu CC, Sandford BA (2007) The Delphi technique: making sense of consensus. Practical Assessment, Research & Evaluation 10:1–8 Hsu CC, Sandford BA (2007) The Delphi technique: making sense of consensus. Practical Assessment, Research & Evaluation 10:1–8
10.
Zurück zum Zitat Fiore JF Jr, Bialocerkowski A, Browning L, Faragher IG, Denehy L (2012) Criteria to determine readiness for hospital discharge following colorectal surgery: an international consensus using the Delphi technique. Dis Colon rectum 4:416–423 Fiore JF Jr, Bialocerkowski A, Browning L, Faragher IG, Denehy L (2012) Criteria to determine readiness for hospital discharge following colorectal surgery: an international consensus using the Delphi technique. Dis Colon rectum 4:416–423
11.
Zurück zum Zitat Murphy MK, Black NA, Lamping DL, et al. (1998) Consensus development methods and their use in clinical guideline development. Health Technol Assessment 2:1–88 Murphy MK, Black NA, Lamping DL, et al. (1998) Consensus development methods and their use in clinical guideline development. Health Technol Assessment 2:1–88
13.
Zurück zum Zitat Hasson F, Keeney S, McKenna H (2000) Research guidelines for the Delphi survey technique. J Adv Nurs 32:1008–1015PubMed Hasson F, Keeney S, McKenna H (2000) Research guidelines for the Delphi survey technique. J Adv Nurs 32:1008–1015PubMed
14.
Zurück zum Zitat Roberts DM, Yates C, Megarbane B, et al. (2015) Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Crit Care Med 2:461–472CrossRef Roberts DM, Yates C, Megarbane B, et al. (2015) Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Crit Care Med 2:461–472CrossRef
15.
Zurück zum Zitat Swamy M, Venkatachalam S, McLachlan J (2014) A Delphi consensus study to identify current clinically most valuable orthopaedic anatomy components for teaching medical students. BMC Med Educ 14:230CrossRefPubMedPubMedCentral Swamy M, Venkatachalam S, McLachlan J (2014) A Delphi consensus study to identify current clinically most valuable orthopaedic anatomy components for teaching medical students. BMC Med Educ 14:230CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Dijkstra FA, Bosker RJ, Veeger NJ, van Det MJ, Pierie JP (2015) Procedural key steps in laparoscopic colorectal surgery, consensus through Delphi methodology. Surg Endosc 9:2620–2627CrossRef Dijkstra FA, Bosker RJ, Veeger NJ, van Det MJ, Pierie JP (2015) Procedural key steps in laparoscopic colorectal surgery, consensus through Delphi methodology. Surg Endosc 9:2620–2627CrossRef
17.
Zurück zum Zitat Jacobs M, Henselmans I, Macefield RC, et al. (2014) Delphi survey to identify topics to be addressed at the initial follow-up consultation after oesophageal cancer surgery. Br J Surg 13:1692–1701CrossRef Jacobs M, Henselmans I, Macefield RC, et al. (2014) Delphi survey to identify topics to be addressed at the initial follow-up consultation after oesophageal cancer surgery. Br J Surg 13:1692–1701CrossRef
18.
Zurück zum Zitat Bonrath EM, Grantcharov TP (2015) Contemporary management of paraesophaegeal hernias: establishing a European expert consensus. Surg Endosc 8:2180–2195CrossRef Bonrath EM, Grantcharov TP (2015) Contemporary management of paraesophaegeal hernias: establishing a European expert consensus. Surg Endosc 8:2180–2195CrossRef
19.
Zurück zum Zitat Sandrasegaran K, Maglinte DD (2015) Imaging of small bowel-related complications following major abdominal surgery. Eur J Radiol 3:374–386 Sandrasegaran K, Maglinte DD (2015) Imaging of small bowel-related complications following major abdominal surgery. Eur J Radiol 3:374–386
21.
Zurück zum Zitat Gan TJ, Diemunsch P, Habib AS, et al. (2014) Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 1:85–113CrossRef Gan TJ, Diemunsch P, Habib AS, et al. (2014) Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 1:85–113CrossRef
22.
