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01.02.2009 | Original Article

Histopathological predictor for regional lymph node metastasis in gastric cancer

verfasst von: Hiroshi Morita, Yukio Ishikawa, Yuri Akishima-Fukasawa, Kinji Ito, Yoshikiyo Akasaka, Chiaki Nishimura, Yoshinori Igarashi, Kazumasa Miki, Toshiharu Ishii

Erschienen in: Virchows Archiv | Ausgabe 2/2009

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Abstract

Regional lymph node metastasis in gastric cancer is a definitive indicator of the patient’s prognosis. The goal of this study was to identify the predictors for lymph node metastasis among all the possible histopathological parameters, especially by conducting an objective discrimination of the lymphatic and blood vessels. A total of 210 resected primary gastric cancers with or without lymph node metastasis were evaluated based on the conventional histopathological parameters together with immunohistochemistry using antisera-recognizing lymphatic endothelial hyaluronan receptor-1 (LYVE-1), von Willebrand factor, and lymphangiogenesis promoter vascular endothelial growth factor-C (VEGF-C) antibodies. A multivariate regression analyses of the results indicated that only lymphatic invasion was a significant independent predictor of lymph node metastasis at any stage of cancer invasion. VEGF-C expression was partially related to lymph node metastasis in early gastric cancer. The identification of lymphatic invasion by LYVE-1 antibody is therefore useful to predict regional lymph node metastasis in gastric cancer.

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Titel: Histopathological predictor for regional lymph node metastasis in gastric cancer
verfasst von: Hiroshi Morita
Yukio Ishikawa
Yuri Akishima-Fukasawa
Kinji Ito
Yoshikiyo Akasaka
Chiaki Nishimura
Yoshinori Igarashi
Kazumasa Miki
Toshiharu Ishii
Publikationsdatum: 01.02.2009
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 2/2009
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-008-0717-3

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