Skip to main content
Erschienen in: Virchows Archiv 5/2014

01.11.2014 | Original Article

Identification of Giovanni Battista Morgagni remains following historical, anthropological, and molecular studies

verfasst von: Alberto Zanatta, Fabio Zampieri, Girolamo Zampieri, Alice Giuliodori, Gaetano Thiene, Luciana Caenazzo

Erschienen in: Virchows Archiv | Ausgabe 5/2014

Einloggen, um Zugang zu erhalten

Abstract

Morgagni died on December 5, 1771, 89 years old, and was buried in Saint Maxim Church in Padua, where his wife and five of his 15 children, four daughters, and one son were already buried. In 1868 and 1900, the tomb was opened to identify Morgagni. Among the remains of several adult individuals, two skulls considered of very old persons were identified and replaced in an earthenware jar inside the sepulcher. In 2011, we opened the tomb and found the remains described during the first two identifications, but additionally, we found the skulls fragments of three very young individuals which could have been Morgagni’s children. An anthropological analysis confirmed that one of the skulls inside the earthenware jar belonged to the oldest individuals (“senilis”) between those found in the tomb. A genetic analysis proved a kinship between this skull and the fragments of young individuals (one male and two females), supporting the hypothesis that they were Morgagni and his children. In conclusion, thanks to the interaction between historical studies, anthropological research, and molecular analysis that reinforce each other, we can assume that the skull is Giovanni Battista Morgagni’s and that the series of skull fragments are from his children who were buried together with their parents.
Literatur
1.
Zurück zum Zitat Zampieri F, Zanatta A, Thiene G (2014) An etymological “autopsy” of Morgagni’s title: de sedibus et causis morborum per anatomen indagatis (1761). Hum Pathol 45:12–16 Zampieri F, Zanatta A, Thiene G (2014) An etymological “autopsy” of Morgagni’s title: de sedibus et causis morborum per anatomen indagatis (1761). Hum Pathol 45:12–16
2.
Zurück zum Zitat Zampieri G (2012) Introduzione. In: Zampieri G (Ed), La Chiesa di San Massimo in Padova Cappella Universitaria. Archeologia Storia Arte intorno alla Chiesa di San Massimo. Risultati della ricognizione scientifica della tomba di Giovan Battista Morgagni e altri interventi, L’Erma di Bretschneider, Roma, pp. 19–37 Zampieri G (2012) Introduzione. In: Zampieri G (Ed), La Chiesa di San Massimo in Padova Cappella Universitaria. Archeologia Storia Arte intorno alla Chiesa di San Massimo. Risultati della ricognizione scientifica della tomba di Giovan Battista Morgagni e altri interventi, L’Erma di Bretschneider, Roma, pp. 19–37
3.
Zurück zum Zitat Morgagni GB (1712) Nova institutionum medicarum idea, Apud Josephum Coronam sub signo Coronae, Patavii Morgagni GB (1712) Nova institutionum medicarum idea, Apud Josephum Coronam sub signo Coronae, Patavii
4.
Zurück zum Zitat Thiene G (2012) Le celebrazioni morgagnane dell’anno accademico 2011-2012. In: Zampieri G (ed) La Chiesa di San Massimo in Padova Cappella Universitaria. Archeologia Storia Arte intorno alla Chiesa di San Massimo. Risultati della ricognizione scientifica della tomba di Giovan Battista Morgagni e altri interventi, L’Erma di Bretschneider, Roma, pp 219–258 Thiene G (2012) Le celebrazioni morgagnane dell’anno accademico 2011-2012. In: Zampieri G (ed) La Chiesa di San Massimo in Padova Cappella Universitaria. Archeologia Storia Arte intorno alla Chiesa di San Massimo. Risultati della ricognizione scientifica della tomba di Giovan Battista Morgagni e altri interventi, L’Erma di Bretschneider, Roma, pp 219–258
