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Virchows Archiv

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01.08.2006 | Case Report

Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report

verfasst von: Catherine Butori, Véronique Hofman, Rita Attias, Jerôme Mouroux, Florence Pedeutour, Paul Hofman

Erschienen in: Virchows Archiv | Ausgabe 2/2006

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Abstract

Synovial sarcoma (SS) is an uncommon soft tissue tumor occurring mainly in the periarticular region of the extremities of young adults. In this report, we describe a very rare occurrence of primary SS of the esophagus in a 72-year-old woman. Histologically, the tumor demonstrated biphasic morphologic findings associated with poorly differentiated areas. Tumor cells expressed vimentin, epithelial (EMA, CK7, AE1/3), bcl-2 and neuroectodermal (CD56, CD57, CD99) antigens. Differential diagnose included esophageal sarcomatoid carcinoma. Cytogenetic analysis confirmed the diagnosis of SS by identifying t(X;18) translocation. The literature of this very uncommon entity of the esophagus is reviewed.

Amr SS, Shihabi NK, Al Hajj H (1984) Synovial sarcoma of the esophagus. Am J Otolaryngol 5:266–269PubMedCrossRef

Anton-Pacheco J, Cano I, Cuadros J, Vilarino A, Berchi F (1996) Synovial sarcoma of the esophagus. J Pediatr Surg 31:1703–1705PubMedCrossRef

Billings SD, Meisner LF, Cummings OW, Tjada E (2000) Synovial sarcoma of the upper digestive tract : a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization. Mod Pathol 13:68–76PubMedCrossRef

Bloch MJ, Iozzo RV, Edmunds LH Jr, Brooks JJ (1987) Polypoid synovial sarcoma of the esophagus. Gastroenterology 92:229–233PubMed

Bonavina L, Fociani P, Asnaghi D, Ferrero S (1998) Synovial sarcoma of the esophagus simulating achalasia. Dis Esophagus 11:268–271PubMed

Fisher C (1998) Synovial sarcoma. Ann Diagn Pathol 2:401–421PubMedCrossRef

Habu S, Okamoto E, Toyosaka A, Nakai Y, Takeuchi M (1998) Synovial sarcoma of the esophagus: report of a case. Surg Today 28:401–404PubMedCrossRef

Hamilton SR, Aaltonen LA (eds) (2000) World Health Organization classification of tumours of the digestive system. IARC, Lyon

Hasegawa T, Yamamoto S, Nojima T, Hirose T, Nikaido T, Yamashiro K, Matsuno Y (2002) Validity and reproducibility of histologic diagnosis and grading for adult soft-tissue sarcomas. Hum Pathol 33:111–115PubMedCrossRef

10.

Kawauchi S, Kukuda T, Oda Y, Saito T, Olga A, Takeshita M, Yokohama K, Chuman H, Iwamoto Y, sasaki K, Tsuneyoshi M (2000) Prognostic significance of apoptosis in synovial sarcoma: correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins. Mod Pathol 13:755–765PubMedCrossRef

11.

Kwon MS, Hong SJ, Cho HA, Ahn GH, Lee SS, Lee KY, Rhyu MG (2003) Extensive and divergent chromosomal losses in squamous and spindle-cell components of esophageal sarcomatoid carcinoma. Virchows Arch 443:635–642PubMedCrossRef

12.

Limon J, Dal Cin P, Sandberg AA (1986) Application of long-term collagenase disaggregation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet 23:305–313PubMedCrossRef

13.

Matsumoto T, Fujii H, Arakawa A, Yamasaki S, Sonoue H, Hattori K, Kajiyama Y, Hirose S, Tsurumaru M (2004) Loss of heterozygosity analysis shows monoclonal evolution with frequent genetic progression and divergence in esophageal carcinosarcoma. Hum Pathol 35:322–327PubMedCrossRef

14.

Mitelman F (ed) (1995) ISCN: an international system for human cytogenetic nomenclature. Karger, Basel

15.

Nilsson G, Skytting B, Xie Y, Brodin B, Perfekt R, Mandahl N, Lundeberg J, Uhlen M, Larsson O (1999) The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Cancer Res 59:3180–3184PubMed

16.

Ohtaka M, Kumasaka T, Nobukawa B, Hirai S, Suda K, Ohno Y, Iwasaki R, Ikegami Y, Fukasawa M (2002) Carcinosarcoma of the esophagus characterized by myoepithelial and ductal differentiations. Pathol Int 52:657–663PubMedCrossRef

17.

Palmer Bv, Levene A, Shaw HJ (1983) Synovial sarcoma of the pharynx and esophagus. J Laryngol Otol 97:1173–1176PubMedCrossRef

18.

Perch SJ, Soffen EM, Whittington R, Brooks JJ (1991) Esophageal sarcomas. Surg Oncol 48:194–198CrossRef

19.

Rosen G, Forsher C, Lowenbraun S, Eilber F, Eckardt J, Holmes C, Fu YS (1993) Synovial sarcoma. A study of intensive chemotherapy in 14 patients with localized disease. Cancer 73:2506–2511CrossRef

20.

Trassard M, Le Doussal V, Hacene K, Terrier P, Ranchere D, Guillou L, Fiche M, Collin F, Vilain MO, Bertrand G, Jacquemier J, Sastre-Garau X, Bui NB, Bonichon F, Coindre JM (2001) Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients. J Clin Oncol 19:525–534PubMed

21.

Weiss SW, Goldblum JR (2001) Malignant soft tissue tumors of uncertain type. In: Weiss SW, Goldblum JR (eds) Enzinger and Weiss’s soft tissue tumors, 4th edn. Mosby, St Louis, MO, pp 1483–1571

Titel: Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report
verfasst von: Catherine Butori
Véronique Hofman
Rita Attias
Jerôme Mouroux
Florence Pedeutour
Paul Hofman
Publikationsdatum: 01.08.2006
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 2/2006
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0234-1

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

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Diagnosis of primary esophageal synovial sarcoma by demonstration of t(X;18) translocation: a case report

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