Skip to main content
Erschienen in: Brain Structure and Function 4/2015

01.07.2015 | Original Article

The left inferior fronto-occipital fasciculus subserves language semantics: a multilevel lesion study

verfasst von: Fabien Almairac, Guillaume Herbet, Sylvie Moritz-Gasser, Nicolas Menjot de Champfleur, Hugues Duffau

Erschienen in: Brain Structure and Function | Ausgabe 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Consequential works in cognitive neuroscience have led to the formulation of an interactive dual-stream model of language processing: the dorsal stream may process the phonological aspects of language, whereas the ventral stream may process the semantic aspects of language. While it is well-accepted that the dorsal route is subserved by the arcuate fasciculus, the structural connectivity of the semantic ventral stream is a matter of dispute. Here we designed a longitudinal study to gain new insights into this central but controversial question. Thirty-one patients harboring a left diffuse low-grade glioma—a rare neurological condition that infiltrates preferentially white matter associative pathways—were assessed with a prototypical task of language (i.e. verbal fluency) before and after surgery. All were operated under local anesthesia with a cortical and subcortical brain mapping—enabling to identify and preserve eloquent structures for language. We performed voxel-based lesion-symptom (VLSM) analyses on pre- and postoperative behavioral data. Preoperatively, we found a significant relationship between semantic fluency scores and the white matter fibers shaping the ventro-lateral connectivity (P < 0.05 corrected). The statistical map was found to substantially overlap with the spatial position of the inferior fronto-occipital fasciculus (IFOF) (37.7 %). Furthermore, a negative correlation was observed between semantic fluency scores and the infiltration volumes in this fasciculus (r = −0.4, P = 0.029). Postoperatively, VLSM analyses were inconclusive. Taken as a whole and when combined with the literature data, our findings strengthen the view that the IFOF plays an essential role in semantic processing and may subserve the direct ventral pathway of language.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB (2011) Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain 134:2025–2035CrossRefPubMed Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB (2011) Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story. Brain 134:2025–2035CrossRefPubMed
Zurück zum Zitat Andersen SM, Rapcsak SZ, Beeson PM (2010) Cost function masking during normalization of brains with focal lesions: still a necessity? Neuroimage 53:78–84PubMedCentralCrossRefPubMed Andersen SM, Rapcsak SZ, Beeson PM (2010) Cost function masking during normalization of brains with focal lesions: still a necessity? Neuroimage 53:78–84PubMedCentralCrossRefPubMed
Zurück zum Zitat Baldo JV, Shimamura AP (1998) Letter and category fluency in patients with frontal lobe lesions. Neuropsychology 12:259–267CrossRefPubMed Baldo JV, Shimamura AP (1998) Letter and category fluency in patients with frontal lobe lesions. Neuropsychology 12:259–267CrossRefPubMed
Zurück zum Zitat Baldo JV, Schwartz S, Wilkins D, Dronkers NF (2006) Role of frontal versus temporal cortex in verbal fluency as revealed by voxel-based lesion symptom mapping. J Int Neuropsychol Soc 12:896–900CrossRefPubMed Baldo JV, Schwartz S, Wilkins D, Dronkers NF (2006) Role of frontal versus temporal cortex in verbal fluency as revealed by voxel-based lesion symptom mapping. J Int Neuropsychol Soc 12:896–900CrossRefPubMed
Zurück zum Zitat Bates E, Wilson SM, Saygin AP, Dick F, Sereno MI, Knight RT (2003) Voxel-based lesion-symptom mapping. Nat Neurosci 6:448–450PubMed Bates E, Wilson SM, Saygin AP, Dick F, Sereno MI, Knight RT (2003) Voxel-based lesion-symptom mapping. Nat Neurosci 6:448–450PubMed
