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Erschienen in: Virchows Archiv 2/2004

01.02.2004 | Original Article

Oligoclonal T-cell populations in an inflammatory pseudotumor of the pancreas possibly related to autoimmune pancreatitis: an immunohistochemical and molecular analysis

verfasst von: Irene Esposito, Frank Bergmann, Roland Penzel, Fabio F. di Mola, Shailesh Shrikhande, Markus W. Büchler, Helmut Friess, Herwart F. Otto

Erschienen in: Virchows Archiv | Ausgabe 2/2004

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Abstract

Inflammatory pseudotumors (IPT), also known as inflammatory myofibroblastic tumors (IMT), are benign inflammatory processes that may have an infectious etiology and are very rare in the pancreatico-biliary region. Recent studies suggest a biological distinction between IPT and IMT, the latter being a true neoplastic process. We describe a case of pancreatic IPT, originally diagnosed as malignancy, which presumably recurred 4 months after the operation. Histologically, the tumor consisted of a smooth muscle actin and CD68-positive spindle cell population and a more abundant mononuclear inflammatory cell population, primarily composed of macrophages and T-lymphocytes. Inflammatory cells were the source of connective tissue growth factor and transforming growth factor-β1 and tended to accumulate around nerves and blood vessels, as well as around residual pancreatic parenchymal elements, where an intense angiogenetic response was detected. Comparative genomic hybridization analysis of the tumor showed no chromosomal imbalances. Polymerase chain reaction-based analysis of T-cell receptor γ gene rearrangement revealed an oligoclonal pattern. These findings suggest that the pathogenesis of aggressive cases of IPT could be related to the development of an intense and self-maintaining immune response, with the emergence of clonal populations of T-lymphocytes. The relation of the pancreatic IPT to autoimmune pancreatitis is emphasized.
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Metadaten
Titel
Oligoclonal T-cell populations in an inflammatory pseudotumor of the pancreas possibly related to autoimmune pancreatitis: an immunohistochemical and molecular analysis
verfasst von
Irene Esposito
Frank Bergmann
Roland Penzel
Fabio F. di Mola
Shailesh Shrikhande
Markus W. Büchler
Helmut Friess
Herwart F. Otto
Publikationsdatum
01.02.2004
Verlag
Springer-Verlag
Erschienen in
Virchows Archiv / Ausgabe 2/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-003-0949-1

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