nach oben

Erschienen in:

10.02.2017 | Original Article

Factors that may influence polymorphous low-grade adenocarcinoma growth

verfasst von: Andresa Borges Soares, Elizabeth Ferreira Martinez, Patricia Fernandes Avila Ribeiro, Icleia Siqueira Barreto, Maria Cássia Aguiar, Cristiane Furuse, Marcelo Sperandio, Victor Angelo Montalli, Ney Soares de Araújo, Vera Cavalcanti de Araújo

Erschienen in: Virchows Archiv | Ausgabe 4/2017

Einloggen, um Zugang zu erhalten

Abstract

There is mounting evidence on the importance of some biological processes in tumor growth, such as vascular supply, apoptosis, autophagy, and senescence. We have investigated these processes in polymorphous low-grade adenocarcinoma (PLGA), in an attempt to identify those that are relevant for this particular lesion. We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. Our results showed that PLGA growth does not depend on newly formed vessels but only on preexisting vasculature. Furthermore, PLGA is promoted by autophagy, sustained by both anti-apoptotic and anti-senescence signals, and stimulated by Bcl-2 and survivin.

Luna MA, Wenig BM (2005) Polymorphous low-grade adenocarcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D, Ed. Pathol. Genet. Head Neck Tumours. pp 223–224

Freedman PD, Lumerman H (1983) Lobular carcinoma of intraoral minor salivary gland origin. Oral Surgery, Oral Med Oral Pathol 56:157–165. doi:10.1016/0030-4220(83)90282-7 CrossRef

Batsakis JG, Pinkston GR, Luna MA et al (1983) Adenocarcinomas of the oral cavity: a clinicopathologic study of terminal duct carcinomas. J Laryngol Otol 97:825–835. doi:10.1017/S0022215100095062 CrossRefPubMed

El-Naaj IA, Leiser Y, Wolff A, Peled M (2011) Polymorphous low grade adenocarcinoma: case series and review of surgical management. J Oral Maxillofac Surg 69:1967–1972. doi:10.1016/j.joms.2010.10.010 CrossRefPubMed

Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249–257. doi:10.1038/35025220 CrossRefPubMed

Detmar M, Hirakawa S (2002) The formation of lymphatic vessels and its importance in the setting of malignancy. J Exp Med 196:713–718CrossRefPubMedPubMedCentral

Ouyang L, Shi Z, Zhao S et al (2012) Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 45:487–498. doi:10.1111/j.1365-2184.2012.00845.x CrossRefPubMed

Townson JL, Naumov GN, Chambers AF (2003) The role of apoptosis in tumor progression and metastasis. Curr Mol Med 3:631–642CrossRefPubMed

Roberg K, Jonsson A-C, Grénman R, Norberg-Spaak L (2007) Radiotherapy response in oral squamous carcinoma cell lines: evaluation of apoptotic proteins as prognostic factors. Head Neck 29:325–334. doi:10.1002/hed CrossRefPubMed

10.

Levine B (2007) Cell biology: autophagy and cancer. Nature 446:745–747. doi:10.1038/446745a CrossRefPubMed

11.

Lindqvist LM, Simon a K, Baehrecke EH (2015) Current questions and possible controversies in autophagy. Cell Death Discov 1:15036. doi:10.1038/cddiscovery.2015.36 CrossRefPubMedPubMedCentral

12.

Cosway B, Lovat P (2016) The role of autophagy in squamous cell carcinoma of the head and neck. Oral Oncol 54:1–6. doi:10.1016/j.oraloncology.2015.12.007 CrossRefPubMed

13.

Burada F, Nicoli ER, Ciurea ME et al (2015) Autophagy in colorectal cancer: an important switch from physiology to pathology. World J Gastrointest Oncol 7:271–284. doi:10.4251/wjgo.v7.i11.271 CrossRefPubMedPubMedCentral

14.

Parkhitko AA, Favorova OO, Henske EP (2013) Autophagy: mechanisms, regulation, and its role in tumorigenesis. Biochemistry 78:355–367. doi:10.1134/S0006297913040044 PubMed

15.

Campisi J, d’Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729–740. doi:10.1038/nrm2233 CrossRefPubMed

16.