Zurück zum Zitat Bi Y, Wei T, Wu C, Han Z, Jiang T, Caramazza A (2011) The role of the left anterior temporal lobe in language processing revisited: evidence from an individual with ATL resection. Cortex 47:575–587CrossRefPubMed Bi Y, Wei T, Wu C, Han Z, Jiang T, Caramazza A (2011) The role of the left anterior temporal lobe in language processing revisited: evidence from an individual with ATL resection. Cortex 47:575–587CrossRefPubMed
Zurück zum Zitat Binney RJ, Parker GJ, Lambon Ralph MA (2012) Convergent connectivity and graded specialization in the rostral human temporal lobe as revealed by diffusion-weighted imaging probabilistic tractography. J Cogn Neurosci 24:1998–2014CrossRefPubMed Binney RJ, Parker GJ, Lambon Ralph MA (2012) Convergent connectivity and graded specialization in the rostral human temporal lobe as revealed by diffusion-weighted imaging probabilistic tractography. J Cogn Neurosci 24:1998–2014CrossRefPubMed
Zurück zum Zitat Bonnetblanc F, Desmurget M, Duffau H (2006) Low grade gliomas and cerebral plasticity: fundamental and clinical implications. Med Sci (Paris) 22:389–394CrossRef Bonnetblanc F, Desmurget M, Duffau H (2006) Low grade gliomas and cerebral plasticity: fundamental and clinical implications. Med Sci (Paris) 22:389–394CrossRef
Zurück zum Zitat Brett M, Leff AP, Rorden C, Ashburner J (2001) Spatial normalization of brain images with focal lesions using cost function masking. Neuroimage 14:486–500CrossRefPubMed Brett M, Leff AP, Rorden C, Ashburner J (2001) Spatial normalization of brain images with focal lesions using cost function masking. Neuroimage 14:486–500CrossRefPubMed
Zurück zum Zitat Cardebat D, Doyon B, Puel M, Goulet P, Joanette Y (1990) Formal and semantic lexical evocation in normal subjects. Performance and dynamics of production as a function of sex, age and educational level. Acta Neurol Belg 90:207–217PubMed Cardebat D, Doyon B, Puel M, Goulet P, Joanette Y (1990) Formal and semantic lexical evocation in normal subjects. Performance and dynamics of production as a function of sex, age and educational level. Acta Neurol Belg 90:207–217PubMed
Zurück zum Zitat Catani M, Thiebaut de Schotten M (2008) A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 44:1105–1132CrossRefPubMed Catani M, Thiebaut de Schotten M (2008) A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 44:1105–1132CrossRefPubMed
Zurück zum Zitat Catani M, Howard RJ, Pajevic S, Jones DK (2002) Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 17:77–94CrossRefPubMed Catani M, Howard RJ, Pajevic S, Jones DK (2002) Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 17:77–94CrossRefPubMed
Zurück zum Zitat Catani M, Jones DK, ffytche DH (2005) Perisylvian language networks of the human brain. Ann Neurol 57:8–16CrossRefPubMed Catani M, Jones DK, ffytche DH (2005) Perisylvian language networks of the human brain. Ann Neurol 57:8–16CrossRefPubMed
Zurück zum Zitat De Witt Hamer PC, Robles SG, Zwinderman AH, Duffau H, Berger MS (2012) Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol 30:2559–2565CrossRefPubMed De Witt Hamer PC, Robles SG, Zwinderman AH, Duffau H, Berger MS (2012) Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol 30:2559–2565CrossRefPubMed
Zurück zum Zitat de Zubicaray GI, Rose SE, McMahon KL (2011) The structure and connectivity of semantic memory in the healthy older adult brain. Neuroimage 54:1488–1494CrossRefPubMed de Zubicaray GI, Rose SE, McMahon KL (2011) The structure and connectivity of semantic memory in the healthy older adult brain. Neuroimage 54:1488–1494CrossRefPubMed
Zurück zum Zitat Desmurget M, Bonnetblanc F, Duffau H (2007) Contrasting acute and slow-growing lesions: a new door to brain plasticity. Brain 130:898–914CrossRefPubMed Desmurget M, Bonnetblanc F, Duffau H (2007) Contrasting acute and slow-growing lesions: a new door to brain plasticity. Brain 130:898–914CrossRefPubMed
