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Virchows Archiv
Erschienen in: Virchows Archiv 5/2005

01.05.2005 | Review Article

NF-kB in development and progression of human cancer

verfasst von: Xavier Dolcet, David Llobet, Judit Pallares, Xavier Matias-Guiu

Erschienen in: Virchows Archiv | Ausgabe 5/2005

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Abstract

The nuclear factor kB (NF-kB) comprises a family of transcription factors involved in the regulation of a wide variety of biological responses. NF-kB plays a well-known function in the regulation of immune responses and inflammation, but growing evidences support a major role in oncogenesis. NF-kB regulates the expression of genes involved in many processes that play a key role in the development and progression of cancer such as proliferation, migration and apoptosis. Aberrant or constitutive NF-kB activation has been detected in many human malignancies. In recent years, numerous studies have focused on elucidating the functional consequences of NF-kB activation as well as its signaling mechanisms. NF-kB has turned out to be an interesting therapeutic target for treatment of cancer.
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Metadaten
Titel
NF-kB in development and progression of human cancer
verfasst von
Xavier Dolcet
David Llobet
Judit Pallares
Xavier Matias-Guiu
Publikationsdatum
01.05.2005
Erschienen in
Virchows Archiv / Ausgabe 5/2005
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-005-1264-9

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