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Medical Microbiology and Immunology

Erschienen in:

01.02.2012 | Review

Recent publications in medical microbiology and immunology: a retrospective

verfasst von: H. W. Doerr, J. Cinatl

Erschienen in: Medical Microbiology and Immunology | Ausgabe 1/2012

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Abstract

A look back is done to some clinical and basic research activities recently published in medical microbiology and immunology. The review covers clinical experiences and in vitro experiments to understand the emergency, pathogenicity, epidemic spread, and vaccine-based prevention of avian and swine-origin flu. Some new developments and concepts in diagnosis, (molecular) epidemiology, and therapy of AIDS, viral hepatitis C, and herpesvirus-associated diseases are outlined. Regulation of immune system has been discussed in a special issue 2010 including some aspects of CNS affections (measles). Mycobacterial infection and its prevention by modern recombinant vaccines have reached new interest, as well as new concepts of vaccination and prophylaxis against several other bacteria. Adaptation to host niches enables immune escape (example brucella) and determines virulence (example N. meningitidis). Chlamydia pneumoniae, previously considered to trigger atherosclerosis, is hypothetically associated to Alzheimer disease, while CMV, another putative trigger of atherosclerosis, gains evidence of oncomodulation in CNS tumor diseases. In terms of globalization, exotic virus infections are increasingly imported from southern countries.

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Cinatl J Jr, Michaelis M, Doerr HW (2007) The threat of avian influenza A (H5N1). Part IV: development of vaccines. Med Microbiol Immunol 196:213–225PubMedCrossRef

Doerr HW, Varwig D, Allwinn R, Cinatl J (2006) Will the next human influenza pandemic be caused by the virus of the avian flu A/H5N1? Arguments pro and counter. Med Microbiol Immunol 195:45–47PubMedCrossRef

Michaelis M, Doerr HW, Cinatl J Jr (2009) Of chickens and men: avian influenza in humans. Curr Mol Med 9:131–151PubMedCrossRef

Rabenau HF, Richter M, Doerr HW (2010) Hand, foot and mouth disease: seroprevalence of Coxsackie A16 and enterovirus 71 in Germany. Med Microbiol Immunol 199:45–51PubMedCrossRef

Michaelis M, Doerr HW, Cinatl J Jr (2009) Novel swine-origin influenza A virus in humans: another pandemic knocking at the door. Med Microbiol Immunol 198:175–183PubMedCrossRef

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Michaelis M, Doerr HW, Cinatl J Jr (2011) Investigation of the influence of EPs(R) 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. Phytomedicine 18:384–386PubMedCrossRef

19.

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22.

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25.

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26.

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27.

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30.

Lubeck PR, Doerr HW, Rabenau HF (2010) Epidemiology of human cytomegalovirus (HCMV) in an urban region of Germany: what has changed? Med Microbiol Immunol 199:53–60PubMedCrossRef

31.

Michaelis M, Doerr HW, Cinatl J Jr (2009) Oncomodulation by human cytomegalovirus: evidence becomes stronger. Med Microbiol Immunol 198:79–81PubMedCrossRef

32.

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33.

Raggam RB, Bozic M, Salzer HJ, Hammerschmidt S, Homberg C et al (2010) Rapid quantitation of cytomegalovirus DNA in whole blood by a new molecular assay based on automated sample preparation and real-time PCR. Med Microbiol Immunol 199:311–316PubMedCrossRef

34.

Sun Z, Ceng X, Mao Z, Wang J, Liu Q et al (2009) Diagnostic value of HCMV pp65 antigen detection by FCA for symptomatic and asymptomatic infection: compared to quantification of HCMV DNA and detection of IgM antibody in infants. Med Microbiol Immunol 198:107–112PubMedCrossRef

35.

Kampmann SE, Schindele B, Apelt L, Buhrer C, Garten L et al (2011) Pyrosequencing allows the detection of emergent ganciclovir resistance mutations after HCMV infection. Med Microbiol Immunol 200:109–113PubMedCrossRef

36.

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37.

Bleymehl K, Cinatl J, Schmidt-Chanasit J (2011) Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet. Med Microbiol Immunol 200:193–202PubMedCrossRef

38.

Wu F, Xing J, Wang S, Li M, Zheng C (2011) Screening and identification of host factors interacting with UL14 of herpes simplex virus 1. Med Microbiol Immunol 200:203–208PubMedCrossRef

39.

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43.

Hunig T, Luhder F, Elflein K, Gogishvili T, Frohlich M et al (2010) CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation. Med Microbiol Immunol 199:239–246PubMedCrossRef

44.

Avota E, Gassert E, Schneider-Schaulies S (2010) Measles virus-induced immunosuppression: from effectors to mechanisms. Med Microbiol Immunol 199:227–237PubMedCrossRef

45.

Reuter D, Schneider-Schaulies J (2010) Measles virus infection of the CNS: human disease, animal models, and approaches to therapy. Med Microbiol Immunol 199:261–271PubMedCrossRef

46.

Dobrindt U, Chowdary MG, Krumbholz G, Hacker J (2010) Genome dynamics and its impact on evolution of Escherichia coli. Med Microbiol Immunol 199:145–154PubMedCrossRef

47.