Collado M, Serrano M (2010) Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 10:51–57. doi:10.1038/nrc2772 CrossRefPubMedPubMedCentral

17.

Kuilman T, Michaloglou C, Mooi WJ, Peeper DS (2010) The essence of senescence. Genes Dev 24:2463–2479. doi:10.1101/gad.1971610 CrossRefPubMedPubMedCentral

18.

Michal M, Skálová A, Simpson RHW et al (1999) Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. Histopathology 35:495–501. doi:10.1046/j.1365-2559.1999.00792.x CrossRefPubMed

19.

Skalova A, Sima R, Kaspirkova-Nemcova J et al (2011) Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol 35:1168–1176. doi:10.1097/PAS.0b013e31821e1f54 CrossRefPubMed

20.

Weinreb I, Zhang L, Tirunagari LMS et al (2014) Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin. Genes Chromosom Cancer 53:845–856. doi:10.1002/gcc.22195 CrossRefPubMed

21.

Carmeliet P, Jain RK (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298–307. doi:10.1038/nature10144 CrossRefPubMedPubMedCentral

22.

Wong RSY (2011) Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res 30:87. doi:10.1186/1756-9966-30-87 CrossRefPubMedPubMedCentral

23.

Um H-D (2016) Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species. Oncotarget 7:5193–5203. doi:10.18632/oncotarget.6405 PubMed

24.

Hirano H, Yamaguchi T, Yokota S et al (2015) Survivin expression in lung cancer: association with smoking, histological types and pathological stages. Oncol Lett 10:1456–1462PubMedPubMedCentral

25.

Ko YH, Roh SY, Won HS et al (2010) Survivin expression in resected adenoid cystic carcinoma of the head and neck. Head Neck Oncol 30:30CrossRef

26.

Ettl T, Stiegler C, Zeitler K et al (2012) EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis. Hum Pathol 43:921–931. doi:10.1016/j.humpath.2011.08.006 CrossRefPubMed

27.

Kondo Y, Kanzawa T, Sawaya R, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5:726–734. doi:10.1038/nrc1692 CrossRefPubMed

28.

El-Khattouti A, Selimovic D, Haikel Y, Hassan M (2013) Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer. J Cell Death 6:37–55. doi:10.4137/JCD.S11034 PubMedPubMedCentral

29.

Beauséjour CM, Krtolica A, Galimi F et al (2003) Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 22:4212–4222. doi:10.1093/emboj/cdg417 CrossRefPubMedPubMedCentral

30.

Dimri GP (2005) What has senescence got to do with cancer? Cancer Cell 7:505–512. doi:10.1016/j.ccr.2005.05.025 CrossRefPubMedPubMedCentral

Titel: Factors that may influence polymorphous low-grade adenocarcinoma growth
verfasst von: Andresa Borges Soares
Elizabeth Ferreira Martinez
Patricia Fernandes Avila Ribeiro
Icleia Siqueira Barreto
Maria Cássia Aguiar
Cristiane Furuse
Marcelo Sperandio
Victor Angelo Montalli
Ney Soares de Araújo
Vera Cavalcanti de Araújo
Publikationsdatum: 10.02.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 4/2017
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-017-2085-3

Neu im Fachgebiet Pathologie

01.04.2024 | Forensische Traumatologie | CME

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Factors that may influence polymorphous low-grade adenocarcinoma growth

Abstract

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2017

Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas

Response to letter to the editor by Dr. Villanacci: toward optimal processing of endoscopic submucosal dissection specimens

Undifferentiated “round” cell (“Ewing-like”) sarcoma: not always so-round nor Ewing-like

The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis

Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue

Sharing of a PTPN11 mutation by myelodysplastic bone marrow and a mature plasmacytoid dendritic cell proliferation provides evidence for their common myelomonocytic origin

Neu im Fachgebiet Pathologie

Theoretische Grundlagen von Explosionen und Explosionsverletzungen

Auswirkungen vorgeschalteter Laborprozesse auf die Digitalisierung histologischer Schnittpräparate

Knochenmarkhistologie bei Zytopenien

Herausforderungen der Automation bei der quantitativen Auswertung von Leberbiopsien