5.
Zurück zum Zitat Zampieri F, Zanatta A, Rippa Bonati M (2012) Ritratti di Morgagni nelle collezioni pubbliche padovane, Museo d’Arte medievale e moderna, biblioteca civica e Museo Bottacin. Cleup, Padova Zampieri F, Zanatta A, Rippa Bonati M (2012) Ritratti di Morgagni nelle collezioni pubbliche padovane, Museo d’Arte medievale e moderna, biblioteca civica e Museo Bottacin. Cleup, Padova
7.
Zurück zum Zitat Prinz M, Carracedo A, Mayr WR, Morling N, Parsons TJ, Sajantila A, Scheithauerg R, Schmitterh H, Schneideri PM (2007) DNA Commission of the International Society for Forensic Genetics (ISFG): recommendations regarding the role of forensic genetics for disaster victim identification (DVI). Forensic Sci. Int Genet 1:3–12. doi:10.1016/j.fsigen.2006.10.003 Prinz M, Carracedo A, Mayr WR, Morling N, Parsons TJ, Sajantila A, Scheithauerg R, Schmitterh H, Schneideri PM (2007) DNA Commission of the International Society for Forensic Genetics (ISFG): recommendations regarding the role of forensic genetics for disaster victim identification (DVI). Forensic Sci. Int Genet 1:3–12. doi:10.​1016/​j.​fsigen.​2006.​10.​003
8.
Zurück zum Zitat Andelinovic S, Sutlovic D, Erceg Ivkosic I, Skaro V, Ivkosic A, Paic F, Rezić B, Definis-Gojanović M, Primorac D (2005) Twelve-year experience in identification of skeletal remains from mass graves. Croat Med J 46:530–539PubMed Andelinovic S, Sutlovic D, Erceg Ivkosic I, Skaro V, Ivkosic A, Paic F, Rezić B, Definis-Gojanović M, Primorac D (2005) Twelve-year experience in identification of skeletal remains from mass graves. Croat Med J 46:530–539PubMed
9.
Zurück zum Zitat Alonso A, Andelinovic S, Martin P, Sutlovic D, Erceg I, Huffine E, de Simón LF, Albarrán C, Definis-Gojanović M, Fernández-Rodriguez A, García P, Drmić I, Rezić B, Kuret S, Sancho M, Primorac D (2001) DNA typing from skeletal remains: evaluation of multiplex and megaplex STR systems on DNA isolated from bone and teeth samples. Croat Med J 42:260–266PubMed Alonso A, Andelinovic S, Martin P, Sutlovic D, Erceg I, Huffine E, de Simón LF, Albarrán C, Definis-Gojanović M, Fernández-Rodriguez A, García P, Drmić I, Rezić B, Kuret S, Sancho M, Primorac D (2001) DNA typing from skeletal remains: evaluation of multiplex and megaplex STR systems on DNA isolated from bone and teeth samples. Croat Med J 42:260–266PubMed
10.
Zurück zum Zitat Reiss RA, Rutz B (1999) Quality control PCR: a method for detecting inhibitors of Taq DNA polymerase. Biotechniques 27(920–2):924–926 Reiss RA, Rutz B (1999) Quality control PCR: a method for detecting inhibitors of Taq DNA polymerase. Biotechniques 27(920–2):924–926
11.
Zurück zum Zitat Zhou J, Bruns MA, Tiedje JM (1996) DNA recovery from soils of diverse composition. Appl Environ Microbiol 62:316–322PubMedPubMedCentral Zhou J, Bruns MA, Tiedje JM (1996) DNA recovery from soils of diverse composition. Appl Environ Microbiol 62:316–322PubMedPubMedCentral
12.
Zurück zum Zitat Sutlovic D, Definis Gojanovic M, Andelinovic S, Gugic S, Primorac D (2005) Taq polymerase reverses inhibition of quantitative real time polymerase chain reaction by humic acid. Croat Med J 46:556–562PubMed Sutlovic D, Definis Gojanovic M, Andelinovic S, Gugic S, Primorac D (2005) Taq polymerase reverses inhibition of quantitative real time polymerase chain reaction by humic acid. Croat Med J 46:556–562PubMed
