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The influence of extracellular and intracellular calcium on the secretion of renin

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Abstract

Changes in plasma, extracellular, and intracellular calcium can affect renin secretion from the renal juxtaglomerular (JG) cells. Elevated intracellular calcium directly inhibits renin release from JG cells by decreasing the dominant second messenger intracellular cyclic adenosine monophosphate (cAMP) via actions on calcium-inhibitable adenylyl cyclases and calcium-activated phosphodiesterases. Increased extracellular calcium also directly inhibits renin release by stimulating the calcium-sensing receptor (CaSR) on JG cells, resulting in parallel changes in the intracellular environment and decreasing intracellular cAMP. In vivo, acutely elevated plasma calcium inhibits plasma renin activity (PRA) via parathyroid hormone-mediated elevations in renal cortical interstitial calcium that stimulate the JG cell CaSR. However, chronically elevated plasma calcium or CaSR activation may actually stimulate PRA. This elevation in PRA may be a compensatory mechanism resulting from calcium-mediated polyuria. Thus, changing the extracellular calcium in vitro or in vivo results in inversely related acute changes in cAMP, and therefore renin release, but chronic changes in calcium may result in more complex interactions dependent upon the duration of changes and the integration of the body’s response to these changes.

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Sources of funding

This research was supported by funding from the National Institutes of Health (NIH) from grants F30DK084654-03 and PPG 5PO1HL090550-03. Mr. Atchison is a member of the Wayne State University School of Medicine MD/PhD program.

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There are no conflicts or disclosures to report.

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Authors and Affiliations

  1. Hypertension and Vascular Research Division, Department Internal Medicine, Henry Ford Hospital, 7121 E&R Bldg., 2799 W. Grand Blvd., Detroit, MI, 48202, USA

    Douglas K. Atchison & William H. Beierwaltes

  2. Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA

    Douglas K. Atchison & William H. Beierwaltes

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  1. Douglas K. Atchison
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  2. William H. Beierwaltes
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Correspondence to William H. Beierwaltes.

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This article is published as part of the special issue on Renin-Angiotensin System.

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Atchison, D.K., Beierwaltes, W.H. The influence of extracellular and intracellular calcium on the secretion of renin. Pflugers Arch - Eur J Physiol 465, 59–69 (2013). https://doi.org/10.1007/s00424-012-1107-x

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  • DOI: https://doi.org/10.1007/s00424-012-1107-x

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