Skip to main content
Erschienen in: Virchows Archiv 5/2004

01.05.2004 | Letter to the Editor

Osteoclastogenesis in human breast carcinoma

verfasst von: Makoto Sano, Kentaro Kikuchi, Chen Zhao, Michiyo Kobayashi, Yoko Nakanishi, Norimichi Nemoto

Erschienen in: Virchows Archiv | Ausgabe 5/2004

Einloggen, um Zugang zu erhalten

Excerpt

Dear Sir, We herein report the involvement of vascular endothelial growth factor (VEGF) expression and osteoclast-like giant cell (OGC) formation in human breast carcinoma. We believe that OGCs are osteoclasts derived from peripheral blood macrophages, while overexpression of VEGF in the carcinoma cells may play a pivotal role in the osteoclastogenesis. …
Literatur
1.
Zurück zum Zitat Akagawa KS, Takasuka N, Nozaki Y, Komuro I, Azuma M, Ueda M, Naito M, Takahashi K (1996) Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes. Blood 88:4029–4039PubMed Akagawa KS, Takasuka N, Nozaki Y, Komuro I, Azuma M, Ueda M, Naito M, Takahashi K (1996) Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes. Blood 88:4029–4039PubMed
2.
Zurück zum Zitat Heinemann DE, Siggelkow H, Ponce LM, Viereck V, Wiese KG, Peters JH (2000) Alkaline phosphatase expression during monocyte differentiation. Overlapping markers as a link between monocytic cells, dendritic cells, osteoclasts and osteoblasts. Immunobiology 202:68–81PubMed Heinemann DE, Siggelkow H, Ponce LM, Viereck V, Wiese KG, Peters JH (2000) Alkaline phosphatase expression during monocyte differentiation. Overlapping markers as a link between monocytic cells, dendritic cells, osteoclasts and osteoblasts. Immunobiology 202:68–81PubMed
3.
Zurück zum Zitat Nakagawa M, Kaneda T, Arakawa T, Morita S, Sato T, Yomada T, Hanada K, Kumegawa M, Hakeda Y (2000) Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett 473:161–164CrossRefPubMed Nakagawa M, Kaneda T, Arakawa T, Morita S, Sato T, Yomada T, Hanada K, Kumegawa M, Hakeda Y (2000) Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett 473:161–164CrossRefPubMed
4.
Zurück zum Zitat Niida S, Kaku M, Amano H, Yoshida H, Kataoka H, Nishikawa S, Tanne K, Maeda N, Kodama H (1999) Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med 190:293–298CrossRefPubMed Niida S, Kaku M, Amano H, Yoshida H, Kataoka H, Nishikawa S, Tanne K, Maeda N, Kodama H (1999) Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med 190:293–298CrossRefPubMed
Metadaten
Titel
Osteoclastogenesis in human breast carcinoma
verfasst von
Makoto Sano
Kentaro Kikuchi
Chen Zhao
Michiyo Kobayashi
Yoko Nakanishi
Norimichi Nemoto
Publikationsdatum
01.05.2004
Verlag
Springer-Verlag
Erschienen in
Virchows Archiv / Ausgabe 5/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-004-0989-1

Weitere Artikel der Ausgabe 5/2004

Virchows Archiv 5/2004 Zur Ausgabe

Announcements

May 2004

Neu im Fachgebiet Pathologie