The sodium/glucose cotransport family SLC5

Pflugers Arch - Eur J Physiol (2003) DOI 10.1007/s00424-003-1063-6

Figure 1 and Table 1 have been revised to reflect the recently approved HUGO gene names for newer members of the SLC5 family, namely those for AIT (SLC5A8) and SGLTs 4-6 (SLC5A9-11). In addition, a reference has been added documenting the function of SGLT3 (SLC5A4) as a glucose sensor.

Fig. 1

Unrooted phylogenetic tree of the 11 human members of the SLC5 family of cotransporters and two other vertebrate members of known function. The alignment program CLUSTAL W (http://www.ebi.ac.uk/clustalw/) and the phylogenetic display program TreeViewPPC (http://taxonomy.zoology.gla.ac.uk/rod/treeview.html) were used to generate the tree. Members for which transport functions have been demonstrated experimentally are shown in red. Members shown in black have yet to have their function determined. In a pairwise basic local alignment search tool (BLAST) analysis the amino acid identities relative to SGLT1 (SLC5A1) were 59% SGLT2, 70% SGLT3, 56% SGLT4, 57% SGLT5, 50% SGLT6, 55% SMIT, 24% SMVT, 24% CHT, 21% AIT, and 21% NIS (SGLT Na⁺/glucose transporter, SMIT Na⁺/myo-inositol transporter, SMVT Na⁺/multivitamin transporter, CHT choline transporter, AIT apical iodide transporter, NIS Na⁺/iodide transporter)

Table 1 The SLC5 sodium glucose cotransporter family (OMIM Online Mendelian Inheritance in Man database, TMHtransmembrane helix, aa amino acids)