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Brain Structure and Function

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01.05.2010 | Original article

Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography

verfasst von: Khader M. Hasan, Arash Kamali, Humaira Abid, Larry A. Kramer, Jack M. Fletcher, Linda Ewing-Cobbs

Erschienen in: Brain Structure and Function | Ausgabe 4/2010

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Abstract

Using diffusion tensor tractography, we quantified the microstructural changes in the association, projection, and commissural compact white matter pathways of the human brain over the lifespan in a cohort of healthy right-handed children and adults aged 6–68 years. In both males and females, the diffusion tensor radial diffusivity of the bilateral arcuate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, corticospinal, somatosensory tracts, and the corpus callosum followed a U-curve with advancing age; fractional anisotropy in the same pathways followed an inverted U-curve. Our study provides useful baseline data for the interpretation of data collected from patients.

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Titel: Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography
verfasst von: Khader M. Hasan
Arash Kamali
Humaira Abid
Larry A. Kramer
Jack M. Fletcher
Linda Ewing-Cobbs
Publikationsdatum: 01.05.2010
Verlag: Springer-Verlag
Erschienen in: Brain Structure and Function / Ausgabe 4/2010
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-009-0238-0

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Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography

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