Abstract
The origin of cystadenolymphoma (Warthin’s tumour) of the parotid gland is unknown. According to the most favoured hypothesis, Warthin’s tumour results from the proliferation of salivary gland ductal cells that were entrapped in parotid lymph nodes during embryonal life. If this is correct, and the almost total lack of recurrence and malignant transformation of this lesion lends credence to this view, Warthin’s tumour is correctly classified in the group of tumour-like lesions and should not be considered to be a monomorphic adenoma.
Similar content being viewed by others
References
Aguirre JM, Echebarria MA, Martinez-Conde R, Rodriguez C, Burgos JJ, Rivera JM (1998) Warthin tumor. A new hypothesis concerning its development. Oral Surg Oral Med Oral Pathol Oral Radiol Endo 85:60–63
Albrecht H, Arzt L (1910) Beiträge zur Frage der Gewebsverirrung. I. Papilläre Cystadenome in Lymphdrüsen. Frankfurt Z Pathol 4:47–69
Allegra SR (1971) Warthin’s tumor: a hypersensitivity disease? Ultrastructural, light, and immunofluorescent study. Hum Pathol 2:403–420
Allen JA, Coombs MM (1980) Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA. Nature 287:244–245
Batsakis JG, Regezi JA (1987) The pathology of head and neck tumors: salivary glands, part 1. Head Neck Surg 1:59–68
Chapnik JS (1983) The controversy of Warthin’s tumor. Laryngoscope 93:695–716
Foschini MP, Malvi D, Betts CM (2005) Oncocytic carcinoma arising in Warthin tumour. Virchows Arch 446:88–90
Gallo O, Bocciolini C (1997) Warthin’s tumour associated with autoimmune diseases and tobacco use. Acta Otolaryngol 117:623–627
Hildebrand O (1895) Über angeborene epitheliale Cysten und Fisteln des Halses. Arch Klin Chir 49:167–206
Honda K, Kashima K, Daa T, Yokoyama S, Nakayama I (2000) Clonal analysis of the epithelial component of Warthin’s tumor. Hum Pathol 31:1377–1380
Laane CJ, Murr AH, Mhatre AN, Jones KD, Lalwani AK (2002) Role of Epstein-Barr virus and cytomegalovirus in the etiology of benign parotid tumors. Head Neck 24:443–450
Leverstein H, van der Wal JE, Tiwari RM, van der Waal I, Snow GB (1997) Results of the surgical management and histopathological evaluataion of 88 parotid gland Warthin’s tumours. Clin Otolaryngol 22:500–503
Lewis PD, Baxter P, Paul Griffiths A, Parry JM, Skibinski DO (2000) Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin’s tumour. J Pathol 191:274–281
Martins C, Fonseca I, Roque L, Soares J (1997) Cytogentic characterisation of Warthin’s tumour. Oral Oncol 33:344–347
Ogawa Y, Hong SS, Toyosawa S, Chang CC, Yagi T (1990) Expression of major histocompatibility complex class II antigens and interleukin-1 by epithelial cells of Warthin’s tumor. Cancer 66:2111–2117
Patterson JW, Wright ED, Camden S (1999) Extraparotid Warthin’s tumor. J Am Acad Dermatol 40:468–470
Pinkston JA, Cole P (1999) Incidence rates of salivary gland tumors: results from a population-based study. Otolaryngol Head Neck Surg 120:834–840
Rauch S (ed) (1959) Papilläre Zystadenolymphome. (Die Speicheldrüsen des Menschen) Thieme, Stuttgart, pp 368–373
Santucci M, Gallo O, Calzolari A, Bondi R (1993) Detection of Epstein-Barr viral genome in tumor cells of Warthin’s tumor of parotid gland. Am J Clin Pathol 100:662–665
Schwerer MJ, Kraft K, Baczako K, Maier H (2001) Cytokeratin expression and epithelial differentiation in Warthin’s tumour and its metaplastic (infarcted) variant. Histopathology 39:347–352
Seifert G (1992) Tumour-like lesions of the salivary glands. The new WHO classification. Pathol Res Pract 188:836–846
Seifert G (1996) Warthin tumoren (Adenolymphome). In: Doerr W, Seifert G, Uehlinger E (eds) Oralpathologie I, Pathologie der Speicheldrüsen. Springer, Berlin Heidelberg New York, pp 440–463
Seifert G, Bull HG, Donath K (1980) Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch A Pathol Anat 388:13–38
Stoll W, Huttenbrink KB (1982) Die laterale halszyste: eine lymphknotenerkrankung. Laryngol Rhinol Otol 61:272–275
Takezawa K, Jackson C, Gnepp DR, King TC (1998) Molecular characterization of Warthin tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endo 85:569–575
Teymoortash A, Lippert BM, Werner JA (2001) Steroid hormone receptors in parotid gland cystadenolymphoma (Warthin’s tumour). Clin Otolaryngol 26:411–416
Thompson AS, Bryant HC (1950) Histogenesis of papillary cystadenoma lymphomatosum (Warthin’s tumor) of the parotid salivary gland. Am J Pathol 26:807–829
Warthin AS (1929) Papillary cystadenoma lymphomatosum. A rare teratoid of the parotid region. J Cancer Res 13:116–125
Wild G, Mischke D, Lobeck H, Kastenbauer E (1987) The lateral cyst of the neck: congenital or acquired? Acta Otolaryngol 103:546–550
Yu GY, Liu XB, Li ZL, Peng X (1998) Smoking and the development of Warthin’s tumour of the parotid gland. Br J Oral Maxillofac Surg 36:183–185
Acknowledgements
The authors would like to thank Professor Günter Klöppel and Kay Dege for critically reading the manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Teymoortash, A., Werner, J.A. Tissue that has lost its track: Warthin’s tumour. Virchows Arch 446, 585–588 (2005). https://doi.org/10.1007/s00428-005-1276-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00428-005-1276-5