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48.

Schielke S, Frosch M, Kurzai O (2010) Virulence determinants involved in differential host niche adaptation of Neisseria meningitidis and Neisseria gonorrhoeae. Med Microbiol Immunol 199:185–196PubMedCrossRef

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Lappann M, Vogel U (2010) Biofilm formation by the human pathogen Neisseria meningitidis. Med Microbiol Immunol 199:173–183PubMedCrossRef

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Morschhauser J (2010) Regulation of white-opaque switching in Candida albicans. Med Microbiol Immunol 199:165–172PubMedCrossRef

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Brehm K (2010) The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host-parasite interaction. Med Microbiol Immunol 199:247–259PubMedCrossRef

52.

Biru T, Lennemann T, Sturmer M, Stephan C, Nisius G et al (2010) Human immunodeficiency virus type-1 group M quasispecies evolution: diversity and divergence in patients co-infected with active tuberculosis. Med Microbiol Immunol 199:323–332PubMedCrossRef

53.

Higuchi K, Kawabe Y, Mitarai S, Yoshiyama T, Harada N et al (2009) Comparison of performance in two diagnostic methods for tuberculosis infection. Med Microbiol Immunol 198:33–37PubMedCrossRef

54.

Kumar M, Sundaramurthi JC, Mehra NK, Kaur G, Raja A (2010) Cellular immune response to Mycobacterium tuberculosis-specific antigen culture filtrate protein-10 in south India. Med Microbiol Immunol 199:11–25PubMedCrossRef

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Wang C, Chen Z, Fu R, Zhang Y, Chen L et al (2011) A DNA vaccine expressing CFP21 and MPT64 fusion protein enhances BCG-induced protective immunity against Mycobacterium tuberculosis infection in mice. Med Microbiol Immunol 200:165–175PubMedCrossRef

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Wang J, Qie Y, Zhu B, Zhang H, Xu Y et al (2009) Evaluation of a recombinant BCG expressing antigen Ag85B and PPE protein Rv3425 from DNA segment RD11 of Mycobacterium tuberculosis in C57BL/6 mice. Med Microbiol Immunol 198:5–11PubMedCrossRef

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Huygen K, Adjei O, Affolabi D, Bretzel G, Demangel C et al (2009) Buruli ulcer disease: prospects for a vaccine. Med Microbiol Immunol 198:69–77PubMedCrossRef

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Makidon PE, Knowlton J, Groom JV 2nd, Blanco LP, LiPuma JJ et al (2010) Induction of immune response to the 17 kDa OMPA Burkholderia cenocepacia polypeptide and protection against pulmonary infection in mice after nasal vaccination with an OMP nanoemulsion-based vaccine. Med Microbiol Immunol 199:81–92PubMedCrossRef

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Uppada JB, Khan AA, Bhat AA, Deshmukh R, Rao DN (2009) Humoral immune responses and protective efficacy of sequential B- and T-cell epitopes of V antigen of Yersinia pestis by intranasal immunization in microparticles. Med Microbiol Immunol 198:247–256PubMedCrossRef

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Errea A, Moreno G, Sisti F, Fernandez J, Rumbo M et al (2010) Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization. Med Microbiol Immunol 199:103–108PubMedCrossRef

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Roop RM II, Gaines JM, Anderson ES, Caswell CC, Martin DW (2009) Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host. Med Microbiol Immunol 198:221–238PubMedCrossRef

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Shima K, Kuhlenbaumer G, Rupp J (2010) Chlamydia pneumoniae infection and Alzheimer’s disease: a connection to remember? Med Microbiol Immunol 199:283–289PubMedCrossRef

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69.

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70.

Mertens M, Wolfel R, Ullrich K, Yoshimatsu K, Blumhardt J et al (2009) Seroepidemiological study in a Puumala virus outbreak area in South-East Germany. Med Microbiol Immunol 198:83–91PubMedCrossRef

71.

Tappe D, Schmidt-Chanasit J, Ries A, Ziegler U, Muller A et al (2009) Ross River virus infection in a traveller returning from northern Australia. Med Microbiol Immunol 198:271–273PubMedCrossRef

72.

Allwinn R (2011) Significant increase in travel-associated dengue fever in Germany. Med Microbiol Immunol 200:155–159

73.

Panning M, Wichmann D, Grywna K, Annan A, Wijesinghe S et al (2009) No evidence of chikungunya virus and antibodies shortly before the outbreak on Sri Lanka. Med Microbiol Immunol 198:103–106PubMedCrossRef

74.

Maurer M, Dondji B, von Stebut E (2009) What determines the success or failure of intracellular cutaneous parasites? Lessons learned from leishmaniasis. Med Microbiol Immunol 198:137–146PubMedCrossRef

Titel: Recent publications in medical microbiology and immunology: a retrospective
verfasst von: H. W. Doerr
J. Cinatl
Publikationsdatum: 01.02.2012
Verlag: Springer-Verlag
Erschienen in: Medical Microbiology and Immunology / Ausgabe 1/2012
Print ISSN: 0300-8584
Elektronische ISSN: 1432-1831
DOI: https://doi.org/10.1007/s00430-011-0219-9

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