Zurück zum Zitat Duffau H (2005) Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol 4:476–486CrossRefPubMed Duffau H (2005) Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol 4:476–486CrossRefPubMed
Zurück zum Zitat Duffau H (2008) The anatomo-functional connectivity of language revisited. New insights provided by electrostimulation and tractography. Neuropsychologia 46:927–934CrossRefPubMed Duffau H (2008) The anatomo-functional connectivity of language revisited. New insights provided by electrostimulation and tractography. Neuropsychologia 46:927–934CrossRefPubMed
Zurück zum Zitat Duffau H (2013) The huge plastic potential of adult brain and the role of connectomics: New insights provided by serial mappings in glioma surgery. Cortex (in press) Duffau H (2013) The huge plastic potential of adult brain and the role of connectomics: New insights provided by serial mappings in glioma surgery. Cortex (in press)
Zurück zum Zitat Duffau H, Capelle L (2004) Preferential brain locations of low-grade gliomas. Cancer 100:2622–2626CrossRefPubMed Duffau H, Capelle L (2004) Preferential brain locations of low-grade gliomas. Cancer 100:2622–2626CrossRefPubMed
Zurück zum Zitat Duffau H, Capelle L, Sichez N, Denvil D, Lopes M, Sichez JP (2002) Intraoperative mapping of the subcortical language pathways using direct stimulations. An anatomo-functional study. Brain 125:199–214CrossRefPubMed Duffau H, Capelle L, Sichez N, Denvil D, Lopes M, Sichez JP (2002) Intraoperative mapping of the subcortical language pathways using direct stimulations. An anatomo-functional study. Brain 125:199–214CrossRefPubMed
Zurück zum Zitat Duffau H, Gatignol P, Mandonnet E, Peruzzi P, Tzourio-Mazoyer N, Capelle L (2005) New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations. Brain 128:797–810CrossRefPubMed Duffau H, Gatignol P, Mandonnet E, Peruzzi P, Tzourio-Mazoyer N, Capelle L (2005) New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations. Brain 128:797–810CrossRefPubMed
Zurück zum Zitat Duffau H, Peggy Gatignol ST, Mandonnet E, Capelle L, Taillandier L (2008) Intraoperative subcortical stimulation mapping of language pathways in a consecutive series of 115 patients with Grade II glioma in the left dominant hemisphere. J Neurosurg 109:461–471CrossRefPubMed Duffau H, Peggy Gatignol ST, Mandonnet E, Capelle L, Taillandier L (2008) Intraoperative subcortical stimulation mapping of language pathways in a consecutive series of 115 patients with Grade II glioma in the left dominant hemisphere. J Neurosurg 109:461–471CrossRefPubMed
Zurück zum Zitat Duffau H, Herbet G, Moritz-Gasser S (2013a) Toward a pluri-component, multimodal, and dynamic organization of the ventral semantic stream in humans: lessons from stimulation mapping in awake patients. Front Syst Neurosci 7:44PubMedCentralCrossRefPubMed Duffau H, Herbet G, Moritz-Gasser S (2013a) Toward a pluri-component, multimodal, and dynamic organization of the ventral semantic stream in humans: lessons from stimulation mapping in awake patients. Front Syst Neurosci 7:44PubMedCentralCrossRefPubMed
Zurück zum Zitat Duffau H, Moritz-Gasser S, Mandonnet E (2013b) A re-examination of neural basis of language processing: proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming. Brain Lang (in press) Duffau H, Moritz-Gasser S, Mandonnet E (2013b) A re-examination of neural basis of language processing: proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming. Brain Lang (in press)
Zurück zum Zitat Fernandez-Miranda JC, Rhoton AL Jr, Alvarez-Linera J, Kakizawa Y, Choi C, de Oliveira EP (2008) Three-dimensional microsurgical and tractographic anatomy of the white matter of the human brain. Neurosurgery 62:989–1026 (discussion 1026–1028)CrossRefPubMed Fernandez-Miranda JC, Rhoton AL Jr, Alvarez-Linera J, Kakizawa Y, Choi C, de Oliveira EP (2008) Three-dimensional microsurgical and tractographic anatomy of the white matter of the human brain. Neurosurgery 62:989–1026 (discussion 1026–1028)CrossRefPubMed
