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01.12.2008 | Original Article

Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection

verfasst von: Kee-Taek Jang, Seung-Mo Hong, Kyu Taek Lee, Jong Gyun Lee, Seoung Ho Choi, Jin Seok Heo, Dong Wook Choi, Dongil Choi, Jae Hoon Lim

Erschienen in: Virchows Archiv | Ausgabe 6/2008

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Abstract

Intraductal papillary neoplasm of bile duct (IPNB) is one of the precursor lesions of cholangiocarcinoma. Although hepatolithiasis has been extensively studied in its association with IPNBs, there had been no comprehensive study of IPNBs with Clonorchis sinensis infection. Twelve IPNBs were selected from 20 surgically resected cholangiocarcinomas, positive for C. sinensis tests (60%) and compared with eight IPNBs, selected from 51 resected cholangiocarcinomas, negative for C. sinensis tests (16%), by histologic and immunohistochemical studies of mucin core proteins and cytokeratin panels. The predominant immuno-phenotype of IPNB cases with Clonorchiasis was pancreatobiliary type (MUC1+/MUC2-/CDX2-; 9/12 cases), while that of IPNB cases with negative for C. sinensis was intestinal type (MUC1-/MUC2+/CDX2+; 6/8; p = 0.04). The prevalence of IPNBs was higher when patients with cholangiocarcinoma had Clonorchiasis. IPNBs with Clonorchiasis tended to have a more pancreatobiliary phenotype, which suggests IPNBs with Clonorchiasis may have a different tumorigenesis pathway from IPNBs with other etiologies.

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Titel: Intraductal papillary neoplasm of the bile duct associated with Clonorchis sinensis infection
verfasst von: Kee-Taek Jang
Seung-Mo Hong
Kyu Taek Lee
Jong Gyun Lee
Seoung Ho Choi
Jin Seok Heo
Dong Wook Choi
Dongil Choi
Jae Hoon Lim
Publikationsdatum: 01.12.2008
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 6/2008
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-008-0682-x

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Abstract

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