Zurück zum Zitat Shussman N, Brown MR, Johnson MC, Da Silva G, Wexner SD, Weiss EG (2013) Does nasogastric tube decompression get used less often with laparoscopic and hand-assisted compared with open colectomy? Surg Endosc 12:4564–4568CrossRef Shussman N, Brown MR, Johnson MC, Da Silva G, Wexner SD, Weiss EG (2013) Does nasogastric tube decompression get used less often with laparoscopic and hand-assisted compared with open colectomy? Surg Endosc 12:4564–4568CrossRef
23.
Zurück zum Zitat Sirivanasandha P (1995) Postoperative nausea vomiting (PONV): influence of bowel manipulation during intraabdominal surgery. J Med Assoc Thail 10:547–553 Sirivanasandha P (1995) Postoperative nausea vomiting (PONV): influence of bowel manipulation during intraabdominal surgery. J Med Assoc Thail 10:547–553
24.
Zurück zum Zitat St Peter SD, Tsao K, Sharp SW, Holcomb GW, Ostlie DJ (2008) Predictors of emesis and time to goal intake after pyloromyotomy: analysis from aprospective trial. J Pediatr Surg 11:2038–2041CrossRef St Peter SD, Tsao K, Sharp SW, Holcomb GW, Ostlie DJ (2008) Predictors of emesis and time to goal intake after pyloromyotomy: analysis from aprospective trial. J Pediatr Surg 11:2038–2041CrossRef
25.
Zurück zum Zitat Wehner S, Vilz TO, Stoffels B, Kalff JC (2012) Immune mediators of postoperative ileus. Langenbeck's Arch Surg 4:591–601CrossRef Wehner S, Vilz TO, Stoffels B, Kalff JC (2012) Immune mediators of postoperative ileus. Langenbeck's Arch Surg 4:591–601CrossRef
26.
Zurück zum Zitat Gustafsson UO, Scott MJ, Schwenk W, et al. (2013) Guidelines for perioperative care in elective colonic surgery: enhanced recovery after surgery (ERAS((R))) society recommendations. World J Surg, 2:259–284. Gustafsson UO, Scott MJ, Schwenk W, et al. (2013) Guidelines for perioperative care in elective colonic surgery: enhanced recovery after surgery (ERAS((R))) society recommendations. World J Surg, 2:259–284.
27.
Zurück zum Zitat Pöpping DM, Elia N, Van Aken HK, et al. (2014) Impact of epidural analgesia on mortality and morbidity after surgery: systematic review and meta-analysis of randomized controlled trials. Ann Surg 6:1056–1067CrossRef Pöpping DM, Elia N, Van Aken HK, et al. (2014) Impact of epidural analgesia on mortality and morbidity after surgery: systematic review and meta-analysis of randomized controlled trials. Ann Surg 6:1056–1067CrossRef
28.
Zurück zum Zitat Lobo DN (2004) Fluid, electrolytes and nutrition: physiological and clinical aspects. The Proceedings of the Nutrition Society 3:453–466CrossRef Lobo DN (2004) Fluid, electrolytes and nutrition: physiological and clinical aspects. The Proceedings of the Nutrition Society 3:453–466CrossRef
29.
Zurück zum Zitat Traut U, Brügger L, Kunz R, et al. (2008) Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus followingabdominal surgery in adults. Cochrane Database Syst Rev 1:CD004930 Traut U, Brügger L, Kunz R, et al. (2008) Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus followingabdominal surgery in adults. Cochrane Database Syst Rev 1:CD004930
30.
Zurück zum Zitat Shariat Moharari R, Motalebi M, Najafi A, et al. (2013) Magnesium can decrease postoperative physiological ileus and postoperative pain in major non laparoscopic gastrointestinal surgeries: a randomized controlled trial. Anesth Pain Med 1:e12750 Shariat Moharari R, Motalebi M, Najafi A, et al. (2013) Magnesium can decrease postoperative physiological ileus and postoperative pain in major non laparoscopic gastrointestinal surgeries: a randomized controlled trial. Anesth Pain Med 1:e12750
31.