Zurück zum Zitat Gourovitch ML, Kirkby BS, Goldberg TE, Weinberger DR, Gold JM, Esposito G (2000) A comparison of rCBF patterns during letter and semantic fluency. Neuropsychology 14:353–360CrossRefPubMed Gourovitch ML, Kirkby BS, Goldberg TE, Weinberger DR, Gold JM, Esposito G (2000) A comparison of rCBF patterns during letter and semantic fluency. Neuropsychology 14:353–360CrossRefPubMed
Zurück zum Zitat Han Z, Ma Y, Gong G, He Y, Caramazza A, Bi Y (2013) White matter structural connectivity underlying semantic processing: evidence from brain damaged patients. Brain 136:2952–2965CrossRefPubMed Han Z, Ma Y, Gong G, He Y, Caramazza A, Bi Y (2013) White matter structural connectivity underlying semantic processing: evidence from brain damaged patients. Brain 136:2952–2965CrossRefPubMed
Zurück zum Zitat Henry JD, Crawford JR (2004) A meta-analytic review of verbal fluency performance following focal cortical lesions. Neuropsychology 18:284–295CrossRefPubMed Henry JD, Crawford JR (2004) A meta-analytic review of verbal fluency performance following focal cortical lesions. Neuropsychology 18:284–295CrossRefPubMed
Zurück zum Zitat Henry RG, Berman JI, Nagarajan SS, Mukherjee P, Berger MS (2004) Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping. Neuroimage 21:616–622PubMedCentralCrossRefPubMed Henry RG, Berman JI, Nagarajan SS, Mukherjee P, Berger MS (2004) Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping. Neuroimage 21:616–622PubMedCentralCrossRefPubMed
Zurück zum Zitat Herbet G, Lafargue G, Bonnetblanc F, Moritz-Gasser S, Duffau H (2013) Is the right frontal cortex really crucial in the mentalizing network? A longitudinal study in patients with a slow-growing lesion. Cortex 49:2711–2727CrossRefPubMed Herbet G, Lafargue G, Bonnetblanc F, Moritz-Gasser S, Duffau H (2013) Is the right frontal cortex really crucial in the mentalizing network? A longitudinal study in patients with a slow-growing lesion. Cortex 49:2711–2727CrossRefPubMed
Zurück zum Zitat Herbet G, Lafargue G, Bonnetblanc F, Moritz-Gasser S, Menjot de Champfleur N, Duffau H (2014) Inferring a dual-stream model of mentalizing from associative white matter fibres disconnection. Brain 137:944–959CrossRefPubMed Herbet G, Lafargue G, Bonnetblanc F, Moritz-Gasser S, Menjot de Champfleur N, Duffau H (2014) Inferring a dual-stream model of mentalizing from associative white matter fibres disconnection. Brain 137:944–959CrossRefPubMed
Zurück zum Zitat Hickok G, Poeppel D (2000) Towards a functional neuroanatomy of speech perception. Trends Cogn Sci 4:131–138CrossRefPubMed Hickok G, Poeppel D (2000) Towards a functional neuroanatomy of speech perception. Trends Cogn Sci 4:131–138CrossRefPubMed
Zurück zum Zitat Hickok G, Poeppel D (2004) Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language. Cognition 92:67–99CrossRefPubMed Hickok G, Poeppel D (2004) Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language. Cognition 92:67–99CrossRefPubMed
Zurück zum Zitat Hickok G, Poeppel D (2007) The cortical organization of speech processing. Nat Rev Neurosci 8:393–402CrossRefPubMed Hickok G, Poeppel D (2007) The cortical organization of speech processing. Nat Rev Neurosci 8:393–402CrossRefPubMed
Zurück zum Zitat Ius T, Angelini E, Thiebaut de Schotten M, Mandonnet E, Duffau H (2011) Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: towards a “minimal common brain”. Neuroimage 56:992–1000CrossRefPubMed Ius T, Angelini E, Thiebaut de Schotten M, Mandonnet E, Duffau H (2011) Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: towards a “minimal common brain”. Neuroimage 56:992–1000CrossRefPubMed
Zurück zum Zitat Jefferies E (2013) The neural basis of semantic cognition: converging evidence from neuropsychology, neuroimaging and TMS. Cortex 49:611–625CrossRefPubMed Jefferies E (2013) The neural basis of semantic cognition: converging evidence from neuropsychology, neuroimaging and TMS. Cortex 49:611–625CrossRefPubMed
Zurück zum Zitat Keidel JL, Welbourne SR, Lambon Ralph MA (2010) Solving the paradox of the equipotential and modular brain: a neurocomputational model of stroke vs. slow-growing glioma. Neuropsychologia 48:1716–1724CrossRefPubMed Keidel JL, Welbourne SR, Lambon Ralph MA (2010) Solving the paradox of the equipotential and modular brain: a neurocomputational model of stroke vs. slow-growing glioma. Neuropsychologia 48:1716–1724CrossRefPubMed
Zurück zum Zitat Klinger J (1935) Erleichterung der makroskopischen Praeparation des Gehirns durch den Gefrierprozess. Schweizer Archiv für Neurologie und Psychiatrie 36:247–256 Klinger J (1935) Erleichterung der makroskopischen Praeparation des Gehirns durch den Gefrierprozess. Schweizer Archiv für Neurologie und Psychiatrie 36:247–256
Zurück zum Zitat Krainik A, Duffau H, Capelle L, Cornu P, Boch AL, Mangin JF (2004) Role of the healthy hemisphere in recovery after resection of the supplementary motor area. Neurology 62:1323–1332CrossRefPubMed Krainik A, Duffau H, Capelle L, Cornu P, Boch AL, Mangin JF (2004) Role of the healthy hemisphere in recovery after resection of the supplementary motor area. Neurology 62:1323–1332CrossRefPubMed
Zurück zum Zitat Kummerer D, Hartwigsen G, Kellmeyer P, Glauche V, Mader I, Kloppel S (2013) Damage to ventral and dorsal language pathways in acute aphasia. Brain 136:619–629PubMedCentralCrossRefPubMed Kummerer D, Hartwigsen G, Kellmeyer P, Glauche V, Mader I, Kloppel S (2013) Damage to ventral and dorsal language pathways in acute aphasia. Brain 136:619–629PubMedCentralCrossRefPubMed
Zurück zum Zitat Lambon Ralph MA, Sage K, Jones RW, Mayberry EJ (2010) Coherent concepts are computed in the anterior temporal lobes. Proc Natl Acad Sci USA 107:2717–2722PubMedCentralCrossRefPubMed Lambon Ralph MA, Sage K, Jones RW, Mayberry EJ (2010) Coherent concepts are computed in the anterior temporal lobes. Proc Natl Acad Sci USA 107:2717–2722PubMedCentralCrossRefPubMed
Zurück zum Zitat Lichtheim L (1885) On aphasia. Brain 433–485 Lichtheim L (1885) On aphasia. Brain 433–485
Zurück zum Zitat Maldonado IL, Moritz-Gasser S, de Champfleur NM, Bertram L, Moulinie G, Duffau H (2011) Surgery for gliomas involving the left inferior parietal lobule: new insights into the functional anatomy provided by stimulation mapping in awake patients. J Neurosurg 115:770–779CrossRefPubMed Maldonado IL, Moritz-Gasser S, de Champfleur NM, Bertram L, Moulinie G, Duffau H (2011) Surgery for gliomas involving the left inferior parietal lobule: new insights into the functional anatomy provided by stimulation mapping in awake patients. J Neurosurg 115:770–779CrossRefPubMed
Zurück zum Zitat Maldonado IL, Mandonnet E, Duffau H (2012) Dorsal fronto-parietal connections of the human brain: a fiber dissection study of their composition and anatomical relationships. Anat Rec (Hoboken) 295:187–195CrossRef Maldonado IL, Mandonnet E, Duffau H (2012) Dorsal fronto-parietal connections of the human brain: a fiber dissection study of their composition and anatomical relationships. Anat Rec (Hoboken) 295:187–195CrossRef
Zurück zum Zitat Martino J, Brogna C, Robles SG, Vergani F, Duffau H (2010) Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data. Cortex 46:691–699CrossRefPubMed Martino J, Brogna C, Robles SG, Vergani F, Duffau H (2010) Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data. Cortex 46:691–699CrossRefPubMed
Zurück zum Zitat Menjot de Champfleur N, Lima Maldonado I, Moritz-Gasser S, Machi P, Le Bars E, Bonafe A (2013) Middle longitudinal fasciculus delineation within language pathways: a diffusion tensor imaging study in human. Eur J Radiol 82:151–157CrossRefPubMed Menjot de Champfleur N, Lima Maldonado I, Moritz-Gasser S, Machi P, Le Bars E, Bonafe A (2013) Middle longitudinal fasciculus delineation within language pathways: a diffusion tensor imaging study in human. Eur J Radiol 82:151–157CrossRefPubMed
Zurück zum Zitat Metz-Lutz MN, Kremin H, Deloche G (1991) Standardisation d’un test de dénomination orale : contrôle des effets de l’âge, du sexe et du niveau de scolarité chez les sujets adultes normaux. Rev Neuropsychol 1:73–95 Metz-Lutz MN, Kremin H, Deloche G (1991) Standardisation d’un test de dénomination orale : contrôle des effets de l’âge, du sexe et du niveau de scolarité chez les sujets adultes normaux. Rev Neuropsychol 1:73–95
Zurück zum Zitat Moritz-Gasser S, Herbet G, Duffau H (2013) Mapping the connectivity underlying multimodal (verbal and non-verbal) semantic processing: a brain electrostimulation study. Neuropsychologia 51:1814–1822CrossRefPubMed Moritz-Gasser S, Herbet G, Duffau H (2013) Mapping the connectivity underlying multimodal (verbal and non-verbal) semantic processing: a brain electrostimulation study. Neuropsychologia 51:1814–1822CrossRefPubMed
Zurück zum Zitat Mummery CJ, Patterson K, Hodges JR, Wise RJ (1996) Generating ‘tiger’ as an animal name or a word beginning with T: differences in brain activation. Proc Biol Sci 263:989–995CrossRefPubMed Mummery CJ, Patterson K, Hodges JR, Wise RJ (1996) Generating ‘tiger’ as an animal name or a word beginning with T: differences in brain activation. Proc Biol Sci 263:989–995CrossRefPubMed
Zurück zum Zitat Noonan KA, Jefferies E, Visser M, Lambon Ralph MA (2013) Going beyond inferior prefrontal involvement in semantic control: evidence for the additional contribution of dorsal angular gyrus and posterior middle temporal cortex. J Cogn Neurosci 25:1824–1850CrossRefPubMed Noonan KA, Jefferies E, Visser M, Lambon Ralph MA (2013) Going beyond inferior prefrontal involvement in semantic control: evidence for the additional contribution of dorsal angular gyrus and posterior middle temporal cortex. J Cogn Neurosci 25:1824–1850CrossRefPubMed
Zurück zum Zitat Parisot S, Duffau H, Chemouny S, Paragios N (2012) Joint tumor segmentation and dense deformable registration of brain MR images. Med Image Comput Comput Assist Interv 15:651–658PubMed Parisot S, Duffau H, Chemouny S, Paragios N (2012) Joint tumor segmentation and dense deformable registration of brain MR images. Med Image Comput Comput Assist Interv 15:651–658PubMed
Zurück zum Zitat Parker GJ, Luzzi S, Alexander DC, Wheeler-Kingshott CA, Ciccarelli O, Lambon Ralph MA (2005) Lateralization of ventral and dorsal auditory-language pathways in the human brain. Neuroimage 24:656–666CrossRefPubMed Parker GJ, Luzzi S, Alexander DC, Wheeler-Kingshott CA, Ciccarelli O, Lambon Ralph MA (2005) Lateralization of ventral and dorsal auditory-language pathways in the human brain. Neuroimage 24:656–666CrossRefPubMed
Zurück zum Zitat Rauschecker JP, Scott SK (2009) Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing. Nat Neurosci 12:718–724PubMedCentralCrossRefPubMed Rauschecker JP, Scott SK (2009) Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing. Nat Neurosci 12:718–724PubMedCentralCrossRefPubMed
Zurück zum Zitat Rorden C, Karnath HO, Bonilha L (2007) Improving lesion-symptom mapping. J Cogn Neurosci 19:1081–1088CrossRefPubMed Rorden C, Karnath HO, Bonilha L (2007) Improving lesion-symptom mapping. J Cogn Neurosci 19:1081–1088CrossRefPubMed
Zurück zum Zitat Sarubbo S, De Benedictis A, Maldonado IL, Basso G, Duffau H (2013) Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle. Brain Struct Funct 218:21–37CrossRefPubMed Sarubbo S, De Benedictis A, Maldonado IL, Basso G, Duffau H (2013) Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle. Brain Struct Funct 218:21–37CrossRefPubMed