13.
Zurück zum Zitat Sutlovic D, Definis Gojanovic M, Andelinovic S (2007) Rapid extraction of human DNA containing humic acid. Croat Chem Acta 80:117–120 Sutlovic D, Definis Gojanovic M, Andelinovic S (2007) Rapid extraction of human DNA containing humic acid. Croat Chem Acta 80:117–120
15.
16.
Zurück zum Zitat Pearson K, Bell J (1917-1919) A study of long bones of the English skeleton. Part I. The femur. In: Draper’s Company, Research Memories University of London Chapters 1-4, Biometric series 10:1–224 Pearson K, Bell J (1917-1919) A study of long bones of the English skeleton. Part I. The femur. In: Draper’s Company, Research Memories University of London Chapters 1-4, Biometric series 10:1–224
17.
Zurück zum Zitat Black TK3rd (1978) A new method for assessing the sex of fragmentary skeletal remains: femoral shaft circumference. Am J Phys Anthropol 48:227–231 Black TK3rd (1978) A new method for assessing the sex of fragmentary skeletal remains: femoral shaft circumference. Am J Phys Anthropol 48:227–231
18.
Zurück zum Zitat Trotter M, Gleser GC (1958) A re-evaluation of estimation of stature based on measurements of stature taken during life and of long bones after death. Am J Phys Anthropol 16:79–123PubMedCrossRef Trotter M, Gleser GC (1958) A re-evaluation of estimation of stature based on measurements of stature taken during life and of long bones after death. Am J Phys Anthropol 16:79–123PubMedCrossRef
19.
Zurück zum Zitat Olivier G (1963) L’estimation de la stature par les os longs des membres, Bulletins et mémoires de la société d’Anthropologie de Paris. Série XI 4:433–449 Olivier G (1963) L’estimation de la stature par les os longs des membres, Bulletins et mémoires de la société d’Anthropologie de Paris. Série XI 4:433–449
20.
Zurück zum Zitat Capasso L, Kennedy KAR, Wilczak CA (1999) Atlas of occupational markers on human remains. Edigrafital s.p.a, Teramo Capasso L, Kennedy KAR, Wilczak CA (1999) Atlas of occupational markers on human remains. Edigrafital s.p.a, Teramo
21.
Zurück zum Zitat Meindl RS, Lovejoy CO (1985) Ectocranial suture closure: a revised method for the determination of skeletal age at death based on the lateral-anterior sutures. Am J Phys Anthropol 68:57–66PubMedCrossRef Meindl RS, Lovejoy CO (1985) Ectocranial suture closure: a revised method for the determination of skeletal age at death based on the lateral-anterior sutures. Am J Phys Anthropol 68:57–66PubMedCrossRef
22.
Zurück zum Zitat Martin R, Knuβmann VR (1988) Anthropologie. Handbuch der vergleichenden biologie des menschen. Band I. Wesen und Methoden der Anthropologie, Gustav Fischer Verlag, Stuttgart-New York Martin R, Knuβmann VR (1988) Anthropologie. Handbuch der vergleichenden biologie des menschen. Band I. Wesen und Methoden der Anthropologie, Gustav Fischer Verlag, Stuttgart-New York
Metadaten
Titel
Identification of Giovanni Battista Morgagni remains following historical, anthropological, and molecular studies
verfasst von
Alberto Zanatta
Fabio Zampieri
Girolamo Zampieri
Alice Giuliodori
Gaetano Thiene
Luciana Caenazzo
Publikationsdatum
01.11.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Virchows Archiv / Ausgabe 5/2014
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-014-1611-9

Weitere Artikel der Ausgabe 5/2014

Virchows Archiv 5/2014 Zur Ausgabe

Neu im Fachgebiet Pathologie