Zurück zum Zitat van den Heijkant TC, Costes LM, van der Lee DG, et al. (2015) Randomized clinical trial of the effect of gum chewing on postoperative ileus and inflammation in colorectal surgery. Br J Surg 3:202–211CrossRef van den Heijkant TC, Costes LM, van der Lee DG, et al. (2015) Randomized clinical trial of the effect of gum chewing on postoperative ileus and inflammation in colorectal surgery. Br J Surg 3:202–211CrossRef
32.
Zurück zum Zitat van Bree SH, Bemelman WA, Hollmann MW, et al. (2014) Identification of clinical outcome measures for recovery of gastrointestinal motility in postoperativeileus. Ann Surg 4:708–714CrossRef van Bree SH, Bemelman WA, Hollmann MW, et al. (2014) Identification of clinical outcome measures for recovery of gastrointestinal motility in postoperativeileus. Ann Surg 4:708–714CrossRef
33.
Zurück zum Zitat Vather R, Bissett I (2013) Management of prolonged post-operative ileus: evidence-based recommendations. ANZ J Surg 5:319–324CrossRef Vather R, Bissett I (2013) Management of prolonged post-operative ileus: evidence-based recommendations. ANZ J Surg 5:319–324CrossRef
34.
Zurück zum Zitat Branco BC, Barmparas G, Schnuriger B, Inaba K, Chan LS, Demetriades D (2010) Systematic review and meta-analysis of the diagnostic and therapeutic role of water-soluble contrast agent in adhesive small bowel obstruction. Br J Surg 4:470–478CrossRef Branco BC, Barmparas G, Schnuriger B, Inaba K, Chan LS, Demetriades D (2010) Systematic review and meta-analysis of the diagnostic and therapeutic role of water-soluble contrast agent in adhesive small bowel obstruction. Br J Surg 4:470–478CrossRef
35.
Zurück zum Zitat Zeinali F, Stulberg JJ, Delaney CP (2009) Pharmacological management of postoperative ileus. Can J Surg 2:153–157 Zeinali F, Stulberg JJ, Delaney CP (2009) Pharmacological management of postoperative ileus. Can J Surg 2:153–157
36.
Zurück zum Zitat Elledge RO, McAleer S (2015) Planning the content of a brief educational course in maxillofacial emergencies for staff in accident and emergency departments: a modified Delphi study. Br J Oral Maxillofac Surg 2:109–113CrossRef Elledge RO, McAleer S (2015) Planning the content of a brief educational course in maxillofacial emergencies for staff in accident and emergency departments: a modified Delphi study. Br J Oral Maxillofac Surg 2:109–113CrossRef
37.
Zurück zum Zitat Nagpal K, Arora S, Abboudi M, et al. (2010) Postoperative handover: problems, pitfalls, and prevention of error. Ann Surg 1:171–176CrossRef Nagpal K, Arora S, Abboudi M, et al. (2010) Postoperative handover: problems, pitfalls, and prevention of error. Ann Surg 1:171–176CrossRef
38.
Zurück zum Zitat Fesharakizadeh M, Taheri D, Dolatkhah S, Wexner SD (2013) Postoperative ileus in colorectal surgery: is there any difference between laparoscopic and open surgery? Gastroenterol Rep (Oxf) 2:138–143CrossRef Fesharakizadeh M, Taheri D, Dolatkhah S, Wexner SD (2013) Postoperative ileus in colorectal surgery: is there any difference between laparoscopic and open surgery? Gastroenterol Rep (Oxf) 2:138–143CrossRef
Metadaten
Titel
Postoperative ileus: in search of an international consensus on definition, diagnosis, and treatment
verfasst von
Daniel Gero
Olivier Gié
Martin Hübner
Nicolas Demartines
Dieter Hahnloser
Publikationsdatum
03.08.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Langenbeck's Archives of Surgery / Ausgabe 1/2017
Print ISSN: 1435-2443
Elektronische ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-016-1485-1

Weitere Artikel der Ausgabe 1/2017

Langenbeck's Archives of Surgery 1/2017 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.