Zurück zum Zitat Saur D, Kreher BW, Schnell S, Kummerer D, Kellmeyer P, Vry MS (2008) Ventral and dorsal pathways for language. Proc Natl Acad Sci USA 105:18035–18040PubMedCentralCrossRefPubMed Saur D, Kreher BW, Schnell S, Kummerer D, Kellmeyer P, Vry MS (2008) Ventral and dorsal pathways for language. Proc Natl Acad Sci USA 105:18035–18040PubMedCentralCrossRefPubMed
Zurück zum Zitat Schapiro AC, McClelland JL, Welbourne SR, Rogers TT, Lambon Ralph MA (2013) Why bilateral damage is worse than unilateral damage to the brain. J Cogn Neurosci Schapiro AC, McClelland JL, Welbourne SR, Rogers TT, Lambon Ralph MA (2013) Why bilateral damage is worse than unilateral damage to the brain. J Cogn Neurosci
Zurück zum Zitat Schwartz S, Baldo J, Graves RE, Brugger P (2003) Pervasive influence of semantics in letter and category fluency: a multidimensional approach. Brain Lang 87:400–411CrossRefPubMed Schwartz S, Baldo J, Graves RE, Brugger P (2003) Pervasive influence of semantics in letter and category fluency: a multidimensional approach. Brain Lang 87:400–411CrossRefPubMed
Zurück zum Zitat Schwartz MF, Kimberg DY, Walker GM, Brecher A, Faseyitan OK, Dell GS (2011) Neuroanatomical dissociation for taxonomic and thematic knowledge in the human brain. Proc Natl Acad Sci USA 108:8520–8524PubMedCentralCrossRefPubMed Schwartz MF, Kimberg DY, Walker GM, Brecher A, Faseyitan OK, Dell GS (2011) Neuroanatomical dissociation for taxonomic and thematic knowledge in the human brain. Proc Natl Acad Sci USA 108:8520–8524PubMedCentralCrossRefPubMed
Zurück zum Zitat Schwartz MF, Faseyitan O, Kim J, Coslett HB (2012) The dorsal stream contribution to phonological retrieval in object naming. Brain 135:3799–3814PubMedCentralCrossRefPubMed Schwartz MF, Faseyitan O, Kim J, Coslett HB (2012) The dorsal stream contribution to phonological retrieval in object naming. Brain 135:3799–3814PubMedCentralCrossRefPubMed
Zurück zum Zitat Schwindt GC, Graham NL, Rochon E, Tang-Wai DF, Lobaugh NJ, Chow TW (2013) Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia. Hum Brain Mapp 34:973–984CrossRefPubMed Schwindt GC, Graham NL, Rochon E, Tang-Wai DF, Lobaugh NJ, Chow TW (2013) Whole-brain white matter disruption in semantic and nonfluent variants of primary progressive aphasia. Hum Brain Mapp 34:973–984CrossRefPubMed
Zurück zum Zitat Szelenyi A, Bello L, Duffau H, Fava E, Feigl GC, Galanda M (2010) Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice. Neurosurg Focus 28:E7CrossRefPubMed Szelenyi A, Bello L, Duffau H, Fava E, Feigl GC, Galanda M (2010) Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice. Neurosurg Focus 28:E7CrossRefPubMed
Zurück zum Zitat Teixidor P, Gatignol P, Leroy M, Masuet-Aumatell C, Capelle L, Duffau H (2007) Assessment of verbal working memory before and after surgery for low-grade glioma. J Neurooncol 81:305–313CrossRefPubMed Teixidor P, Gatignol P, Leroy M, Masuet-Aumatell C, Capelle L, Duffau H (2007) Assessment of verbal working memory before and after surgery for low-grade glioma. J Neurooncol 81:305–313CrossRefPubMed
Zurück zum Zitat Thiebaut de Schotten M, Ffytche DH, Bizzi A, Dell’Acqua F, Allin M, Walshe M (2011) Atlasing location, asymmetry and inter-subject variability of white matter tracts in the human brain with MR diffusion tractography. Neuroimage 54:49–59CrossRefPubMed Thiebaut de Schotten M, Ffytche DH, Bizzi A, Dell’Acqua F, Allin M, Walshe M (2011) Atlasing location, asymmetry and inter-subject variability of white matter tracts in the human brain with MR diffusion tractography. Neuroimage 54:49–59CrossRefPubMed
Zurück zum Zitat Ture U, Yasargil MG, Friedman AH, Al-Mefty O (2000) Fiber dissection technique: lateral aspect of the brain. Neurosurgery 47:417–426 (discussion 426–417)CrossRefPubMed Ture U, Yasargil MG, Friedman AH, Al-Mefty O (2000) Fiber dissection technique: lateral aspect of the brain. Neurosurgery 47:417–426 (discussion 426–417)CrossRefPubMed
