nach oben

Erschienen in:

01.05.2008 | Case Report

Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma

verfasst von: Aurelia Noske, Michael Schwabe, Stefan Pahl, Eva Fallenberg, Christiane Richter-Ehrenstein, Manfred Dietel, Glen Kristiansen

Erschienen in: Virchows Archiv | Ausgabe 5/2008

Einloggen, um Zugang zu erhalten

Abstract

Metaplastic carcinoma of the breast is a heterogeneous neoplasia, generally composed of both epithelial and mesenchymal components. We report an unusual case of mammary metaplastic carcinoma in a 51-year-old female patient. Needle core biopsy from the tumour mass showed malignant epithelial and sarcomatous features. The resection specimen revealed a multi-directional tumour differentiation consisting predominantly of: firstly, a poorly differentiated basaloid epithelial cell type, consistent with an adenoid cystic carcinoma; secondly, areas of a spindle cell carcinoma; and, thirdly, areas with a melanocytic differentiation. This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma.

Azoulay S, Laé M, Fréneaux P, Merle S, Ghuzlan A, Chnecker C, Rosty C, Klijanienko J, Sigal-Zafrani B, Salmon R, Fourquet A, Sastre-Garau X, Vincent-Salomon A (2005) KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favourable outcome. Mod Path 18:1623–1631

Barnes PJ, Boutilier R, Chiasson D, Rayson D (2005) Metaplastic breast carcinoma: clinical–pathologic characteristics and HER2/neu expression. Breast Cancer Res Treat 91:173–178PubMedCrossRef

Eusebi V, Cattan MG, Ceccarelli C, Lamovec J (1989) Sarcomatoid carcinoma of the breast: an immunocytochemical study of 14 cases. Prog Surg Pathol 10:83–99

Kaufman MW, Marti JR, Gallager HS, Hoehn JL (1984) Carcinoma of the breast with pseudosarcomatous metaplasia. Cancer 53:1908–1917PubMedCrossRef

Nobukawa B, Fujii H, Hirai S, Kumasaka T, Shimizu H, Matsumoto T, Suda K, Futagawa S (1999) Breast carcinoma diverging to aberrant melanocytic differentiation: a case report with histopathologic and loss of heretozygosity analyses. Am J Surg Pathol 23:1280–1287PubMedCrossRef

Padmore RF, Lara JF, Ackerman DJ, Gates T, Sigurdson ER, Ehya H, Cooper HS, Patchefsky AS (1996) Primary combined malignant melanoma and ductal carcinoma of the breast: a case report of two cases. Cancer 78:2515–2125PubMedCrossRef

Pia-Foschini M, Reis-Filho JS, Eusebi V, Lakhani SR (2003) Salivary gland-like tumours of the breast: surgical and molecular pathology. J Clin Pathol 56:497–506PubMedCrossRef

Ruffolo EF, Koerner FC, Maluf HM (1997) Metaplastic carcinoma of the breast with melanocytic differentiation. Mod Path 10:592–596

Shin SJ, Kanomata N, Rosen PP (2000) Mammary carcinoma with prominent cytoplasmic lipofuscin granules mimicking melanocytic differentiation. Histopathology 37:456–459PubMedCrossRef

10.

Tavassoli FA (1999) Pathology of the breast, 2nd ed. p 550

11.

Yen H, Florentine B, Koss Kelly L, Bu X, Crawford J, Martin SE (2000) Fine-needle aspiration of a metaplastic breast carcinoma with extensive melanocytic differentiation: a case report. Diagn Cytopathol 23:46–50PubMedCrossRef

Titel: Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma
verfasst von: Aurelia Noske
Michael Schwabe
Stefan Pahl
Eva Fallenberg
Christiane Richter-Ehrenstein
Manfred Dietel
Glen Kristiansen
Publikationsdatum: 01.05.2008
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 5/2008
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-008-0588-7

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma

Abstract

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2008

Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas

Impact of rapamycin on liver regeneration

Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with Polycomb repressive marks

The significance of lobular neoplasia on needle core biopsy of the breast

The role of COX-2 in rectal cancer treated with preoperative radiotherapy

Autopsy pathology should become a recognised subspecialty

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien