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Medical Microbiology and Immunology

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01.06.2008 | Review

Dynamics of T cell memory in human cytomegalovirus infection

verfasst von: Edward C. P. Waller, Elizabeth Day, J. G. Patrick Sissons, Mark R. Wills

Erschienen in: Medical Microbiology and Immunology | Ausgabe 2/2008

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Abstract

Primary human cytomegalovirus (HCMV) infection of an immunocompetent individual leads to the generation of a robust CD4+ and CD8+ T cell response which subsequently controls viral replication. HCMV is never cleared from the host and enters into latency with periodic reactivation and viral replication, which is controlled by reactivation of the memory T cells. In this article, we discuss the magnitude, phenotype and clonality of the T cell response following primary HCMV infection, the selection of responding T cells into the long-term memory pool and maintenance of this memory T cell population in the face of a latent/persistent infection. The article also considers the effect that this long-term surveillance of HCMV has on the T cell memory phenotype, their differentiation, function and the associated concepts of T cell memory inflation and immunosenescence.

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Titel: Dynamics of T cell memory in human cytomegalovirus infection
verfasst von: Edward C. P. Waller
Elizabeth Day
J. G. Patrick Sissons
Mark R. Wills
Publikationsdatum: 01.06.2008
Verlag: Springer Berlin Heidelberg
Erschienen in: Medical Microbiology and Immunology / Ausgabe 2/2008
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-008-0082-5

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Dynamics of T cell memory in human cytomegalovirus infection

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