Zurück zum Zitat Ueno T, Lambon Ralph MA (2013) The roles of the “ventral” semantic and “dorsal” pathways in conduite d’approche: a neuroanatomically-constrained computational modeling investigation. Front Hum Neurosci 7:422PubMedCentralCrossRefPubMed Ueno T, Lambon Ralph MA (2013) The roles of the “ventral” semantic and “dorsal” pathways in conduite d’approche: a neuroanatomically-constrained computational modeling investigation. Front Hum Neurosci 7:422PubMedCentralCrossRefPubMed
Zurück zum Zitat Ueno T, Saito S, Rogers TT, Lambon Ralph MA (2011) Lichtheim 2: synthesizing aphasia and the neural basis of language in a neurocomputational model of the dual dorsal-ventral language pathways. Neuron 72:385–396CrossRefPubMed Ueno T, Saito S, Rogers TT, Lambon Ralph MA (2011) Lichtheim 2: synthesizing aphasia and the neural basis of language in a neurocomputational model of the dual dorsal-ventral language pathways. Neuron 72:385–396CrossRefPubMed
Zurück zum Zitat van Geemen K, Herbet G, Moritz-Gasser S, Duffau H (2013) Limited plastic potential of the left ventral premotor cortex in speech articulation: evidence From intraoperative awake mapping in glioma patients. Hum Brain Mapp van Geemen K, Herbet G, Moritz-Gasser S, Duffau H (2013) Limited plastic potential of the left ventral premotor cortex in speech articulation: evidence From intraoperative awake mapping in glioma patients. Hum Brain Mapp
Zurück zum Zitat Vigneau M, Beaucousin V, Herve PY, Duffau H, Crivello F, Houde O (2006) Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing. Neuroimage 30:1414–1432CrossRefPubMed Vigneau M, Beaucousin V, Herve PY, Duffau H, Crivello F, Houde O (2006) Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing. Neuroimage 30:1414–1432CrossRefPubMed
Zurück zum Zitat Visser M, Jefferies E, Lambon Ralph MA (2010) Semantic processing in the anterior temporal lobes: a meta-analysis of the functional neuroimaging literature. J Cogn Neurosci 22:1083–1094CrossRefPubMed Visser M, Jefferies E, Lambon Ralph MA (2010) Semantic processing in the anterior temporal lobes: a meta-analysis of the functional neuroimaging literature. J Cogn Neurosci 22:1083–1094CrossRefPubMed
Zurück zum Zitat Weiller C, Bormann T, Saur D, Musso M, Rijntjes M (2011) How the ventral pathway got lost: and what its recovery might mean. Brain Lang 118:29–39CrossRefPubMed Weiller C, Bormann T, Saur D, Musso M, Rijntjes M (2011) How the ventral pathway got lost: and what its recovery might mean. Brain Lang 118:29–39CrossRefPubMed
Zurück zum Zitat Wernicke C (1874) The aphasic symptom-complex. A psychological study on an anatomical basis. Arch Neurol 22:280–282CrossRef Wernicke C (1874) The aphasic symptom-complex. A psychological study on an anatomical basis. Arch Neurol 22:280–282CrossRef
Zurück zum Zitat Whitney C, Kirk M, O’Sullivan J, Lambon Ralph MA, Jefferies E (2011) The neural organization of semantic control: TMS evidence for a distributed network in left inferior frontal and posterior middle temporal gyrus. Cereb Cortex 21:1066–1075PubMedCentralCrossRefPubMed Whitney C, Kirk M, O’Sullivan J, Lambon Ralph MA, Jefferies E (2011) The neural organization of semantic control: TMS evidence for a distributed network in left inferior frontal and posterior middle temporal gyrus. Cereb Cortex 21:1066–1075PubMedCentralCrossRefPubMed
Metadaten
Titel
The left inferior fronto-occipital fasciculus subserves language semantics: a multilevel lesion study
verfasst von
Fabien Almairac
Guillaume Herbet
Sylvie Moritz-Gasser
Nicolas Menjot de Champfleur
Hugues Duffau
Publikationsdatum
01.07.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 4/2015
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-014-0773-1

Weitere Artikel der Ausgabe 4/2015

Brain Structure and Function 4/2015 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.